Author, as appears in the article.: Zamora A; Ramos R; Comas-Cufi M; García-Gil M; Martí-Lluch R; Plana N; Alves-Cabratosa L; Ponjoan A; Rodríguez-Borjabad C; Ibarretxe D; Roman-Degano I; Marrugat J; Elosua R; Martín-Urda A; Masana L

Department: Medicina i Cirurgia

URV's Author/s: Masana Marín, Luis / Plana Gil, Núria

Keywords: Coronary-heart-disease united-states therapy sex-differences primary-care prevalence participants gender disparities adherence

Abstract: Familial hypercholesterolemia (FH) is an autosomal dominant disease that has a prevalence of approximately 1/250 inhabitants and is the most frequent cause of early coronary heart disease (CHD). We included 1.343.973 women and 1.210.671 men with at least one LDL-c measurement from the Catalan primary care database. We identified 14.699 subjects with Familial hypercholesterolemia-Phenotype (FH-P) based on LDL-c cut-off points by age (7.033 and 919 women, and 5.088 and 1659 men in primary and secondary prevention, respectively). Lipid lower therapy (LLT), medication possession ratio (MPR) as an indicator of adherence, and number of patients that reached their goal on lipid levels were compared by sex. In primary and secondary prevention, 69% and 54% of women (P = 0.001) and 64% and 51% of men (P = 0.001) were on low-to-moderate-potency LLT. Adherence to LLT was reduced in women older than 55 years, especially in secondary prevention (P = 0.03), where the percentage of women and men with LDL-c > 1.81 mmol/L were 99.9% and 98.9%, respectively (P = 0.001). Women with FH-P are less often treated with high-intensity LLT, less adherent to LLT, and have a lower probability of meeting their LDL-c goals than men, especially in secondary prevention.© 2023. The Author(s).

Thematic Areas: Zootecnia / recursos pesqueiros Saúde coletiva Química Psicología Odontología Nutrição Multidisciplinary sciences Multidisciplinary Medicina veterinaria Medicina iii Medicina ii Medicina i Materiais Matemática / probabilidade e estatística Letras / linguística Interdisciplinar Geografía Geociências Farmacia Engenharias iv Engenharias iii Engenharias ii Enfermagem Educação física Educação Economia Ciências biológicas iii Ciências biológicas ii Ciências biológicas i Ciências ambientais Ciências agrárias i Ciência de alimentos Ciência da computação Biotecnología Biodiversidade Astronomia / física

licence for use: https://creativecommons.org/licenses/by/3.0/es/

Author's mail: nuria.plana@urv.cat luis.masana@urv.cat

Author identifier: 0000-0002-4231-7618 0000-0002-0789-4954

Record's date: 2023-05-13

Papper version: info:eu-repo/semantics/publishedVersion

Link to the original source: https://www.nature.com/articles/s41598-023-27963-z

Licence document URL: http://repositori.urv.cat/ca/proteccio-de-dades/

Papper original source: Scientific Reports. 13 (1): 1492-1492

APA: Zamora A; Ramos R; Comas-Cufi M; García-Gil M; Martí-Lluch R; Plana N; Alves-Cabratosa L; Ponjoan A; Rodríguez-Borjabad C; Ibarretxe D; Roman-Degano I (2023). Women with familial hypercholesterolemia phenotype are undertreated and poorly controlled compared to men. Scientific Reports, 13(1), 1492-1492. DOI: 10.1038/s41598-023-27963-z

Article's DOI: 10.1038/s41598-023-27963-z

Entity: Universitat Rovira i Virgili

Journal publication year: 2023

Publication Type: Journal Publications