Articles producció científica> Bioquímica i Biotecnologia

Insights into oral microbiome and colorectal cancer – on the way of searching new perspectives

  • Identification data

    Identifier: imarina:9296474
    Authors:
    Kudra, AMuszynski, DSobocki, BKAtzeni, ACarbone, LKazmierczak-Siedlecka, KPolom, KKalinowski, L
    Abstract:
    Microbiome is a keystone polymicrobial community that coexist with human body in a beneficial relationship. These microorganisms enable the human body to maintain homeostasis and take part in mechanisms of defense against infection and in the absorption of nutrients. Even though microbiome is involved in physiologic processes that are beneficial to host health, it may also cause serious detrimental issues. Additionally, it has been proven that bacteria can migrate to other human body compartments and colonize them even although significant structural differences with the area of origin exist. Such migrations have been clearly observed when the causes of genesis and progression of colorectal cancer (CRC) have been investigated. It has been demonstrated that the oral microbiome is capable of penetrating into the large intestine and cause impairments leading to dysbiosis and stimulation of cancerogenic processes. The main actors of such events seem to be oral pathogenic bacteria belonging to the red and orange complex (regarding classification of bacteria in the context of periodontal diseases), such as Porphyromonas gingivalis and Fusobacterium nucleatum respectively, which are characterized by significant amount of cancerogenic virulence factors. Further examination of oral microbiome and its impact on CRC may be crucial on early detection of this disease and would allow its use as a precise non-invasive biomarker.
  • Others:

    Author, as appears in the article.: Kudra, A; Muszynski, D; Sobocki, BK; Atzeni, A; Carbone, L; Kazmierczak-Siedlecka, K; Polom, K; Kalinowski, L
    Department: Bioquímica i Biotecnologia
    URV's Author/s: Atzeni, Alessandro
    Keywords: bacterial virulence factors biofilm dysbiosis oral microbiome periodontitis porphyromonas-gingivalis Bacterial virulence factors Biofilm Colorectal cancer Fusobacterium-nucleatum Oral microbiome Periodontitis
    Abstract: Microbiome is a keystone polymicrobial community that coexist with human body in a beneficial relationship. These microorganisms enable the human body to maintain homeostasis and take part in mechanisms of defense against infection and in the absorption of nutrients. Even though microbiome is involved in physiologic processes that are beneficial to host health, it may also cause serious detrimental issues. Additionally, it has been proven that bacteria can migrate to other human body compartments and colonize them even although significant structural differences with the area of origin exist. Such migrations have been clearly observed when the causes of genesis and progression of colorectal cancer (CRC) have been investigated. It has been demonstrated that the oral microbiome is capable of penetrating into the large intestine and cause impairments leading to dysbiosis and stimulation of cancerogenic processes. The main actors of such events seem to be oral pathogenic bacteria belonging to the red and orange complex (regarding classification of bacteria in the context of periodontal diseases), such as Porphyromonas gingivalis and Fusobacterium nucleatum respectively, which are characterized by significant amount of cancerogenic virulence factors. Further examination of oral microbiome and its impact on CRC may be crucial on early detection of this disease and would allow its use as a precise non-invasive biomarker.
    Thematic Areas: Biodiversidade Biotecnología Ciências agrárias i Ciências biológicas i Ciências biológicas ii Ciências biológicas iii Ensino Farmacia Geociências Immunology Infectious diseases Interdisciplinar Medicina i Medicina ii Medicina iii Medicina veterinaria Medicine (miscellaneous) Microbiology Microbiology (medical) Odontología Química Saúde coletiva
    licence for use: https://creativecommons.org/licenses/by/3.0/es/
    Author's mail: alessandro.atzeni@urv.cat alessandro.atzeni@urv.cat
    Author identifier: 0000-0002-1804-8606 0000-0002-1804-8606
    Record's date: 2023-12-17
    Papper version: info:eu-repo/semantics/publishedVersion
    Link to the original source: https://www.frontiersin.org/journals/cellular-and-infection-microbiology/articles/10.3389/fcimb.2023.1159822/full
    Papper original source: Frontiers In Cellular And Infection Microbiology. 13
    APA: Kudra, A; Muszynski, D; Sobocki, BK; Atzeni, A; Carbone, L; Kazmierczak-Siedlecka, K; Polom, K; Kalinowski, L (2023). Insights into oral microbiome and colorectal cancer – on the way of searching new perspectives. Frontiers In Cellular And Infection Microbiology, 13(), -. DOI: 10.3389/fcimb.2023.1159822
    Licence document URL: https://repositori.urv.cat/ca/proteccio-de-dades/
    Article's DOI: 10.3389/fcimb.2023.1159822
    Entity: Universitat Rovira i Virgili
    Journal publication year: 2023
    Publication Type: Journal Publications
  • Keywords:

    Immunology,Infectious Diseases,Medicine (Miscellaneous),Microbiology,Microbiology (Medical)
    bacterial virulence factors
    biofilm
    dysbiosis
    oral microbiome
    periodontitis
    porphyromonas-gingivalis
    Bacterial virulence factors
    Biofilm
    Colorectal cancer
    Fusobacterium-nucleatum
    Oral microbiome
    Periodontitis
    Biodiversidade
    Biotecnología
    Ciências agrárias i
    Ciências biológicas i
    Ciências biológicas ii
    Ciências biológicas iii
    Ensino
    Farmacia
    Geociências
    Immunology
    Infectious diseases
    Interdisciplinar
    Medicina i
    Medicina ii
    Medicina iii
    Medicina veterinaria
    Medicine (miscellaneous)
    Microbiology
    Microbiology (medical)
    Odontología
    Química
    Saúde coletiva
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