Author, as appears in the article.: Gayathri, R; Abirami, K; Kalpana, N; Manasa, VS; Sudha, V; Shobana, S; Jeevan, RG; Kavitha, V; Parkavi, K; Anjana, RM; Unnikrishnan, R; Gokulakrishnan, K; Beatrice, DA; Krishnaswamy, K; Pradeepa, R; Mattes, RD; Salas-Salvadó, J; Willett, W; Mohan, V
Department: Bioquímica i Biotecnologia
URV's Author/s: Salas Salvadó, Jorge
Keywords: Serum lipid Overweight and obesity Insulin sensitivity Insulin resistance Cardiovascular risk-factors Asian–indian Almond type-2 serum lipid resistance profiles prevention overweight and obesity nuts insulin sensitivity insulin resistance glucose dose-response diet body-weight asian-indian
Abstract: Background: Asian Indians have an increased susceptibility to type 2 diabetes and premature coronary artery disease. Nuts, like almonds, are rich in unsaturated fat and micronutrients with known health benefits. Objectives: This study aimed to assess the efficacy of almonds for reduction of insulin resistance and improving lipid profile in overweight Asian Indian adults. Methods: This parallel-arm, randomized, controlled trial was conducted in Chennai, India on 400 participants aged 25–65 years with a body mass index ≥ 23 kg/m2. The intervention group received 43 g of almonds/day for 12 weeks, while the control group was advised to consume a customary diet but to avoid nuts. Anthropometric, clinical, and dietary data were assessed at periodic intervals. Glucose tolerance, serum insulin, glycated hemoglobin, C-peptide and lipid profile were assessed at baseline and end of the study. Insulin resistance (homeostasis assessment model-HOMA IR) and oral insulin disposition index (DIo) were calculated. Results: A total of 352 participants completed the study. Significant improvement was seen in DIo [mean (95% CI) = + 0.7 mmol/L (0.1, 1.3); p = 0.03], HOMA IR (−0.4 (−0.7, −0.04; p = 0.03) and total cholesterol (−5.4 mg/dl (−10.2, −0.6); p = 0.03) in the intervention group compared to the control group. Incremental area under the curve (IAUC) and mean amplitude of glycemic excursion (MAGE) assessed using continuous glucose monitoring systems were also significantly lower in the intervention group. Dietary 24-h recalls showed a higher significant reduction in carbohydrate and increase in mono unsaturated fatty acid (MUFA) and polyunsaturated fatty acids (PUFA) intake in the intervention group compared to the control group. Conclusion: Daily consumption of almonds increased the intake of MUFA with decrease in carbohydrate calories and decreases insulin resistance, improves insulin sensitivity and lowers serum cholesterol in Asian Indians with overweight/obesity. These effects in the long run could aid in reducing the risk of diabetes and other cardiometabolic disease.
Thematic Areas: Saúde coletiva Nutrition and dietetics Nutrition & dietetics Nutrição Medicina i Interdisciplinar Food science Endocrinology, diabetes and metabolism Educação física
licence for use: https://creativecommons.org/licenses/by/3.0/es/
Author's mail: jordi.salas@urv.cat
Author identifier: 0000-0003-2700-7459
Record's date: 2024-08-03
Papper version: info:eu-repo/semantics/publishedVersion
Link to the original source: https://www.frontiersin.org/articles/10.3389/fnut.2022.1055923/full
Licence document URL: https://repositori.urv.cat/ca/proteccio-de-dades/
Papper original source: Front Nutr. 9
APA: Gayathri, R; Abirami, K; Kalpana, N; Manasa, VS; Sudha, V; Shobana, S; Jeevan, RG; Kavitha, V; Parkavi, K; Anjana, RM; Unnikrishnan, R; Gokulakrishnan (2023). Effect of almond consumption on insulin sensitivity and serum lipids among Asian Indian adults with overweight and obesity– A randomized controlled trial. Front Nutr, 9(), -. DOI: 10.3389/fnut.2022.1055923
Article's DOI: 10.3389/fnut.2022.1055923
Entity: Universitat Rovira i Virgili
Journal publication year: 2023
Publication Type: Journal Publications
Repositori URV