Articles producció científica> Medicina i Cirurgia

Effects of infant feeding with goat milk formula or cow milk formula on atopic dermatitis: protocol of the randomised controlled Goat Infant Formula Feeding and Eczema (GIraFFE) trial

  • Identification data

    Identifier: imarina:9295695
    Authors:
    Ferry JMGalera-Martínez RCampoy CSáenz de Pipaón MJarocka-Cyrta EWalkowiak JRomańczuk BEscribano JGispert MGrattarola PGruszfeld DIglesia IGrote VDemmelmair HHandel UGallier SKoletzko B
    Abstract:
    INTRODUCTION: Atopic dermatitis (AD) is a chronic, inflammatory skin condition significantly affecting quality of life. A small randomised trial showed an approximately one-third lower incidence of AD in goat milk formula-fed compared with cow milk formula-fed infants. However, due to limited statistical power, AD incidence difference was not found to be significant. This study aims to explore a potential risk reduction of AD by feeding a formula based on whole goat milk (as a source of protein and fat) compared with a formula based on cow milk proteins and vegetable oils. METHODS AND ANALYSIS: This two-arm (1:1 allocation), parallel, randomised, double-blind, controlled nutritional trial shall enrol up to 2296 healthy term-born infants until 3 months of age, if parents choose to start formula feeding. Ten study centres in Spain and Poland are participating. Randomised infants receive investigational infant and follow-on formulas either based on whole goat milk or on cow milk until the age of 12 months. The goat milk formula has a whey:casein ratio of 20:80 and about 50% of the lipids are milk fat from whole goat milk, whereas the cow milk formula, used as control, has a whey:casein ratio of 60:40 and 100% of the lipids are from vegetable oils. The energy and nutrient levels in both goat and cow milk formulas are the same. The primary endpoint is the cumulative incidence of AD until the age of 12 months diagnosed by study personnel based on the UK Working Party Diagnostic Criteria. The secondary endpoints include reported AD diagnosis, measures of AD, blood and stool markers, child growth, sleep, nutrition and quality of life. Participating children are followed until the age of 5 years. ETHICS AND DISSEMINATION: Ethical approval was obtained from the ethical committees
  • Others:

    Author, as appears in the article.: Ferry JM; Galera-Martínez R; Campoy C; Sáenz de Pipaón M; Jarocka-Cyrta E; Walkowiak J; Romańczuk B; Escribano J; Gispert M; Grattarola P; Gruszfeld D; Iglesia I; Grote V; Demmelmair H; Handel U; Gallier S; Koletzko B
    Department: Medicina i Cirurgia
    URV's Author/s: Escribano Subías, Joaquín / Gispert Llauradó, Mariona
    Keywords: Party diagnostic-criteria Nutrition & Paediatric dermatology Immunology Eczema Dietetics validation severity scorad index questionnaire prevalence paediatric dermatology nutrition & dietetics life immunology growth clinical-trials allocation
    Abstract: INTRODUCTION: Atopic dermatitis (AD) is a chronic, inflammatory skin condition significantly affecting quality of life. A small randomised trial showed an approximately one-third lower incidence of AD in goat milk formula-fed compared with cow milk formula-fed infants. However, due to limited statistical power, AD incidence difference was not found to be significant. This study aims to explore a potential risk reduction of AD by feeding a formula based on whole goat milk (as a source of protein and fat) compared with a formula based on cow milk proteins and vegetable oils. METHODS AND ANALYSIS: This two-arm (1:1 allocation), parallel, randomised, double-blind, controlled nutritional trial shall enrol up to 2296 healthy term-born infants until 3 months of age, if parents choose to start formula feeding. Ten study centres in Spain and Poland are participating. Randomised infants receive investigational infant and follow-on formulas either based on whole goat milk or on cow milk until the age of 12 months. The goat milk formula has a whey:casein ratio of 20:80 and about 50% of the lipids are milk fat from whole goat milk, whereas the cow milk formula, used as control, has a whey:casein ratio of 60:40 and 100% of the lipids are from vegetable oils. The energy and nutrient levels in both goat and cow milk formulas are the same. The primary endpoint is the cumulative incidence of AD until the age of 12 months diagnosed by study personnel based on the UK Working Party Diagnostic Criteria. The secondary endpoints include reported AD diagnosis, measures of AD, blood and stool markers, child growth, sleep, nutrition and quality of life. Participating children are followed until the age of 5 years. ETHICS AND DISSEMINATION: Ethical approval was obtained from the ethical committees of all participating institutions. TRIAL REGISTRATION NUMBER: NCT04599946.
    Thematic Areas: Saúde coletiva Psicología Odontología Nutrição Medicine, general & internal Medicine (miscellaneous) Medicine (all) Medicina veterinaria Medicina iii Medicina ii Medicina i Interdisciplinar General medicine Farmacia Ensino Enfermagem Educação física Ciências biológicas iii Ciências biológicas ii Ciências biológicas i Ciências ambientais Ciência da computação Biotecnología
    licence for use: https://creativecommons.org/licenses/by/3.0/es/
    Author's mail: mariona.gispert@urv.cat joaquin.escribano@urv.cat
    Author identifier: 0000-0002-5041-459X
    Record's date: 2024-08-03
    Papper version: info:eu-repo/semantics/publishedVersion
    Link to the original source: https://bmjopen.bmj.com/content/13/4/e070533.long
    Licence document URL: https://repositori.urv.cat/ca/proteccio-de-dades/
    Papper original source: Bmj Open. 13 (4): e070533-
    APA: Ferry JM; Galera-Martínez R; Campoy C; Sáenz de Pipaón M; Jarocka-Cyrta E; Walkowiak J; Romańczuk B; Escribano J; Gispert M; Grattarola P; Gruszfeld D (2023). Effects of infant feeding with goat milk formula or cow milk formula on atopic dermatitis: protocol of the randomised controlled Goat Infant Formula Feeding and Eczema (GIraFFE) trial. Bmj Open, 13(4), e070533-. DOI: 10.1136/bmjopen-2022-070533
    Article's DOI: 10.1136/bmjopen-2022-070533
    Entity: Universitat Rovira i Virgili
    Journal publication year: 2023
    Publication Type: Journal Publications
  • Keywords:

    Medicine (Miscellaneous),Medicine, General & Internal
    Party diagnostic-criteria
    Nutrition & Paediatric dermatology
    Immunology
    Eczema
    Dietetics
    validation
    severity
    scorad index
    questionnaire
    prevalence
    paediatric dermatology
    nutrition & dietetics
    life
    immunology
    growth
    clinical-trials
    allocation
    Saúde coletiva
    Psicología
    Odontología
    Nutrição
    Medicine, general & internal
    Medicine (miscellaneous)
    Medicine (all)
    Medicina veterinaria
    Medicina iii
    Medicina ii
    Medicina i
    Interdisciplinar
    General medicine
    Farmacia
    Ensino
    Enfermagem
    Educação física
    Ciências biológicas iii
    Ciências biológicas ii
    Ciências biológicas i
    Ciências ambientais
    Ciência da computação
    Biotecnología
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