Increase from low to moderate, but not high, caffeinated coffee consumption is associated with favorable changes in body fat

Author, as appears in the article.: Henn, Matthias; Babio, Nancy; Romaguera, Dora; Vazquez-Ruiz, Zenaida; Konieczna, Jadwiga; Vioque, Jesus; Torres-Collado, Laura; Razquin, Cristina; Buil-Cosiales, Pilar; Fito, Montserrat; Schroder, Helmut; Hu, Frank B; Abete, Itziar; Zulet, M Angeles; Fernandez-Villa, Tania; Martin, Vicente; Estruch, Ramon; Vidal, Josep; Paz-Graniel, Indira; Martinez, J Alfredo; Salas-Salvado, Jordi; Martinez-Gonzalez, Miguel A; Ruiz-Canela, Miguel

Department: Bioquímica i Biotecnologia

URV's Author/s: Babio Sánchez, Nancy Elvira / Paz Graniel, Indira del Socorro / Salas Salvadó, Jorge

Keywords: Visceral fat; Risk factors; Prospective studies; Predimed-plus trial; Obesity; Metabolic syndrome; Male; Humans; Female; Dxa; Coffee consumption; Coffee; Caffeine; Adiposity distribution; Adipose tissue; visceral fat; predimed-plus trial; dxa; caffeine; adiposity distribution

Abstract: Background & aims: Higher consumption of coffee and caffeine has been linked to less weight gain and lower body mass index in prospective cohort studies. The aim of the study was to longitudinally assess the association of changes in coffee and caffeine intake with changes in fat tissue, in particular, visceral adipose tissue (VAT) using dual x-ray absorptiometry (DXA). Methods: In the setting of a large, randomized trial of Mediterranean diet and physical activity intervention, we evaluated 1483 participants with metabolic syndrome (MetS). Repeated measurements of coffee consumption from validated food frequency questionnaires (FFQ) and DXA measurements of adipose tissue were collected at baseline, 6 months, 12 months and 3 years of follow-up. DXA-derived measurements of total and regional adipose tissue expressed as % of total body weight were transformed into sex-specific z-scores. Linear multilevel mixed-effect models were used to investigate the relationship between changes in coffee consumption and corresponding concurrent changes in fat tissue during a 3-year follow-up. Results: After adjustment for intervention group, and other potential confounders, an increase in caffeinated coffee consumption from no or infrequent consumption (≤3 cups/month) to moderate consumption (1–7 cups/week) was associated with reductions in total body fat (Δ z-score: −0.06; 95% CI: −0.11 to −0.02), trunk fat (Δ z-score: −0.07; 95% CI: −0.12 to −0.02), and VAT (Δ z-score: −0.07; 95% CI: −0.13 to −0.01). Neither changes from no or infrequent consumption to high levels of caffeinated coffee consumption (>1 cup/day) nor any changes in decaffeinated coffee consumption showed significant associations with changes in DXA measures. Conclusions: Moderate changes in the consumption of caffeinated coffee, but not changes to high consumption, were associated with reductions in total body fat, trunk fat and VAT in a Mediterranean cohort with MetS. Decaffeinated coffee was not linked to adiposity indicators. Moderate consumption of caffeinated coffee may be part of a weight management strategy. Trial registration: The trial was registered at the International Standard Randomized Controlled Trial (ISRCTN: http://www.isrctn.com/ISRCTN89898870) with number 89898870 and registration date of 24 July 2014, retrospectively registered.

Thematic Areas: Saúde coletiva; Química; Odontología; Nutrition and dietetics; Nutrition & dietetics; Nutrição; Medicina iii; Medicina ii; Medicina i; Interdisciplinar; General medicine; Farmacia; Engenharias iv; Enfermagem; Educação física; Critical care and intensive care medicine; Ciências biológicas iii; Ciências biológicas ii; Ciências biológicas i; Ciência de alimentos; Biotecnología

licence for use: https://creativecommons.org/licenses/by/3.0/es/

Author's mail: indiradelsocorro.paz@urv.cat; indiradelsocorro.paz@urv.cat; jordi.salas@urv.cat; nancy.babio@urv.cat

Record's date: 2025-02-19

Paper version: info:eu-repo/semantics/publishedVersion

Link to the original source: https://www.clinicalnutritionjournal.com/article/S0261-5614(23)00033-X/fulltext

Licence document URL: https://repositori.urv.cat/ca/proteccio-de-dades/

Paper original source: Clinical Nutrition. 42 (4): 477-485

APA: Henn, Matthias; Babio, Nancy; Romaguera, Dora; Vazquez-Ruiz, Zenaida; Konieczna, Jadwiga; Vioque, Jesus; Torres-Collado, Laura; Razquin, Cristina; Bui (2023). Increase from low to moderate, but not high, caffeinated coffee consumption is associated with favorable changes in body fat. Clinical Nutrition, 42(4), 477-485. DOI: 10.1016/j.clnu.2023.02.004

Article's DOI: 10.1016/j.clnu.2023.02.004

Entity: Universitat Rovira i Virgili

Journal publication year: 2023

Publication Type: Journal Publications