Author, as appears in the article.: Parada-Ricart, E; Ferre, N; Luque, V; Gruszfeld, D; Gradowska, K; Closa-Monasterolo, R; Koletzko, B; Grote, V; Subías, JE
Department: Medicina i Cirurgia
URV's Author/s: Closa Monasterolo, Ricardo / Escribano Subías, Joaquín / Ferre Pallas, Natalia / Luque Moreno, Verònica / Parada Ricart, Esther
Keywords: blood pressure child children formula growth nephron number protein Blood pressure Child Kidney Low-birth-weight Protein
Abstract: High protein intake has been associated with kidney hypertrophy, which is usually reversible; however, when it occurs early in life, it could lead to cell programming with a long-lasting effect. This study aimed to assess whether higher protein ingestion early in life has a persistent effect on kidney volume at 11 years of age, as well as its influence on blood pressure. This is a secondary analysis of a randomized control trial that compared the growth of infants fed with a higher-protein formula versus those fed with a lower-protein formula, with a control group of breastfed infants. Renal ultrasound and anthropometric measurements were assessed at 6 months and 11 years of age. At 11 years, urinary protein, albumin and creatinine, and blood pressure were measured in 232 children. Feeding with a higher-protein formula was associated with a larger kidney volume (β = 8.71, 95%CI 0.09–17.33, p = 0.048) and higher systolic blood pressure (β = 3.43, 95%CI 0.78–6.08, p = 0.011) at 11 years of age. Microalbuminuria was detected in 7% of the patients, with no differences among groups (p = 0.56). The effect of increased protein ingestion early in life may condition kidney volume and blood pressure in later childhood.
Thematic Areas: Biotecnología Ciência de alimentos Ciências agrárias i Ciências biológicas i Ciências biológicas ii Ciências biológicas iii Economia Educação física Enfermagem Engenharias ii Engenharias iv Farmacia Food science Interdisciplinar Medicina i Medicina ii Medicina iii Medicina veterinaria Nutrição Nutrition & dietetics Nutrition and dietetics Planejamento urbano e regional / demografia Psicología Química Saúde coletiva Zootecnia / recursos pesqueiros
licence for use: https://creativecommons.org/licenses/by/3.0/es/
Author's mail: ricardo.closa@urv.cat natalia.ferre@urv.cat joaquin.escribano@urv.cat veronica.luque@urv.cat esther.parada@urv.cat
Author identifier: 0000-0002-9963-4163 0000-0002-2838-1525 0000-0002-5041-459X 0000-0003-2615-8175
Record's date: 2024-01-13
Papper version: info:eu-repo/semantics/publishedVersion
Link to the original source: https://www.mdpi.com/2072-6643/15/4/874
Papper original source: Nutrients. 15 (4):
APA: Parada-Ricart, E; Ferre, N; Luque, V; Gruszfeld, D; Gradowska, K; Closa-Monasterolo, R; Koletzko, B; Grote, V; Subías, JE (2023). Effect of Protein Intake Early in Life on Kidney Volume and Blood Pressure at 11 Years of Age. Nutrients, 15(4), -. DOI: 10.3390/nu15040874
Licence document URL: http://repositori.urv.cat/ca/proteccio-de-dades/
Article's DOI: 10.3390/nu15040874
Entity: Universitat Rovira i Virgili
Journal publication year: 2023
Publication Type: Journal Publications
Repositori URV