Author, as appears in the article.: Iglesias-Vázquez, L; Voltas, N; Hernández-Martínez, C; Canals, J; Coronel, P; Gimeno, M; Basora, J; Arija, V
Department: Psicologia Ciències Mèdiques Bàsiques
URV's Author/s: Arija Val, Maria Victoria / Basora Gallisa, Josep / Canals Sans, Josefa / Hernandez Martinez, Carmen / Iglesias Vazquez, Lucia / Voltas Moreso, Núria
Keywords: Term-follow-up pregnancy hemoglobin deficiency brain-development behavior anemia alters age
Abstract: Introduction: The effectiveness of prenatal iron supplementation improves maternal hematological outcomes, but little research has focused on child outcomes. The objective of this study was to assess whether prenatal iron supplementation adjusted to maternal needs improves children's cognitive functioning. Methods: The analyses included a subsample of nonanemic pregnant women recruited in early pregnancy and their children aged 4 years (n=295). Data were collected between 2013 and 2017 in Tarragona (Spain). On the basis of hemoglobin levels before the 12th gestational week, women receive different iron doses: 80 vs 40 mg/d if hemoglobin is 110–130 g/L and 20 vs 40 mg/d if hemoglobin >130 g/L. Children's cognitive functioning was assessed using the Wechsler Preschool and Primary Scale of Intelligence-IV and Developmental Neuropsychological Assessment-II tests. The analyses were carried out in 2022 after the completion of the study. Multivariate regression models were performed for assessing the association between different doses of prenatal iron supplementation and children's cognitive functioning. Results: Taking 80 mg/d of iron was positively associated with all the scales of the Wechsler Preschool and Primary Scale of Intelligence-IV and Neuropsychological Assessment-II when mothers had initial serum ferritin <15 µg/L, but it was negatively associated with Verbal Comprehension Index, Working Memory Index, Processing Speed Index, and Vocabulary Acquisition Index from Wechsler Preschool and Primary Scale of Intelligence-IV and verbal fluency index from Neuropsychological Assessment-II when mothers showed initial serum ferritin >65 µg/L. In the other group, taking 20 mg/d of iron was positively associated with Working Memory Index, Intelligence Quotient, verbal fluency, and emotion recognition indices when women had initial serum ferritin >65 µg/L. Conclusions: Prenatal iron supplementation adjusted to the maternal hemoglobin levels and baseline iron stores improves cognitive functioning in children aged 4 years.
Thematic Areas: Saúde coletiva Public, environmental & occupational health Public health, environmental and occupational health Psicología Planejamento urbano e regional / demografia Medicine, general & internal Medicina ii Medicina i General medicine Epidemiology Enfermagem Educação física
licence for use: https://creativecommons.org/licenses/by/3.0/es/
Author's mail: josep.basora@urv.cat nuria.voltas@urv.cat victoria.arija@urv.cat josefa.canals@urv.cat josep.basora@urv.cat carmen.hernandez@urv.cat lucia.iglesias@urv.cat
Author identifier: 0000-0001-8855-0282 0000-0002-1758-0975 0000-0002-6209-9558 0000-0001-6328-8679 0000-0001-7131-4144
Record's date: 2024-01-13
Papper version: info:eu-repo/semantics/publishedVersion
Link to the original source: https://www.sciencedirect.com/science/article/pii/S0749379723000703
Licence document URL: http://repositori.urv.cat/ca/proteccio-de-dades/
Papper original source: American Journal Of Preventive Medicine. 65 (3): 395-405
APA: Iglesias-Vázquez, L; Voltas, N; Hernández-Martínez, C; Canals, J; Coronel, P; Gimeno, M; Basora, J; Arija, V (2023). Importance of Maternal Iron Status on the Improvement of Cognitive Function in Children After Prenatal Iron Supplementation. American Journal Of Preventive Medicine, 65(3), 395-405. DOI: 10.1016/j.amepre.2023.02.006
Article's DOI: 10.1016/j.amepre.2023.02.006
Entity: Universitat Rovira i Virgili
Journal publication year: 2023
Publication Type: Journal Publications
Repositori URV