Articles producció científica> Medicina i Cirurgia

Transient viral rebound in children with perinatally acquired HIV-1 induces a unique soluble immunometabolic signature associated with decreased CD4/CD8 ratio

  • Identification data

    Identifier: imarina:9291542
    Handle: https://hdl.handle.net/20.500.11797/imarina9291542
    Authors:
    Tarancon-Diez, LPeraire, Jde Ory, SJGuirro, MEscosa, LTato, LMPAntón, MPPiqueras, AIPérez, AVGavilán, CBustillo-Alonso, MNavarro, MLViladés, CVidal, FRull, AMuñoz-Fernández, MA
    Abstract:
    To determine by multi-omic analysis changes in metabolites, lipids and proteins as consequence of transient viral rebound (tVR) in children with perinatally acquired HIV-1 (PHIV).Plasma samples from children with PHIV and with tVR (first episode of transient RNA-HIV viral load >20 copies/ml followed by suppression) on the time-point immediately before (pre-tVR) and after (post-tVR) the tVR were assessed. Multi-omic analyses were performed using nLC-Orbitrap, GC-qTOF-MS and LC-qTOF-MS.Comparing pre- and post-tVR time-points, HIV-1-children with tVR (n=5) showed a trend to a decrease in ratio CD4/CD8 (p=0.08) but no significant differences were observed in plasma metabolites, lipids or proteins. Post-tVR condition was compared with a reference group of children with PHIV with persistent viral control (n=9), paired by sex, age and time under antiretroviral treatment. A total of 10 proteins, 8 metabolites and 2 lipids showed significant differences (p<0.05): serotransferrin, clusterin, kininogen-1, succinic acid, threonine, 2-hydroxyisovaleric acid, methionine, 2-hydroxyglutaric, triacylglyceride 50:0 (TG50:0) and diacylglyceride 34:1 (DG34:1) were up-regulated while alpha-2-macroglobulin, apolipoprotein A-II, carboxylic ester hydrolase, apolipoprotein D, coagulation factor IX, peptidase inhibitor 16, SAA2-SAA4 readthrough, oleic acid, palmitoleic acid and D-sucrose downregulated on post-tVR time-point compared to reference group. Ratio CD4/CD8 correlated with apolipoprotein A-II, DG34:1 and methionine (p=0.004;ρ=0.71, p=0.016;ρ=-0.63 and p=0.032;ρ=-0.57, respectively). Nadir CD4+ correlated inversely with kininogen-1 (p=0.022;ρ=-0.60) and positively with D-sucrose (p=0.001;ρ=0.77).tVR followed by suppression implies changes in soluble proteins, lipids and metabolites that

  • Others:

    Author, as appears in the article.: Tarancon-Diez, L; Peraire, J; de Ory, SJ; Guirro, M; Escosa, L; Tato, LMP; Antón, MP; Piqueras, AI; Pérez, AV; Gavilán, C; Bustillo-Alonso, M; Navarro, ML; Viladés, C; Vidal, F; Rull, A; Muñoz-Fernández, MA
    Department: Medicina i Cirurgia
    URV's Author/s: Aguirre Torres, Gorki Dimitrov / Peraire Forner, José Joaquin / RULL AIXA, ANNA / Vidal Marsal, Francisco / Vilades Laborda, Consuelo Gloria
    Keywords: Viral rebounds Vertically hiv-1-children Ratio cd4/cd8 Omics Early antiretroviral therapy viral rebounds vertically hiv-1 children ratio cd4 low-level viremia load cd8 blips adherence
    Abstract: To determine by multi-omic analysis changes in metabolites, lipids and proteins as consequence of transient viral rebound (tVR) in children with perinatally acquired HIV-1 (PHIV).Plasma samples from children with PHIV and with tVR (first episode of transient RNA-HIV viral load >20 copies/ml followed by suppression) on the time-point immediately before (pre-tVR) and after (post-tVR) the tVR were assessed. Multi-omic analyses were performed using nLC-Orbitrap, GC-qTOF-MS and LC-qTOF-MS.Comparing pre- and post-tVR time-points, HIV-1-children with tVR (n=5) showed a trend to a decrease in ratio CD4/CD8 (p=0.08) but no significant differences were observed in plasma metabolites, lipids or proteins. Post-tVR condition was compared with a reference group of children with PHIV with persistent viral control (n=9), paired by sex, age and time under antiretroviral treatment. A total of 10 proteins, 8 metabolites and 2 lipids showed significant differences (p<0.05): serotransferrin, clusterin, kininogen-1, succinic acid, threonine, 2-hydroxyisovaleric acid, methionine, 2-hydroxyglutaric, triacylglyceride 50:0 (TG50:0) and diacylglyceride 34:1 (DG34:1) were up-regulated while alpha-2-macroglobulin, apolipoprotein A-II, carboxylic ester hydrolase, apolipoprotein D, coagulation factor IX, peptidase inhibitor 16, SAA2-SAA4 readthrough, oleic acid, palmitoleic acid and D-sucrose downregulated on post-tVR time-point compared to reference group. Ratio CD4/CD8 correlated with apolipoprotein A-II, DG34:1 and methionine (p=0.004;ρ=0.71, p=0.016;ρ=-0.63 and p=0.032;ρ=-0.57, respectively). Nadir CD4+ correlated inversely with kininogen-1 (p=0.022;ρ=-0.60) and positively with D-sucrose (p=0.001;ρ=0.77).tVR followed by suppression implies changes in soluble proteins, lipids and metabolites that correlate with immunological parameters, mainly ratio CD4/CD8, that decreased after tVR. These distinct soluble biomarkers could be considered potential biomarkers of immune progression.© The Author(s) 2023. Published by Oxford University Press on behalf of The Journal of the Pediatric Infectious Diseases Society.
    Thematic Areas: Saúde coletiva Pediatrics, perinatology and child health Pediatrics Medicine (miscellaneous) Medicine (all) Medicina ii Medicina i Infectious diseases General medicine
    licence for use: https://creativecommons.org/licenses/by/3.0/es/
    Author's mail: joaquim.peraire@urv.cat consuelo.vilades@urv.cat gorki.aguirre@estudiants.urv.cat francesc.vidal@urv.cat
    Author identifier: 0000-0001-7808-5479 0000-0002-2991-9593 0000-0002-8812-3093 0000-0002-6692-6186
    Record's date: 2024-08-03
    Papper version: info:eu-repo/semantics/publishedVersion
    Link to the original source: https://academic.oup.com/jpids/article/12/3/143/7024335?login=false
    Licence document URL: https://repositori.urv.cat/ca/proteccio-de-dades/
    Papper original source: Journal Of The Pediatric Infectious Diseases Society. 12 (3): piad008-piad008
    APA: Tarancon-Diez, L; Peraire, J; de Ory, SJ; Guirro, M; Escosa, L; Tato, LMP; Antón, MP; Piqueras, AI; Pérez, AV; Gavilán, C; Bustillo-Alonso, M; Navarro (2023). Transient viral rebound in children with perinatally acquired HIV-1 induces a unique soluble immunometabolic signature associated with decreased CD4/CD8 ratio. Journal Of The Pediatric Infectious Diseases Society, 12(3), piad008-piad008. DOI: 10.1093/jpids/piad008
    Article's DOI: 10.1093/jpids/piad008
    Entity: Universitat Rovira i Virgili
    Journal publication year: 2023
    Publication Type: Journal Publications

  • Keywords:

    Infectious Diseases,Medicine (Miscellaneous),Pediatrics,Pediatrics, Perinatology and Child Health
    Viral rebounds
    Vertically hiv-1-children
    Ratio cd4/cd8
    Omics
    Early antiretroviral therapy
    viral rebounds
    vertically hiv-1 children
    ratio cd4
    low-level viremia
    load
    cd8
    blips
    adherence
    Saúde coletiva
    Pediatrics, perinatology and child health
    Pediatrics
    Medicine (miscellaneous)
    Medicine (all)
    Medicina ii
    Medicina i
    Infectious diseases
    General medicine

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