Articles producció científica> Medicina i Cirurgia

Women with familial hypercholesterolemia phenotype are undertreated and poorly controlled compared to men

  • Identification data

    Identifier: imarina:9290346
  • Authors:

    Zamora, A
    Ramos, R
    Comas-Cufi, M
    García-Gil, M
    Martí-Lluch, R
    Plana, N
    Alves-Cabratosa, L
    Ponjoan, A
    Rodríguez-Borjabad, C
    Ibarretxe, D
    Roman-Degano, I
    Marrugat, J
    Elosua, R
    Martín-Urda, A
    Masana, L
  • Others:

    Author, as appears in the article.: Zamora, A; Ramos, R; Comas-Cufi, M; García-Gil, M; Martí-Lluch, R; Plana, N; Alves-Cabratosa, L; Ponjoan, A; Rodríguez-Borjabad, C; Ibarretxe, D; Roman-Degano, I; Marrugat, J; Elosua, R; Martín-Urda, A; Masana, L
    Department: Medicina i Cirurgia
    URV's Author/s: Ibarretxe Gerediaga, Daiana / Masana Marín, Luis / Plana Gil, Núria / Rodríguez Borjabad, Cèlia
    Keywords: Coronary-heart-disease united-states therapy sex-differences primary-care prevalence participants gender disparities adherence
    Abstract: Familial hypercholesterolemia (FH) is an autosomal dominant disease that has a prevalence of approximately 1/250 inhabitants and is the most frequent cause of early coronary heart disease (CHD). We included 1.343.973 women and 1.210.671 men with at least one LDL-c measurement from the Catalan primary care database. We identified 14.699 subjects with Familial hypercholesterolemia-Phenotype (FH-P) based on LDL-c cut-off points by age (7.033 and 919 women, and 5.088 and 1659 men in primary and secondary prevention, respectively). Lipid lower therapy (LLT), medication possession ratio (MPR) as an indicator of adherence, and number of patients that reached their goal on lipid levels were compared by sex. In primary and secondary prevention, 69% and 54% of women (P = 0.001) and 64% and 51% of men (P = 0.001) were on low-to-moderate-potency LLT. Adherence to LLT was reduced in women older than 55 years, especially in secondary prevention (P = 0.03), where the percentage of women and men with LDL-c > 1.81 mmol/L were 99.9% and 98.9%, respectively (P = 0.001). Women with FH-P are less often treated with high-intensity LLT, less adherent to LLT, and have a lower probability of meeting their LDL-c goals than men, especially in secondary prevention.© 2023. The Author(s).
    Thematic Areas: Zootecnia / recursos pesqueiros Saúde coletiva Química Psicología Odontología Nutrição Multidisciplinary sciences Multidisciplinary Medicina veterinaria Medicina iii Medicina ii Medicina i Materiais Matemática / probabilidade e estatística Letras / linguística Interdisciplinar Geografía Geociências Farmacia Engenharias iv Engenharias iii Engenharias ii Enfermagem Educação física Educação Economia Ciências biológicas iii Ciências biológicas ii Ciências biológicas i Ciências ambientais Ciências agrárias i Ciência de alimentos Ciência da computação Biotecnología Biodiversidade Astronomia / física
    licence for use: https://creativecommons.org/licenses/by/3.0/es/
    Author's mail: luis.masana@urv.cat celia.rodriguez@urv.cat daiana.ibarretxe@urv.cat celia.rodriguez@urv.cat
    Author identifier: 0000-0002-0789-4954
    Record's date: 2024-07-20
    Papper version: info:eu-repo/semantics/publishedVersion
    Link to the original source: https://www.nature.com/articles/s41598-023-27963-z
    Licence document URL: http://repositori.urv.cat/ca/proteccio-de-dades/
    Papper original source: Scientific Reports. 13 (1): 1492-1492
    APA: Zamora, A; Ramos, R; Comas-Cufi, M; García-Gil, M; Martí-Lluch, R; Plana, N; Alves-Cabratosa, L; Ponjoan, A; Rodríguez-Borjabad, C; Ibarretxe, D; Roma (2023). Women with familial hypercholesterolemia phenotype are undertreated and poorly controlled compared to men. Scientific Reports, 13(1), 1492-1492. DOI: 10.1038/s41598-023-27963-z
    Article's DOI: 10.1038/s41598-023-27963-z
    Entity: Universitat Rovira i Virgili
    Journal publication year: 2023
    Publication Type: Journal Publications
  • Keywords:

    Multidisciplinary,Multidisciplinary Sciences
    Coronary-heart-disease
    united-states
    therapy
    sex-differences
    primary-care
    prevalence
    participants
    gender
    disparities
    adherence
    Zootecnia / recursos pesqueiros
    Saúde coletiva
    Química
    Psicología
    Odontología
    Nutrição
    Multidisciplinary sciences
    Multidisciplinary
    Medicina veterinaria
    Medicina iii
    Medicina ii
    Medicina i
    Materiais
    Matemática / probabilidade e estatística
    Letras / linguística
    Interdisciplinar
    Geografía
    Geociências
    Farmacia
    Engenharias iv
    Engenharias iii
    Engenharias ii
    Enfermagem
    Educação física
    Educação
    Economia
    Ciências biológicas iii
    Ciências biológicas ii
    Ciências biológicas i
    Ciências ambientais
    Ciências agrárias i
    Ciência de alimentos
    Ciência da computação
    Biotecnología
    Biodiversidade
    Astronomia / física
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