Author, as appears in the article.: Navarro-Masip, E; Colom-Pellicer, M; Manocchio, F; Arola-Arnal, A; Bravo, FI; Muguerza, B; Aragonès, G
Department: Bioquímica i Biotecnologia
URV's Author/s: Aragonès Bargalló, Gerard / Arola Arnal, Anna / Bravo Vázquez, Francisca Isabel / Colom Pellicer, Marina / Manocchio, Francesca / Muguerza Marquínez, Maria Begoña / Navarro Masip, Èlia
Keywords: Seasonal rhythms Polyphenols Gspe Flavonoids Bat Adiponectin seasonal rhythms gspe flavonoids extract expression bat
Abstract: Seasonal rhythms drive metabolic adaptations that influence body weight and adiposity. Adipose tissue is a key regulator of energy homeostasis in the organism, and its healthiness is needed to prevent the major consequences of overweight and obesity. In this context, supplementation with proanthocyanidins has been postulated as a potential strategy to prevent the alterations caused by obesity. Moreover, the effects of these (poly)phenols on metabolism are photoperiod dependent. In order to describe the impact of grape-seed proanthocyanidins extract (GSPE) on important markers of adipose tissue functionality under an obesogenic environment, we exposed Fischer 344 rats to three different photoperiods and fed them a cafeteria diet for five weeks. Afterwards, we supplemented them with 25 mg GSPE/kg/day for four weeks. Our results revealed that GSPE supplementation prevented excessive body weight gain under a long photoperiod, which could be explained by increased lipolysis in the adipose tissue. Moreover, cholesterol and non-esterified fatty acids (NEFAs) serum concentrations were restored by GSPE under standard photoperiod. GSPE consumption slightly helped combat the obesity-induced hypertrophy in adipocytes, and adiponectin mRNA levels were upregulated under all photoperiods. Overall, the administration of GSPE helped reduce the impact of obesity in the adipose tissue, depending on the photoperiod at which GSPE was consumed and on the type of adipose depots.
Thematic Areas: Zootecnia / recursos pesqueiros Saúde coletiva Química Psicología Planejamento urbano e regional / demografia Nutrition and dietetics Nutrition & dietetics Nutrição Medicina veterinaria Medicina iii Medicina ii Medicina i Interdisciplinar Food science Farmacia Engenharias iv Engenharias ii Enfermagem Educação física Economia Ciências biológicas iii Ciências biológicas ii Ciências biológicas i Ciências agrárias i Ciência de alimentos Biotecnología
licence for use: https://creativecommons.org/licenses/by/3.0/es/
Author's mail: marina.colom@urv.cat marina.colom@urv.cat marina.colom@urv.cat francesca.manocchio@urv.cat francesca.manocchio@urv.cat francesca.manocchio@urv.cat elia.navarro@estudiants.urv.cat elia.navarro@estudiants.urv.cat franciscaisabel.bravo@urv.cat anna.arola@urv.cat gerard.aragones@urv.cat begona.muguerza@urv.cat
Author identifier: 0000-0002-6468-3088 0000-0001-6529-1345 0000-0001-7384-8588
Record's date: 2024-09-21
Papper version: info:eu-repo/semantics/publishedVersion
Link to the original source: https://www.mdpi.com/2072-6643/15/4/1037
Licence document URL: https://repositori.urv.cat/ca/proteccio-de-dades/
Papper original source: Nutrients. 15 (4):
APA: Navarro-Masip, E; Colom-Pellicer, M; Manocchio, F; Arola-Arnal, A; Bravo, FI; Muguerza, B; Aragonès, G (2023). Grape-Seed Proanthocyanidins Modulate Adipose Tissue Adaptations to Obesity in a Photoperiod-Dependent Manner in Fischer 344 Rats. Nutrients, 15(4), -. DOI: 10.3390/nu15041037
Article's DOI: 10.3390/nu15041037
Entity: Universitat Rovira i Virgili
Journal publication year: 2023
Publication Type: Journal Publications