SUCNR1 signaling in adipocytes controls energy metabolism by modulating circadian clock and leptin expression

Identifier:  imarina:9295186

Handle: https://hdl.handle.net/20.500.11797/imarina9295186

Authors:  Villanueva-Carmona, T; Cedó, L; Madeira, A; Ceperuelo-Mallafré, V; Rodríguez-Peña, MM; Núñez-Roa, C; Maymó-Masip, E; Repollés-de-Dalmau, M; Badia, J; Keiran, N; Mirasierra, M; Pimenta-Lopes, C; Sabadell-Basallote, J; Bosch, R; Caubet, L; Escolà-Gil, JC; Fernández-Real, JM; Vilarrasa, N; Ventura, F; Vallejo, M; Vendrell, J; Fernández-Veledo, S

Abstract:
Adipose tissue modulates energy homeostasis by secreting leptin, but little is known about the factors governing leptin production. We show that succinate, long perceived as a mediator of immune response and lipolysis, controls leptin expression via its receptor SUCNR1. Adipocyte-specific deletion of Sucnr1 influences metabolic health according to nutritional status. Adipocyte Sucnr1 deficiency impairs leptin response to feeding, whereas oral succinate mimics nutrient-related leptin dynamics via SUCNR1. SUCNR1 activation controls leptin expression via the circadian clock in an AMPK/JNK-C/EBPα-dependent manner. Although the anti-lipolytic role of SUCNR1 prevails in obesity, its function as a regulator of leptin signaling contributes to the metabolically favorable phenotype in adipocyte-specific Sucnr1 knockout mice under standard dietary conditions. Obesity-associated hyperleptinemia in humans is linked to SUCNR1 overexpression in adipocytes, which emerges as the major predictor of adipose tissue leptin expression. Our study establishes the succinate/SUCNR1 axis as a metabolite-sensing pathway mediating nutrient-related leptin dynamics to control whole-body homeostasis.Copyright © 2023 Elsevier Inc. All rights reserved.