Author, as appears in the article.: Castillejo, G; Ochoa-Sangrador, C; Perez-Solis, D; Cilleruelo, ML; Donat, E; Garcia-Burriel, JI; Sanchez-Valverde, F; Garcia-Calatayud, S; Eizaguirre, FJ; Martinez-Ojinaga, E; Barros, P; Leis, R; Salazar, JC; Barrio, J; Pena-Quintana, L; Luque, V; Polanco, I; Ribes, C; Roman, E
Department: Medicina i Cirurgia
URV's Author/s: Castillejo De Villasante, Gemma / Luque Moreno, Verònica
Keywords: Screening Quality-of-life Prevalence Population Pediatric gastroenterology Long-term health Health-care services General practice Follow-up Diagnosis Consequences Coeliac disease Children Adolescents
Abstract: The worldwide prevalence of asymptomatic coeliac disease (CD) is increasing, which is in part due to the routine screening of children with risk factors. Both symptomatic and asymptomatic patients with CD are at risk of long-term complications. The objective of this study was to compare the clinical characteristics of asymptomatic and symptomatic children at the time of CD diagnosis. A case-control study was conducted using data from a cohort of 4838 CD patients recruited from 73 centers across Spain between 2011 and 2017. A total of 468 asymptomatic patients (cases) were selected and matched by age and sex with 468 symptomatic patients (controls). Clinical data, including any reported symptoms, as well as serologic, genetic, and histopathologic data were collected. No significant differences were found between the two groups in most clinical variables, nor in the degree of intestinal lesion. However, the asymptomatic patients were taller (height z-score -0.12 (1.06) vs. -0.45 (1.19), p < 0.001) and were less likely to have anti transglutaminase IgA antibodies >= 10 times the upper normal limit (66.2% vs. 758.4%, p = 0.002). Among the 37.1% of asymptomatic patients who were not screened for CD due to the absence of risk factors, only 34% were truly asymptomatic, while the remaining 66% reported non-specific CD-related symptoms. Therefore, expanding CD screening to any child who undergoes a blood test could reduce the burden of care for some children, as many of those considered asymptomatic reported non-specific CD-related symptoms.
Thematic Areas: Zootecnia / recursos pesqueiros Saúde coletiva Química Psicología Planejamento urbano e regional / demografia Nutrition and dietetics Nutrition & dietetics Nutrição Medicina veterinaria Medicina iii Medicina ii Medicina i Interdisciplinar Food science Farmacia Engenharias iv Engenharias ii Enfermagem Educação física Economia Ciências biológicas iii Ciências biológicas ii Ciências biológicas i Ciências agrárias i Ciência de alimentos Biotecnología
licence for use: https://creativecommons.org/licenses/by/3.0/es/
Author's mail: veronica.luque@urv.cat gemma.castillejo@urv.cat
Author identifier: 0000-0003-2615-8175
Record's date: 2024-08-03
Papper version: info:eu-repo/semantics/publishedVersion
Link to the original source: https://www.mdpi.com/2072-6643/15/5/1267
Licence document URL: https://repositori.urv.cat/ca/proteccio-de-dades/
Papper original source: Nutrients. 15 (5):
APA: Castillejo, G; Ochoa-Sangrador, C; Perez-Solis, D; Cilleruelo, ML; Donat, E; Garcia-Burriel, JI; Sanchez-Valverde, F; Garcia-Calatayud, S; Eizaguirre, (2023). Coeliac Disease Case-Control Study: Has the Time Come to Explore beyond Patients at Risk?. Nutrients, 15(5), -. DOI: 10.3390/nu15051267
Article's DOI: 10.3390/nu15051267
Entity: Universitat Rovira i Virgili
Journal publication year: 2023
Publication Type: Journal Publications