Author, as appears in the article.: Bini, Simone; D'Erasmo, Laura; Astiarraga, Brenno; Minicocci, Ilenia; Palumbo, Maria; Pecce, Valeria; Polito, Luca; Di Costanzo, Alessia; Haeusler, Rebecca A.; Arca, Marcello; Ferrannini, Ele; Camastra, Stefania;
Department: Bioquímica i Biotecnologia
URV's Author/s: Domínguez Porfirio, Brenno
Keywords: Angiopoietin-like protein-3 Angptl3 Angptl4 Bariatric surgery Insulin sensitivity Lipid metabolism Liver Type 2 diabetes mellitus
Abstract: Background and aim: Angiopoietin-like 3 (ANGPTL3) and 4 (ANGPTL4) are regulators of triglyceride storage and utilization. Bariatric surgery (BS) leads to profound changes in adipose tissue composition and energy metabolism. We evaluated the impact of BS on plasma levels of ANGPTL3 and ANGPTL4.Methods and results: Twenty-seven subjects affected by morbid obesity with or without type 2 diabetes (T2D) underwent Roux-en-Y gastric bypass (RYGB) and 18 patients with advanced T2D received Biliopancreatic Diversion (BPD). Fasting ANGPTL proteins levels, insulin sensitivity (evaluated by euglycemic hyperinsulinemic clamp), total bile acids (TBA) and free fatty acids (FFA) were measured at baseline and 1 year after surgery.Both surgical procedures resulted in the loss of fat mass, improved glucose control, and a -2-fold increase of insulin sensitivity. ANGPTL4 levels decreased significantly with both RYGB (26.6 +/- 0.6 to 24.4 +/- 0.3 ng/mL, p = 0.001) and BPD (27.9 +/- 1.5 to 24.0 +/- 0.5 ng/mL, p = 0.003). In contrast, ANGPTL3 concentrations did not change after RYGB but rose following BPD (225 +/- 20 to 300 +/- 15 ng/mL, p = 0.003). By multiple regression analysis, changes after BS in ANGPTL4 were independently associated with changes in blood glucose, (p = 0.0169) whereas changes in ANGPTL3 were associated with variations in FFA (p = 0.008) and insulin sensitivity (p = 0.043).Conclusion: Circulating ANGPTL4 is reduced by BS, probably due to the loss of fat mass and improved insulin sensitivity. Conversely, ANGPTL3 levels increased after BPD, but not after RYGB, presumably because of the metabolic changes induced by the malabsorptive effect of BPD.(c) 2022 The Italian Diabetes Society, the Italian Society for the Study of Atherosclerosis, the Ital-ian Society of Human Nutrition and the Department of Clinical Medicine and Surgery, Federico II University. Published by Elsevier B.V. All rights reserved.
Thematic Areas: Cardiac & cardiovascular systems Cardiology and cardiovascular medicine Ciências ambientais Ciências biológicas i Ciências biológicas ii Educação física Endocrinology & metabolism Endocrinology, diabetes and metabolism Enfermagem Farmacia General medicine Interdisciplinar Medicina i Medicina ii Medicina iii Medicina veterinaria Medicine (miscellaneous) Nutrição Nutrition & dietetics Nutrition and dietetics Saúde coletiva Serviço social
licence for use: https://creativecommons.org/licenses/by/3.0/es/
Author's mail: brenno.dominguez@urv.cat
Author identifier: 0000-0003-2216-8974
Record's date: 2023-03-18
Papper version: info:eu-repo/semantics/acceptedVersion
Link to the original source: https://www.nmcd-journal.com/article/S0939-4753(22)00366-0/fulltext#%20
Papper original source: Nutrition Metabolism And Cardiovascular Diseases. 32 (11): 2647-2654
APA: Bini, Simone; D'Erasmo, Laura; Astiarraga, Brenno; Minicocci, Ilenia; Palumbo, Maria; Pecce, Valeria; Polito, Luca; Di Costanzo, Alessia; Haeusler, Re (2022). Differential effects of bariatric surgery on plasma levels of ANGPTL3 and ANGPTL4. Nutrition Metabolism And Cardiovascular Diseases, 32(11), 2647-2654. DOI: 10.1016/j.numecd.2022.08.019
Licence document URL: http://repositori.urv.cat/ca/proteccio-de-dades/
Article's DOI: 10.1016/j.numecd.2022.08.019
Entity: Universitat Rovira i Virgili
Journal publication year: 2022
Publication Type: Journal Publications
Repositori URV