Author, as appears in the article.: Bravo, FI; Calvo, E; López-Villalba, RA; Torres-Fuentes, C; Muguerza, B; García-Ruiz, A; Morales, D
Department: Bioquímica i Biotecnologia
URV's Author/s: Bravo Vázquez, Francisca Isabel / Calvo Manso, Enrique / García Ruiz, Almudena / López Villalba, Rafael Ángel / Morales Hernández, Diego / Muguerza Marquínez, Maria Begoña / Torres Fuentes, Cristina
Keywords: I-converting-enzyme Hypertension Hydrolysates Endothelial dysfunction Blood pressure Angiotensin-converting enzyme-inhibitory activity protein hydrolysate multifunctional ingredient hypertension hydrolysates endothelial dysfunction coronary-heart-disease collagen hydrolysate catalyzed plastein reaction cardiovascular risk blood pressure atherosclerosis risk ace-inhibitory activity
Abstract: Hypertension (HTN) is the leading cause of premature deaths worldwide and the main preventable risk factor for cardiovascular diseases. Therefore, there is a current need for new therapeutics to manage this condition. In this regard, protein hydrolysates containing antihypertensive bioactive peptides are of increasing interest. Thus, agri-food industry byproducts have emerged as a valuable source to obtain these hydrolysates as they are rich in proteins and inexpensive. Among these, byproducts from animal origin stand out as they are abundantly generated worldwide. Hence, this review is focused on evaluating the potential role of chicken slaughterhouse byproducts as a source of peptides for managing HTN. Several of these byproducts such as blood, bones, skins, and especially, chicken feet have been used to obtain protein hydrolysates with angiotensin-converting enzyme (ACE)-inhibitory activity and blood pressure-lowering effects. An increase in levels of endogenous antioxidant compounds, a reduction in ACE activity, and an improvement of HTN-associated endothelial dysfunction were the mechanisms underlying their effects. However, most of these studies were carried out in animal models, and further clinical studies are needed in order to confirm these antihypertensive properties. This would increase the value of these byproducts, contributing to the circular economy model of slaughterhouses.
Thematic Areas: Zootecnia / recursos pesqueiros Saúde coletiva Química Psicología Planejamento urbano e regional / demografia Nutrition and dietetics Nutrition & dietetics Nutrição Medicina veterinaria Medicina iii Medicina ii Medicina i Interdisciplinar Food science Farmacia Engenharias iv Engenharias ii Enfermagem Educação física Economia Ciências biológicas iii Ciências biológicas ii Ciências biológicas i Ciências agrárias i Ciência de alimentos Biotecnología
licence for use: https://creativecommons.org/licenses/by/3.0/es/
Author's mail: rafaelangel.lopez@urv.cat almudena.garcia@urv.cat franciscaisabel.bravo@urv.cat enrique.calvo@urv.cat rafaelangel.lopez@urv.cat begona.muguerza@urv.cat cristina.torres@urv.cat
Author identifier: 0000-0002-6468-3088 0000-0001-7384-8588 0000-0002-2917-6910
Record's date: 2024-08-03
Papper version: info:eu-repo/semantics/publishedVersion
Link to the original source: https://www.mdpi.com/2072-6643/15/2/457
Licence document URL: https://repositori.urv.cat/ca/proteccio-de-dades/
Papper original source: Nutrients. 15 (2): 457-
APA: Bravo, FI; Calvo, E; López-Villalba, RA; Torres-Fuentes, C; Muguerza, B; García-Ruiz, A; Morales, D (2023). Valorization of Chicken Slaughterhouse Byproducts to Obtain Antihypertensive Peptides. Nutrients, 15(2), 457-. DOI: 10.3390/nu15020457
Article's DOI: 10.3390/nu15020457
Entity: Universitat Rovira i Virgili
Journal publication year: 2023
Publication Type: Journal Publications