Author, as appears in the article.: Iglesias-Vázquez, L; Gimeno, M; Coronel, P; Caspersen, IH; Basora, J; Arija, V
Department: Ciències Mèdiques Bàsiques
URV's Author/s: Arija Val, Maria Victoria / Basora Gallisa, Josep / Iglesias Vazquez, Lucia
Keywords: Serum ferritin Prenatal Maternal Iron status Iron deficiency Hfe c282y Haemoglobin serum ferritin risk maternal iron status iron deficiency hemochromatosis haemoglobin
Abstract: Several population-specific genetic, sociodemographic, and maternal lifestyle factors are related to iron status in early pregnancy, and their identification would allow preventive actions to be taken. The study aimed to identify maternal factors associated with iron deficiency (ID) in early pregnancy in non-anaemic pregnant women from a European Mediterranean country. Cross-sectional study using the initial population of the ECLIPSES study performed in non-anaemic pregnant women before gestational week 12. Serum ferritin (SF) and haemoglobin concentrations were measured to evaluate iron status, and ID was defined as SF < 15 µg/L. Several sociodemographic and lifestyle data were recorded and used as covariates in the multivariate-adjusted regression models. Out of the 791 participants, 13.9% had ID in early pregnancy. Underweight (OR 3.70, 95%CI 1.22, 15.53) and parity (1 child: OR 2.03, 95%CI 1.06, 3.88; ≥ 2 children: OR 6.96, 95%CI 3.09, 15.69) increased the odds of ID, while a high intake of total meat (≥ 108.57 g/day: OR 0.37, 95%CI 0.15, 0.87), red/processed meat (≥ 74.29 g/day: OR 0.70, 95%CI 0.35, 0.98), protein (≥ 65.05 g/day: OR 0.85, 95%CI 0.30, 0.99), and dietary iron (≥ 8.58 mg/day: OR 0.58, 95%CI 0.35, 0.94) protected against it. Smoking was also associated with a reduction in ID odds (OR 0.34, 95%CI 0.12, 0.99). Baseline BMI, parity, smoking, and diet are associated with ID in early pregnancy in non-anaemic women. Pregnancy planning policies should focus on women at higher risk of ID, such as those who are underweight, multiparous, or following vegetarian diets. This clinical trial was registered at www.clinicaltrialsregister.eu as EudraCT number 2012-005,480-28 and at www.clinicaltrials.gov with identification number NCT03196882.© 2023. The Author(s).
Thematic Areas: Saúde coletiva Química Odontología Medicine (miscellaneous) Medicina iii Medicina ii Medicina i Interdisciplinar Hematology General medicine Farmacia Ciências biológicas iii Ciências biológicas ii Ciências biológicas i Biotecnología
licence for use: https://creativecommons.org/licenses/by/3.0/es/
Author's mail: lucia.iglesias@urv.cat josep.basora@urv.cat victoria.arija@urv.cat josep.basora@urv.cat lucia.iglesias@urv.cat
Author identifier: 0000-0001-7131-4144 0000-0002-1758-0975 0000-0001-7131-4144
Record's date: 2023-12-17
Papper version: info:eu-repo/semantics/publishedVersion
Link to the original source: https://link.springer.com/article/10.1007/s00277-023-05123-7
Licence document URL: http://repositori.urv.cat/ca/proteccio-de-dades/
Papper original source: Annals Of Hematology. 102 (4): 741-748
APA: Iglesias-Vázquez, L; Gimeno, M; Coronel, P; Caspersen, IH; Basora, J; Arija, V (2023). Maternal factors associated with iron deficiency without anaemia in early pregnancy: ECLIPSES study. Annals Of Hematology, 102(4), 741-748. DOI: 10.1007/s00277-023-05123-7
Article's DOI: 10.1007/s00277-023-05123-7
Entity: Universitat Rovira i Virgili
Journal publication year: 2023
Publication Type: Journal Publications
Repositori URV