Author, as appears in the article.: Marquès, M; Iftimie, S; Camps, J; Joven, J; Domingo, JL
Department: Ciències Mèdiques Bàsiques Medicina i Cirurgia
URV's Author/s: Camps Andreu, Jorge / Domingo Roig, José Luis / Iftimie Iftimie, Simona Mihaela / Joven Maried, Jorge / Marquès Bueno, Montserrat
Keywords: Toxic elements Serum samples Sars-cov-2 Essential elements Covid-19 patients toxic elements serum samples essential elements covid-19 patients
Abstract: Background: In recent months, the current COVID-19 pandemic has generated thousands of studies directly or indirectly related with this disease and/or the coronavirus SARS-CoV-2 causing the infection. On August 22, 2022, the database PUBMED included 287,639 publications containing the term COVID-19. However, in spite of the importance of trace elements in human health, including the immune system, data on the levels of metals/metalloids in COVID-19 patients is very limited. Methods: The concentrations of As, Cd, Cr, Cu, Hg, Fe, Mg, Mn, Pb, Se, V and Zn were determined by inductively coupled plasma-mass spectrometry (ICP-MS) in 126 serum samples of individuals infected with SARS-CoV-2, as well as in 88 samples of non-infected individuals. Participants were divided into four groups: i) individuals COVID-19 positive (COVID-19 +) with an asymptomatic infection course; ii) individuals suffering mild COVID-19; iii) individuals suffering severe COVID-19, and iv) individuals COVID-19 negative (COVID-19-) (control group). The occurrence of the analyzed metals/metalloids was evaluated along with the biochemical profile, including blood cell counts, lipids, proteins and crucial enzymes. Results: Serum levels of Mg, V, Cr, Cu, Cd, and Pb were higher in COVID-19 positive patients than those in the control group. Although no significant differences were observed between the different groups of patients, the concentrations of Cd, Pb, V and Zn showed a tendency to be higher in individuals with severe COVID-19 than in those showing mild symptoms or being asymptomatic. Arsenic and Hg were rarely detected, regardless if the subjects were infected by SARS-CoV-2, or not. The current results did not show significant differences in the levels of the rest of analyzed elements according to the severity of the disease (asymptomatic, mild and severe). Conclusions: In spite of the results here obtained, we highlight the need to reduce the exposure to Cd, Pb and V to minimize the potential adverse health outcomes after COVID-19 infection. On the other hand, although a protective role of essential elements was not found, Mg and Cu concentrations were higher in severe COVID-19 patients than in non-infected individuals.
Thematic Areas: Saúde coletiva Química Odontología Nutrição Molecular medicine Medicina veterinaria Medicina iii Medicina ii Medicina i Matemática / probabilidade e estatística Interdisciplinar Inorganic chemistry Farmacia Engenharias iv Engenharias ii Engenharias i Endocrinology & metabolism Ciências biológicas iii Ciências biológicas ii Ciências biológicas i Ciências ambientais Ciências agrárias i Ciência de alimentos Biotecnología Biodiversidade Biochemistry & molecular biology Biochemistry Astronomia / física
licence for use: https://creativecommons.org/licenses/by/3.0/es/
Author's mail: simonamihaela.iftime@urv.cat jorge.camps@urv.cat montserrat.marques@urv.cat jorge.joven@urv.cat joseluis.domingo@urv.cat
Author identifier: 0000-0003-0714-8414 0000-0002-3165-3640 0000-0001-6302-8578 0000-0003-2749-4541 0000-0001-6647-9470
Record's date: 2024-08-03
Papper version: info:eu-repo/semantics/publishedVersion
Link to the original source: https://www.sciencedirect.com/science/article/pii/S0946672X23000366?via%3Dihub
Licence document URL: https://repositori.urv.cat/ca/proteccio-de-dades/
Papper original source: Journal Of Trace Elements In Medicine And Biology. 78 127160-
APA: Marquès, M; Iftimie, S; Camps, J; Joven, J; Domingo, JL (2023). The concentrations of essential/toxic elements in serum of COVID-19 patients are not directly related to the severity of the disease. Journal Of Trace Elements In Medicine And Biology, 78(), 127160-. DOI: 10.1016/j.jtemb.2023.127160
Article's DOI: 10.1016/j.jtemb.2023.127160
Entity: Universitat Rovira i Virgili
Journal publication year: 2023
Publication Type: Journal Publications
Repositori URV