Dietary intake of polychlorinated dibenzo-p-dioxins and furans, adiposity and obesity status.

Author, as appears in the article.: Khoury, Nadine; Angeles Martinez, Maria; Paz-Graniel, Indira; Angel Martinez-Gonzalez, Miguel; Corella, Dolores; Castaner, Olga; Alfredo Martinez, J; Alonso-Gomez, Angel M; Warnberg, Julia; Vioque, Jesus; Romaguera, Dora; Lopez-Miranda, Jose; Estruch, Ramon; Tinahones, Francisco J; Lapetra, Jose; Lluis Serra-Majem, J; Bueno-Cavanillas, Aurora; Tur, Josep A; Cinza Sanjurjo, Sergio; Pinto, Xavier; Juan Gaforio, Jose; Matia-Martin, Pilar; Vidal, Josep; Vazquez, Clotilde; Daimiel, Lidia; Ros, Emilio; Sayon-Orea, Carmen; Sorli, Jose V; Perez-Vega, Karla-Alejandra; Garcia-Rios, Antonio; Gomez Bellvert, Nuria; Gomez-Gracia, Enrique; Zulet, M A; Chaplin, Alice; Casas, Rosa; Salcedo-Bellido, Inmaculada; Tojal-Sierra, Lucas; Bernal-Lopez, Maria-Rosa; Vazquez-Ruiz, Zenaida; Asensio, Eva M; Goday, Albert; Pena-Orihuela, Patricia J; Signes-Pastor, Antonio J; Garcia-Arellano, Ana; Fito, Montse; Babio, Nancy; Salas-Salvado, Jordi

Department: Bioquímica i Biotecnologia

URV's Author/s: Alkhoury, Nadine / Babio Sánchez, Nancy Elvira / Martínez Rodríguez, María Ángeles / Paz Graniel, Indira del Socorro / Salas Salvadó, Jorge

Keywords: Prospective studies; Polychlorinated dibenzodioxins; Polychlorinated dibenzo-p-furans (pcdd/f); Polychlorinated dibenzo-p-furans (pcdd; Polychlorinated biphenyls; Overweight; Obesity, abdominal; Obesity; Middle aged; Male; Humans; General-population; Furans; Female; Endocrine disrupting chemicals; Eating; Dioxins; Dibenzofurans, polychlorinated; Dibenzofurans; Cross-sectional studies; Adiposity; Abdominal obesity; polychlorobiphenyls; pcdd/fs; pcbs; obesity; metabolic syndrome; health; f); exposure; endocrine disrupting chemicals; biphenyls; adults; adiposity; adherence; abdominal obesity

Abstract: Introduction: The principal source of exposure to Polychlorinated dibenzo-p-dioxins and polychlorinated dibenzo-p-furans (PCDD/Fs) in humans comes from food intake. PCDD/Fs, are a family of potential endocrine disruptors and have been associated with different chronic diseases such as diabetes and hypertension. However, studies assessing the relationship between dietary exposure to PCDD/Fs and adiposity or obesity status in a middle-aged population are limited. Objective: To assess cross-sectionally and longitudinally the associations between estimated dietary intake (DI) of PCDD/Fs and body mass index (BMI), waist circumference, and the prevalence/incidence of obesity and abdominal obesity in a middle-aged population. Methods: In 5899 participants aged 55–75 years (48% women) living with overweight/obesity from the PREDIMED-plus cohort, PCDD/Fs DI was estimated using a 143-item validated food-frequency questionnaire, and the levels of food PCDD/F expressed as Toxic Equivalents (TEQ). Consequently, cross-sectional and prospective associations between baseline PCDD/Fs DI (in pgTEQ/week) and adiposity or obesity status were assessed at baseline and after 1-year follow-up using multivariable cox, logistic or linear regression models. Results: Compared to participants in the first PCDD/F DI tertile, those in the highest tertile presented a higher BMI (β-coefficient [confidence interval]) (0.43kg/m2 [0.22; 0.64]; P-trend <0.001), a higher waist circumference (1.11 cm [0.55; 1.66]; P-trend <0.001), and a higher prevalence of obesity and abdominal obesity (1.05 [1.01; 1.09] and 1.02 [1.00; 1.03]; P-trend = 0.09 and 0.027, respectively). In the prospective analysis, participants in the top PCDD/F DI baseline tertile showed an increase in waist circumference compared with those in the first tertile after 1-year of follow-up (β-coefficient 0.37 cm [0.06; 0.70]; P-trend = 0.015). Conclusion: Higher DI of PCDD/Fs was positively associated with adiposity parameters and obesity status at baseline and with changes in waist circumference after 1-year of follow-up in subjects living with overweight/obesity. Further large prospective studies using a different population with longer follow-up periods are warranted in the future to strengthen our results.

Thematic Areas: Zootecnia / recursos pesqueiros; Saúde coletiva; Química; Public, environmental & occupational health; Public health, environmental and occupational health; Psicología; Planejamento urbano e regional / demografia; Odontología; Medicina iii; Medicina ii; Medicina i; Materiais; Interdisciplinar; Geociências; General medicine; General environmental science; Farmacia; Environmental sciences; Environmental science (miscellaneous); Environmental science (all); Ensino; Engenharias iii; Engenharias ii; Engenharias i; Enfermagem; Educação física; Direito; Ciências biológicas iii; Ciências biológicas ii; Ciências biológicas i; Ciências ambientais; Ciências agrárias i; Ciência de alimentos; Biotecnología; Biodiversidade; Biochemistry; Astronomia / física

licence for use: https://creativecommons.org/licenses/by/3.0/es/

Author's mail: indiradelsocorro.paz@urv.cat; mangeles.martinez@urv.cat; nadine.khoury@estudiants.urv.cat; indiradelsocorro.paz@urv.cat; jordi.salas@urv.cat; nancy.babio@urv.cat

Record's date: 2025-01-28

Paper version: info:eu-repo/semantics/publishedVersion

Link to the original source: https://www.sciencedirect.com/science/article/pii/S0013935123004899?via%3Dihub

Licence document URL: https://repositori.urv.cat/ca/proteccio-de-dades/

Paper original source: Environmental Research. 227 115697-

APA: Khoury, Nadine; Angeles Martinez, Maria; Paz-Graniel, Indira; Angel Martinez-Gonzalez, Miguel; Corella, Dolores; Castaner, Olga; Alfredo Martinez, J; (2023). Dietary intake of polychlorinated dibenzo-p-dioxins and furans, adiposity and obesity status.. Environmental Research, 227(), 115697-. DOI: 10.1016/j.envres.2023.115697

Article's DOI: 10.1016/j.envres.2023.115697

Entity: Universitat Rovira i Virgili

Journal publication year: 2023

Publication Type: Journal Publications