Articles producció científica> Medicina i Cirurgia

Fatty Acid Binding Proteins 3 and 4 Predict Both All-Cause and Cardiovascular Mortality in Subjects with Chronic Heart Failure and Type 2 Diabetes Mellitus

  • Identification data

    Identifier: imarina:9295582
  • Authors:

    Rodríguez-Calvo, R
    Granado-Casas, M
    de Oca, APM
    Julian, MT
    Domingo, M
    Codina, P
    Santiago-Vacas, E
    Cediel, G
    Julve, J
    Rossell, J
    Masana, L
    Mauricio, D
    Lupón, J
    Bayes-Genis, A
    Alonso, N
  • Others:

    Author, as appears in the article.: Rodríguez-Calvo, R; Granado-Casas, M; de Oca, APM; Julian, MT; Domingo, M; Codina, P; Santiago-Vacas, E; Cediel, G; Julve, J; Rossell, J; Masana, L; Mauricio, D; Lupón, J; Bayes-Genis, A; Alonso, N
    Department: Medicina i Cirurgia
    URV's Author/s: Masana Marín, Luis / Rodríguez Calvo, Ricardo
    Keywords: Rehospitalization Left-ventricular mass Fabp4 Fabp3 Diabetic patients Chronic heart failure Cardiovascular death All-cause death uric-acid rehospitalization recommendations myocardial steatosis infarction fabp4 echocardiography dysfunction disease diabetic patients chronic heart failure cardiovascular death association american-society all-cause death
    Abstract: Subjects with type 2 diabetes mellitus (T2D) are at increased risk for heart failure (HF). The cardiac-specific (FABP3) and adipose-tissue-specific (FABP4) types of the fatty acid binding proteins have been associated with both all-cause and cardiovascular (CV) mortality. The aim of this study was to explore the prognosis value of FABP3 and FABP4 in ambulatory subjects with chronic HF (CHF), with and without T2D. A prospective study involving 240 ambulatory CHF subjects was performed. Patients were followed-up for a mean of 5.78 ± 3.30 years and cause of death (if any) was recorded. Primary endpoints were defined as all-cause and CV death, and a composite endpoint that included CV death or hospitalization for HF was included as a secondary endpoint. Baseline serum samples were obtained and the serum FABP3 and FABP4 concentrations were assessed by sandwich enzyme-linked immunosorbent assay. Survival analysis was performed with multivariable Cox regressions, using Fine and Gray competing risks models when needed, to explore the prognostic value of FABP3 and FABP4 concentrations, adjusting for potential confounders. Type 2 diabetes mellitus was highly prevalent, accounting for 47.5% for total subjects with CHF. Subjects with T2D showed higher mortality rates (T2D: 69.30%; non-T2D: 50.79%, p = 0.004) and higher serum FABP3 (1829.3 (1104.9–3440.5) pg/mL vs. 1396.05 (820.3–2362.16) pg/mL, p = 0.007) and FABP4 (45.5 (27.6–79.8) ng/mL vs. 34.1 (24.09–55.3) ng/mL, p = 0.006) concentrations compared with non-T2D CHF subjects. In the whole study cohort, FABP3 was independently associated with all-cause death, and both FABP3 and FABP4 concentrations were associated with CV mortality. The predictive values of these two molecules for all-cause (FABP3: HR 1.25, 95% CI 1.09–1.44; p = 0.002. FABP4: HR 2.21, 95% CI 1.12–4.36; p = 0.023) and CV mortality (FABP3: HR 1.28, 95% CI 1.09–1.50; p = 0.002. FABP4: HR 4.19, 95% CI 2.21–7.95; p < 0.001) were only statistically significant in the subgroup of subjects with T2D. Notably, FABP4 (HR 2.07, 95% CI 1.11–3.87; p = 0.022), but not FABP3, also predicted the occurrence of the composite endpoint (death or hospitalization for HF) only in subjects with T2D. All these associations were not found in CHF subjects without T2D. Our findings support the usefulness of serum FABP3 and FABP4 concentrations as independent predictors for the occurrence of all-cause and CV mortality in ambulatory subjects with CHF with T2D.
    Thematic Areas: Química Physiology Molecular biology Medicina ii Medicina i Interdisciplinar Food science & technology Food science Farmacia Engenharias ii Clinical biochemistry Ciências biológicas ii Ciências biológicas i Ciências ambientais Ciências agrárias i Ciência de alimentos Chemistry, medicinal Cell biology Biotecnología Biodiversidade Biochemistry & molecular biology Biochemistry
    licence for use: https://creativecommons.org/licenses/by/3.0/es/
    Author's mail: ricardo.rodriguez@urv.cat luis.masana@urv.cat
    Author identifier: 0000-0002-0789-4954
    Record's date: 2024-01-13
    Papper version: info:eu-repo/semantics/publishedVersion
    Link to the original source: https://www.mdpi.com/2076-3921/12/3/645
    Licence document URL: http://repositori.urv.cat/ca/proteccio-de-dades/
    Papper original source: Antioxidants. 12 (3):
    APA: Rodríguez-Calvo, R; Granado-Casas, M; de Oca, APM; Julian, MT; Domingo, M; Codina, P; Santiago-Vacas, E; Cediel, G; Julve, J; Rossell, J; Masana, L; M (2023). Fatty Acid Binding Proteins 3 and 4 Predict Both All-Cause and Cardiovascular Mortality in Subjects with Chronic Heart Failure and Type 2 Diabetes Mellitus. Antioxidants, 12(3), -. DOI: 10.3390/antiox12030645
    Article's DOI: 10.3390/antiox12030645
    Entity: Universitat Rovira i Virgili
    Journal publication year: 2023
    Publication Type: Journal Publications
  • Keywords:

    Biochemistry,Biochemistry & Molecular Biology,Cell Biology,Chemistry, Medicinal,Clinical Biochemistry,Food Science,Food Science & Technology,Molecular Biology,Physiology
    Rehospitalization
    Left-ventricular mass
    Fabp4
    Fabp3
    Diabetic patients
    Chronic heart failure
    Cardiovascular death
    All-cause death
    uric-acid
    rehospitalization
    recommendations
    myocardial steatosis
    infarction
    fabp4
    echocardiography
    dysfunction
    disease
    diabetic patients
    chronic heart failure
    cardiovascular death
    association
    american-society
    all-cause death
    Química
    Physiology
    Molecular biology
    Medicina ii
    Medicina i
    Interdisciplinar
    Food science & technology
    Food science
    Farmacia
    Engenharias ii
    Clinical biochemistry
    Ciências biológicas ii
    Ciências biológicas i
    Ciências ambientais
    Ciências agrárias i
    Ciência de alimentos
    Chemistry, medicinal
    Cell biology
    Biotecnología
    Biodiversidade
    Biochemistry & molecular biology
    Biochemistry
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