Articles producció científica> Medicina i Cirurgia

Coeliac Disease Case-Control Study: Has the Time Come to Explore beyond Patients at Risk?

  • Identification data

    Identifier: imarina:9294208
    Handle: http://hdl.handle.net/20.500.11797/imarina9294208
  • Authors:

    Castillejo, Gemma
    Ochoa-Sangrador, Carlos
    Perez-Solis, David
    Cilleruelo, Maria Luz
    Donat, Ester
    Garcia-Burriel, Jose Ignacio
    Sanchez-Valverde, Felix
    Garcia-Calatayud, Salvador
    Eizaguirre, Francisco Javier
    Martinez-Ojinaga, Eva
    Barros, Patricia
    Leis, Rosaura
    Salazar, Jose Carlos
    Barrio, Josefa
    Pena-Quintana, Luis
    Luque, Veronica
    Polanco, Isabel
    Ribes, Carmen
    Roman, Enriqueta
  • Others:

    Author, as appears in the article.: Castillejo, Gemma; Ochoa-Sangrador, Carlos; Perez-Solis, David; Cilleruelo, Maria Luz; Donat, Ester; Garcia-Burriel, Jose Ignacio; Sanchez-Valverde, Felix; Garcia-Calatayud, Salvador; Eizaguirre, Francisco Javier; Martinez-Ojinaga, Eva; Barros, Patricia; Leis, Rosaura; Salazar, Jose Carlos; Barrio, Josefa; Pena-Quintana, Luis; Luque, Veronica; Polanco, Isabel; Ribes, Carmen; Roman, Enriqueta;
    Department: Medicina i Cirurgia
    URV's Author/s: Castillejo De Villasante, Gemma / Luque Moreno, Verònica
    Keywords: Adolescents Children Coeliac disease Consequences Diagnosis Follow-up General practice Health-care services Long-term health Pediatric gastroenterology Population Prevalence Quality-of-life Screening
    Abstract: The worldwide prevalence of asymptomatic coeliac disease (CD) is increasing, which is in part due to the routine screening of children with risk factors. Both symptomatic and asymptomatic patients with CD are at risk of long-term complications. The objective of this study was to compare the clinical characteristics of asymptomatic and symptomatic children at the time of CD diagnosis. A case-control study was conducted using data from a cohort of 4838 CD patients recruited from 73 centers across Spain between 2011 and 2017. A total of 468 asymptomatic patients (cases) were selected and matched by age and sex with 468 symptomatic patients (controls). Clinical data, including any reported symptoms, as well as serologic, genetic, and histopathologic data were collected. No significant differences were found between the two groups in most clinical variables, nor in the degree of intestinal lesion. However, the asymptomatic patients were taller (height z-score -0.12 (1.06) vs. -0.45 (1.19), p < 0.001) and were less likely to have anti transglutaminase IgA antibodies >= 10 times the upper normal limit (66.2% vs. 758.4%, p = 0.002). Among the 37.1% of asymptomatic patients who were not screened for CD due to the absence of risk factors, only 34% were truly asymptomatic, while the remaining 66% reported non-specific CD-related symptoms. Therefore, expanding CD screening to any child who undergoes a blood test could reduce the burden of care for some children, as many of those considered asymptomatic reported non-specific CD-related symptoms.
    Thematic Areas: Biotecnología Ciência de alimentos Ciências agrárias i Ciências biológicas i Ciências biológicas ii Ciências biológicas iii Economia Educação física Enfermagem Engenharias ii Engenharias iv Farmacia Food science Interdisciplinar Medicina i Medicina ii Medicina iii Medicina veterinaria Nutrição Nutrition & dietetics Nutrition and dietetics Planejamento urbano e regional / demografia Psicología Química Saúde coletiva Zootecnia / recursos pesqueiros
    licence for use: https://creativecommons.org/licenses/by/3.0/es/
    Author's mail: veronica.luque@urv.cat gemma.castillejo@urv.cat
    Author identifier: 0000-0003-2615-8175
    Record's date: 2023-03-25
    Papper version: info:eu-repo/semantics/publishedVersion
    Link to the original source: https://www.mdpi.com/2072-6643/15/5/1267
    Papper original source: Nutrients. 15 (5):
    APA: Castillejo, Gemma; Ochoa-Sangrador, Carlos; Perez-Solis, David; Cilleruelo, Maria Luz; Donat, Ester; Garcia-Burriel, Jose Ignacio; Sanchez-Valverde, F (2023). Coeliac Disease Case-Control Study: Has the Time Come to Explore beyond Patients at Risk?. Nutrients, 15(5), -. DOI: 10.3390/nu15051267
    Licence document URL: http://repositori.urv.cat/ca/proteccio-de-dades/
    Article's DOI: 10.3390/nu15051267
    Entity: Universitat Rovira i Virgili
    Journal publication year: 2023
    Publication Type: Journal Publications
  • Keywords:

    Food Science,Nutrition & Dietetics,Nutrition and Dietetics
    Adolescents
    Children
    Coeliac disease
    Consequences
    Diagnosis
    Follow-up
    General practice
    Health-care services
    Long-term health
    Pediatric gastroenterology
    Population
    Prevalence
    Quality-of-life
    Screening
    Biotecnología
    Ciência de alimentos
    Ciências agrárias i
    Ciências biológicas i
    Ciências biológicas ii
    Ciências biológicas iii
    Economia
    Educação física
    Enfermagem
    Engenharias ii
    Engenharias iv
    Farmacia
    Food science
    Interdisciplinar
    Medicina i
    Medicina ii
    Medicina iii
    Medicina veterinaria
    Nutrição
    Nutrition & dietetics
    Nutrition and dietetics
    Planejamento urbano e regional / demografia
    Psicología
    Química
    Saúde coletiva
    Zootecnia / recursos pesqueiros
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