Articles producció científica> Enginyeria Electrònica, Elèctrica i Automàtica

Divergent Effects of Glycemic Control and Bariatric Surgery on Circulating Concentrations of TMAO in Newly Diagnosed T2D Patients and Morbidly Obese

  • Identification data

    Identifier: imarina:9287705
  • Authors:

    Canyelles, Marina
    Perez, Antonio
    Junza, Alexandra
    Minambres, Inka
    Yanes, Oscar
    Sarda, Helena
    Rotllan, Noemi
    Julve, Josep
    Luis Sanchez-Quesada, Jose
    Tondo, Mireia
    Escola-Gil, Joan Carles
    Blanco-Vaca, Francisco
  • Others:

    Author, as appears in the article.: Canyelles, Marina; Perez, Antonio; Junza, Alexandra; Minambres, Inka; Yanes, Oscar; Sarda, Helena; Rotllan, Noemi; Julve, Josep; Luis Sanchez-Quesada, Jose; Tondo, Mireia; Escola-Gil, Joan Carles; Blanco-Vaca, Francisco;
    Department: Enginyeria Electrònica, Elèctrica i Automàtica
    URV's Author/s: Junza Martínez, Alexandra / Yanes Torrado, Óscar
    Keywords: Γ-butyrobetaine Type 2 diabetes Trimethylamine-n-oxide Trimethylamine n-oxide Risk Obesity Mortality Microbial-metabolism Liquid chromatography–mass spectrometry Liquid chromatography-mass spectrometry Glycemic control Gamma-butyrobetaine Choline Carnitine Butyrobetaine
    Abstract: High circulating concentrations of the gut microbiota-derived metabolite trimethylamine N-oxide (TMAO) are significantly associated with the risk of obesity and type 2 diabetes (T2D). We aimed at evaluating the impact of glycemic control and bariatric surgery on circulating concentrations of TMAO and its microbiota-dependent intermediate, gamma-butyrobetaine (gamma BB), in newly diagnosed T2D patients and morbidly obese subjects following a within-subject design. Based on HbA1c concentrations, T2D patients achieved glycemic control. However, the plasma TMAO and gamma BB concentrations were significantly increased, without changes in estimated glomerular filtration rate. Bariatric surgery was very effective in reducing weight in obese subjects. Nevertheless, the surgery reduced plasma gamma BB concentrations without affecting TMAO concentrations and the estimated glomerular filtration rate. Considering these results, an additional experiment was carried out in male C57BL/6J mice fed a Western-type diet for twelve weeks. Neither diet-induced obesity nor insulin resistance were associated with circulating TMAO and gamma BB concentrations in these genetically defined mice strains. Our findings do not support that glycemic control or bariatric surgery improve the circulating concentrations of TMAO in newly diagnosed T2D and morbidly obese patients.
    Thematic Areas: Medicine, general & internal Clinical biochemistry
    licence for use: https://creativecommons.org/licenses/by/3.0/es/
    Author's mail: oscar.yanes@urv.cat alexandra.junza@urv.cat
    Author identifier: 0000-0003-3695-7157 0000-0001-7205-0419
    Record's date: 2023-12-17
    Papper version: info:eu-repo/semantics/publishedVersion
    Link to the original source: https://www.mdpi.com/2075-4418/12/11/2783
    Licence document URL: http://repositori.urv.cat/ca/proteccio-de-dades/
    Papper original source: Diagnostics. 12 (11):
    APA: Canyelles, Marina; Perez, Antonio; Junza, Alexandra; Minambres, Inka; Yanes, Oscar; Sarda, Helena; Rotllan, Noemi; Julve, Josep; Luis Sanchez-Quesada, (2022). Divergent Effects of Glycemic Control and Bariatric Surgery on Circulating Concentrations of TMAO in Newly Diagnosed T2D Patients and Morbidly Obese. Diagnostics, 12(11), -. DOI: 10.3390/diagnostics12112783
    Article's DOI: 10.3390/diagnostics12112783
    Entity: Universitat Rovira i Virgili
    Journal publication year: 2022
    Publication Type: Journal Publications
  • Keywords:

    Clinical Biochemistry,Medicine, General & Internal
    Γ-butyrobetaine
    Type 2 diabetes
    Trimethylamine-n-oxide
    Trimethylamine n-oxide
    Risk
    Obesity
    Mortality
    Microbial-metabolism
    Liquid chromatography–mass spectrometry
    Liquid chromatography-mass spectrometry
    Glycemic control
    Gamma-butyrobetaine
    Choline
    Carnitine
    Butyrobetaine
    Medicine, general & internal
    Clinical biochemistry
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