Author, as appears in the article.: Just-Borràs L; Cilleros-Mañé V; Polishchuk A; Balanyà-Segura M; Tomàs M; Garcia N; Tomàs J; Lanuza MA
Department: Ciències Mèdiques Bàsiques
URV's Author/s: Balanya Segura, Marta / Cilleros Mañé, Víctor / Garcia Sancho, Maria de les Neus / Just Borràs, Laia / Lanuza Escolano, María Angel / POLISHCHUK, ALEKSANDRA / Tomás Ferré, José Maria / Tomas Marginet, Marta
Keywords: Trkb-bdnf Skeletal muscle Protein-kinase-c Pkc Pka Neuromuscular junction Fatigue-resistant Eom synaptosome-associated protein skeletal-muscle skeletal muscle pkc pka neurotrophic factor neurotransmitter release neuromuscular-transmission neuromuscular junction motor-neuron fiber-type fatigue-resistant eom differential phosphorylation dependent phosphorylation
Abstract: At the neuromuscular junction (NMJ), motor neurons and myocytes maintain a bidirectional communication that guarantees adequate functionality. Thus, motor neurons’ firing pattern, which is influenced by retrograde muscle-derived neurotrophic factors, modulates myocyte contractibility. Myocytes can be fast-twitch fibers and become easily fatigued or slow-twitch fibers and resistant to fatigue. Extraocular muscles (EOM) show mixed properties that guarantee fast contraction speed and resistance to fatigue and the degeneration caused by Amyotrophic lateral sclerosis (ALS) disease. The TrkB signaling is an activity-dependent pathway implicated in the NMJ well-functioning. Therefore, it could mediate the differences between fast and slow myocytes’ resistance to fatigue. The present study elucidates a specific protein expression profile concerning the TrkB signaling that correlates with higher resistance to fatigue and better neuroprotective capacity through time. The results unveil that Extra-ocular muscles (EOM) express lower levels of NT-4 that extend TrkB signaling, differential PKC expression, and a higher abundance of phosphorylated synaptic proteins that correlate with continuous neurotransmission requirements. Furthermore, common molecular features between EOM and slow soleus muscles including higher neurotrophic consumption and classic and novel PKC isoforms balance correlate with better preservation of these two muscles in ALS. Altogether, higher resistance of Soleus and EOM to fatigue and ALS seems to be associated with specific protein levels concerning the TrkB neurotrophic signaling.
Thematic Areas: Neurosciences Molecular biology Medicina ii Ciências biológicas ii Cellular and molecular neuroscience
licence for use: https://creativecommons.org/licenses/by/3.0/es/
Author's mail: laia.just@urv.cat marta.tomas@urv.cat marta.balanya@urv.cat aleksandra.polishchuk@urv.cat mariaangel.lanuza@urv.cat laia.just@urv.cat josepmaria.tomas@urv.cat victor.cilleros@urv.cat marta.balanya@urv.cat aleksandra.polishchuk@urv.cat
Author identifier: 0000-0003-0473-3730 0000-0002-4151-1697 0000-0003-0983-4944 0000-0001-6445-1538 0000-0003-4795-4103 0000-0003-0473-3730 0000-0002-0406-0006 0000-0001-5690-9932 0000-0003-0983-4944 0000-0001-6445-1538
Record's date: 2024-04-13
Papper version: info:eu-repo/semantics/publishedVersion
Link to the original source: https://www.frontiersin.org/articles/10.3389/fnmol.2022.1069940/full
Licence document URL: http://repositori.urv.cat/ca/proteccio-de-dades/
Papper original source: Frontiers In Molecular Neuroscience. 15 1069940-
APA: Just-Borràs L; Cilleros-Mañé V; Polishchuk A; Balanyà-Segura M; Tomàs M; Garcia N; Tomàs J; Lanuza MA (2022). TrkB signaling is correlated with muscular fatigue resistance and less vulnerability to neurodegeneration. Frontiers In Molecular Neuroscience, 15(), 1069940-. DOI: 10.3389/fnmol.2022.1069940
Article's DOI: 10.3389/fnmol.2022.1069940
Entity: Universitat Rovira i Virgili
Journal publication year: 2022
Publication Type: Journal Publications
Repositori URV