Articles producció científica> Medicina i Cirurgia

The ANGPTL3-4-8 Axis in Normal Gestation and in Gestational Diabetes, and Its Potential Involvement in Fetal Growth

  • Identification data

    Identifier: imarina:9291171
    Authors:
    Klid, SMaymó-Masip, EAlgaba-Chueca, FBallesteros, MInglès-Puig, MGuarque, AMadeira, AJareño, CVendrell, JFernández-Veledo, SMegía, A
    Abstract:
    Dyslipidemia in gestational diabetes has been associated with worse perinatal outcomes. The ANGPTL3-4-8 axis regulates lipid metabolism, especially in the transition from fasting to feeding. In this study, we evaluated the response of ANGPTL3, 4, and 8 after the intake of a mixed meal in women with normal glucose tolerance and gestational diabetes, and we assessed their gene expressions in different placental locations. Regarding the circulating levels of ANGPTL3, 4, and 8, we observed an absence of ANGPTL4 response after the intake of the meal in the GDM group compared to its presence in the control group. At the placental level, we observed a glucose tolerance-dependent expression pattern of ANGPTL3 between the two placental sides. When we compared the GDM pregnancies with the control pregnancies, a downregulation of the maternal side ANGPTL3 expression was observed. This suggests a dysregulation of the ANGPTL3–4–8 axis in GDM, both at the circulating level after ingestion and at the level of placental expression. Furthermore, we discerned that the expressions of ANGPTL3, 4, and 8 were related to birth weight and placental weight in the GDM group, but not in the control group, which suggests that they may play a role in regulating the transplacental passage of nutrients.
  • Others:

    Author, as appears in the article.: Klid, S; Maymó-Masip, E; Algaba-Chueca, F; Ballesteros, M; Inglès-Puig, M; Guarque, A; Madeira, A; Jareño, C; Vendrell, J; Fernández-Veledo, S; Megía, A
    Department: Medicina i Cirurgia Ciències Mèdiques Bàsiques
    URV's Author/s: Ballesteros Pérez, Monica / Fernandez Veledo, Sonia / Guarque Rus, Albert / Klid Klid, Sergiy / Maymo Masip, Elsa / Megía Colet, Ana / Vendrell Ortega, Juan José
    Keywords: Placental endothelial lipase Lipid metabolism Gestational diabetes Fetal growth Angptl protein 8 pregnancy mellitus maternal obesity lipoprotein-lipase lipid-metabolism lipid metabolism improves fetal growth expression dysregulation angptl
    Abstract: Dyslipidemia in gestational diabetes has been associated with worse perinatal outcomes. The ANGPTL3-4-8 axis regulates lipid metabolism, especially in the transition from fasting to feeding. In this study, we evaluated the response of ANGPTL3, 4, and 8 after the intake of a mixed meal in women with normal glucose tolerance and gestational diabetes, and we assessed their gene expressions in different placental locations. Regarding the circulating levels of ANGPTL3, 4, and 8, we observed an absence of ANGPTL4 response after the intake of the meal in the GDM group compared to its presence in the control group. At the placental level, we observed a glucose tolerance-dependent expression pattern of ANGPTL3 between the two placental sides. When we compared the GDM pregnancies with the control pregnancies, a downregulation of the maternal side ANGPTL3 expression was observed. This suggests a dysregulation of the ANGPTL3–4–8 axis in GDM, both at the circulating level after ingestion and at the level of placental expression. Furthermore, we discerned that the expressions of ANGPTL3, 4, and 8 were related to birth weight and placental weight in the GDM group, but not in the control group, which suggests that they may play a role in regulating the transplacental passage of nutrients.
    Thematic Areas: Zootecnia / recursos pesqueiros Spectroscopy Saúde coletiva Química Psicología Physical and theoretical chemistry Organic chemistry Odontología Nutrição Molecular biology Medicine (miscellaneous) Medicina veterinaria Medicina iii Medicina ii Medicina i Materiais Interdisciplinar Inorganic chemistry Geociências Farmacia Engenharias iv Engenharias ii Engenharias i Educação física Computer science applications Ciências biológicas iii Ciências biológicas ii Ciências biológicas i Ciências ambientais Ciências agrárias i Ciência de alimentos Ciência da computação Chemistry, multidisciplinary Catalysis Biotecnología Biodiversidade Biochemistry & molecular biology Astronomia / física
    licence for use: https://creativecommons.org/licenses/by/3.0/es/
    Author's mail: sonia.fernandez@urv.cat albert.guarque@urv.cat elsa.maymo@urv.cat monica.ballesteros@urv.cat sergiy.klidk@estudiants.urv.cat sergiy.klidk@estudiants.urv.cat ana.megia@urv.cat juanjose.vendrell@urv.cat
    Author identifier: 0000-0003-2906-3788 0000-0002-9133-3120 0000-0002-5101-9452 0000-0002-6994-6115
    Record's date: 2024-08-03
    Papper version: info:eu-repo/semantics/publishedVersion
    Link to the original source: https://www.mdpi.com/1422-0067/24/3/2486
    Licence document URL: https://repositori.urv.cat/ca/proteccio-de-dades/
    Papper original source: International Journal Of Molecular Sciences. 24 (3): 2486-
    APA: Klid, S; Maymó-Masip, E; Algaba-Chueca, F; Ballesteros, M; Inglès-Puig, M; Guarque, A; Madeira, A; Jareño, C; Vendrell, J; Fernández-Veledo, S; Megía, (2023). The ANGPTL3-4-8 Axis in Normal Gestation and in Gestational Diabetes, and Its Potential Involvement in Fetal Growth. International Journal Of Molecular Sciences, 24(3), 2486-. DOI: 10.3390/ijms24032486
    Article's DOI: 10.3390/ijms24032486
    Entity: Universitat Rovira i Virgili
    Journal publication year: 2023
    Publication Type: Journal Publications
  • Keywords:

    Biochemistry & Molecular Biology,Catalysis,Chemistry, Multidisciplinary,Computer Science Applications,Inorganic Chemistry,Medicine (Miscellaneous),Molecular Biology,Organic Chemistry,Physical and Theoretical Chemistry,Spectroscopy
    Placental endothelial lipase
    Lipid metabolism
    Gestational diabetes
    Fetal growth
    Angptl
    protein 8
    pregnancy
    mellitus
    maternal obesity
    lipoprotein-lipase
    lipid-metabolism
    lipid metabolism
    improves
    fetal growth
    expression
    dysregulation
    angptl
    Zootecnia / recursos pesqueiros
    Spectroscopy
    Saúde coletiva
    Química
    Psicología
    Physical and theoretical chemistry
    Organic chemistry
    Odontología
    Nutrição
    Molecular biology
    Medicine (miscellaneous)
    Medicina veterinaria
    Medicina iii
    Medicina ii
    Medicina i
    Materiais
    Interdisciplinar
    Inorganic chemistry
    Geociências
    Farmacia
    Engenharias iv
    Engenharias ii
    Engenharias i
    Educação física
    Computer science applications
    Ciências biológicas iii
    Ciências biológicas ii
    Ciências biológicas i
    Ciências ambientais
    Ciências agrárias i
    Ciência de alimentos
    Ciência da computação
    Chemistry, multidisciplinary
    Catalysis
    Biotecnología
    Biodiversidade
    Biochemistry & molecular biology
    Astronomia / física
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