Articles producció científica> Bioquímica i Biotecnologia

Valorization of Chicken Slaughterhouse Byproducts to Obtain Antihypertensive Peptides

  • Identification data

    Identifier: imarina:9291517
    Authors:
    Bravo, FICalvo, ELópez-Villalba, RATorres-Fuentes, CMuguerza, BGarcía-Ruiz, AMorales, D
    Abstract:
    Hypertension (HTN) is the leading cause of premature deaths worldwide and the main preventable risk factor for cardiovascular diseases. Therefore, there is a current need for new therapeutics to manage this condition. In this regard, protein hydrolysates containing antihypertensive bioactive peptides are of increasing interest. Thus, agri-food industry byproducts have emerged as a valuable source to obtain these hydrolysates as they are rich in proteins and inexpensive. Among these, byproducts from animal origin stand out as they are abundantly generated worldwide. Hence, this review is focused on evaluating the potential role of chicken slaughterhouse byproducts as a source of peptides for managing HTN. Several of these byproducts such as blood, bones, skins, and especially, chicken feet have been used to obtain protein hydrolysates with angiotensin-converting enzyme (ACE)-inhibitory activity and blood pressure-lowering effects. An increase in levels of endogenous antioxidant compounds, a reduction in ACE activity, and an improvement of HTN-associated endothelial dysfunction were the mechanisms underlying their effects. However, most of these studies were carried out in animal models, and further clinical studies are needed in order to confirm these antihypertensive properties. This would increase the value of these byproducts, contributing to the circular economy model of slaughterhouses.
  • Others:

    Author, as appears in the article.: Bravo, FI; Calvo, E; López-Villalba, RA; Torres-Fuentes, C; Muguerza, B; García-Ruiz, A; Morales, D
    Department: Bioquímica i Biotecnologia
    URV's Author/s: Bravo Vázquez, Francisca Isabel / Calvo Manso, Enrique / García Ruiz, Almudena / López Villalba, Rafael Ángel / Morales Hernández, Diego / Muguerza Marquínez, Maria Begoña / Torres Fuentes, Cristina
    Keywords: I-converting-enzyme Hypertension Hydrolysates Endothelial dysfunction Blood pressure Angiotensin-converting enzyme-inhibitory activity protein hydrolysate multifunctional ingredient hypertension hydrolysates endothelial dysfunction coronary-heart-disease collagen hydrolysate catalyzed plastein reaction cardiovascular risk blood pressure atherosclerosis risk ace-inhibitory activity
    Abstract: Hypertension (HTN) is the leading cause of premature deaths worldwide and the main preventable risk factor for cardiovascular diseases. Therefore, there is a current need for new therapeutics to manage this condition. In this regard, protein hydrolysates containing antihypertensive bioactive peptides are of increasing interest. Thus, agri-food industry byproducts have emerged as a valuable source to obtain these hydrolysates as they are rich in proteins and inexpensive. Among these, byproducts from animal origin stand out as they are abundantly generated worldwide. Hence, this review is focused on evaluating the potential role of chicken slaughterhouse byproducts as a source of peptides for managing HTN. Several of these byproducts such as blood, bones, skins, and especially, chicken feet have been used to obtain protein hydrolysates with angiotensin-converting enzyme (ACE)-inhibitory activity and blood pressure-lowering effects. An increase in levels of endogenous antioxidant compounds, a reduction in ACE activity, and an improvement of HTN-associated endothelial dysfunction were the mechanisms underlying their effects. However, most of these studies were carried out in animal models, and further clinical studies are needed in order to confirm these antihypertensive properties. This would increase the value of these byproducts, contributing to the circular economy model of slaughterhouses.
    Thematic Areas: Zootecnia / recursos pesqueiros Saúde coletiva Química Psicología Planejamento urbano e regional / demografia Nutrition and dietetics Nutrition & dietetics Nutrição Medicina veterinaria Medicina iii Medicina ii Medicina i Interdisciplinar Food science Farmacia Engenharias iv Engenharias ii Enfermagem Educação física Economia Ciências biológicas iii Ciências biológicas ii Ciências biológicas i Ciências agrárias i Ciência de alimentos Biotecnología
    licence for use: https://creativecommons.org/licenses/by/3.0/es/
    Author's mail: rafaelangel.lopez@urv.cat almudena.garcia@urv.cat franciscaisabel.bravo@urv.cat enrique.calvo@urv.cat rafaelangel.lopez@urv.cat begona.muguerza@urv.cat cristina.torres@urv.cat
    Author identifier: 0000-0002-6468-3088 0000-0001-7384-8588 0000-0002-2917-6910
    Record's date: 2024-08-03
    Papper version: info:eu-repo/semantics/publishedVersion
    Link to the original source: https://www.mdpi.com/2072-6643/15/2/457
    Licence document URL: https://repositori.urv.cat/ca/proteccio-de-dades/
    Papper original source: Nutrients. 15 (2): 457-
    APA: Bravo, FI; Calvo, E; López-Villalba, RA; Torres-Fuentes, C; Muguerza, B; García-Ruiz, A; Morales, D (2023). Valorization of Chicken Slaughterhouse Byproducts to Obtain Antihypertensive Peptides. Nutrients, 15(2), 457-. DOI: 10.3390/nu15020457
    Article's DOI: 10.3390/nu15020457
    Entity: Universitat Rovira i Virgili
    Journal publication year: 2023
    Publication Type: Journal Publications
  • Keywords:

    Food Science,Nutrition & Dietetics,Nutrition and Dietetics
    I-converting-enzyme
    Hypertension
    Hydrolysates
    Endothelial dysfunction
    Blood pressure
    Angiotensin-converting enzyme-inhibitory activity
    protein hydrolysate
    multifunctional ingredient
    hypertension
    hydrolysates
    endothelial dysfunction
    coronary-heart-disease
    collagen hydrolysate
    catalyzed plastein reaction
    cardiovascular risk
    blood pressure
    atherosclerosis risk
    ace-inhibitory activity
    Zootecnia / recursos pesqueiros
    Saúde coletiva
    Química
    Psicología
    Planejamento urbano e regional / demografia
    Nutrition and dietetics
    Nutrition & dietetics
    Nutrição
    Medicina veterinaria
    Medicina iii
    Medicina ii
    Medicina i
    Interdisciplinar
    Food science
    Farmacia
    Engenharias iv
    Engenharias ii
    Enfermagem
    Educação física
    Economia
    Ciências biológicas iii
    Ciências biológicas ii
    Ciências biológicas i
    Ciências agrárias i
    Ciência de alimentos
    Biotecnología
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