Author, as appears in the article.: Rodriguez-Borjabad, Celia; Narveud, Ingunn; Christensen, Jacob Juel; Ibarretxe, Daiana; Andreychuk, Natalia; Girona, Josefa; Torvik, Kristin; Folkedal, Guro; Bogsrud, Martin P; Retterstol, Kjetil; Plana, Nuria; Masana, Luis; Holven, Kirsten B
Department: Medicina i Cirurgia; Ciències Mèdiques Bàsiques
URV's Author/s: Andreychuk Pasichna, Natalia / Girona Tell, Josefa / Ibarretxe Gerediaga, Daiana / Masana Marín, Luis / Plana Gil, Núria / Rodríguez Borjabad, Cèlia
Keywords: Phenotype; Nordic diet; Nmr lipid profile; Mediterranean diet; Lipoproteins; Hyperlipoproteinemia type ii; Humans; Familial hypercholesterolemia; Dietary fats; Diet, mediterranean; Cross-sectional studies; Coded food diary; Children; validation; prevention; nordic diet; nmr lipid profile; mediterranean diet; management; lipid profile; life; ldl cholesterol; frequency questionnaire; children; cardiovascular-disease; atherosclerosis
Abstract: Background and aims: Both Nordic and Mediterranean diets are considered healthy despite notable regional differences. Although these dietary patterns may lower cardiovascular risk, it is unclear if they improve the lipoprotein phenotype in children with familial hypercholesterolemia (FH). The aim is to determine the impact of Nordic and Mediterranean diets on the advanced lipoprotein profile in children with heterozygous FH (HeFH). Methods: This was a cross-sectional study performed in children with FH recruited from the Lipid Clinics at Sant Joan University Hospital in Reus (Spain) and Oslo University Hospital (Norway). Two-hundred fifty-six children (mean age 10 y/o; 48% girls): 85 Spanish and 29 Norwegian FH children, and 142 non-FH healthy controls (119 from Spain and 23 from Norway) were included in the study. A pathogenic FH-associated genetic variant was present in 81% of Spanish children with FH and all Norwegian children with FH. An 1H NMR based advanced lipoprotein test (Nightingale®) providing information on the particle number, size and lipid composition of 14 lipoprotein subclasses was performed and correlated to the dietary components. Results: Levels of LDL-C, HDL-C and triglycerides were not significantly different between the Nordic and Mediterranean FH groups. Spanish children with FH had more LDL particles, mainly of the large and medium LDL subclasses, than Norwegian FH children. Spanish FH children also had more HDL particles, mainly medium and small, than Norwegian FH children. The mean LDL size of Spanish FH children was larger, while the HDL size was smaller than that of the Norwegian FH children. The HDL particle number and size were the main determinants of differences between the two groups. In Norwegian children with FH, dietary total fat and MUFAs showed a significant correlation with all apolipoprotein B-containing lipoproteins and LDL size, whereas there was no correlation to SFA. A weaker association pattern was observed in the Spanish children. Conclusions: The lipoprotein profiles of Spanish and Norwegian children showed differences when studied by 1H NMR. These differences were in part associated with differences in dietary patterns.
Thematic Areas: Saúde coletiva; Psicología; Peripheral vascular disease; Odontología; Nutrição; Medicina iii; Medicina ii; Medicina i; Interdisciplinar; General medicine; Farmacia; Engenharias ii; Enfermagem; Educação física; Ciências biológicas iii; Ciências biológicas ii; Ciências biológicas i; Ciência de alimentos; Ciência da computação; Cardiology and cardiovascular medicine; Cardiac & cardiovascular systems; Biotecnología; Antropologia / arqueologia
licence for use: https://creativecommons.org/licenses/by/3.0/es/
Author's mail: natalia.andreychuk@urv.cat; celia.rodriguez@urv.cat; daiana.ibarretxe@urv.cat; josefa.girona@urv.cat; celia.rodriguez@urv.cat; josefa.girona@urv.cat; luis.masana@urv.cat
Record's date: 2025-02-19
Paper version: info:eu-repo/semantics/publishedVersion
Link to the original source: https://www.sciencedirect.com/science/article/pii/S002191502300179X
Licence document URL: https://repositori.urv.cat/ca/proteccio-de-dades/
Paper original source: Atherosclerosis. 373 38-45
APA: Rodriguez-Borjabad, Celia; Narveud, Ingunn; Christensen, Jacob Juel; Ibarretxe, Daiana; Andreychuk, Natalia; Girona, Josefa; Torvik, Kristin; Folkedal (2023). Association between Nordic and Mediterranean diets with lipoprotein phenotype assessed by 1HNMR in children with familial hypercholesterolemia. Atherosclerosis, 373(), 38-45. DOI: 10.1016/j.atherosclerosis.2023.04.009
Article's DOI: 10.1016/j.atherosclerosis.2023.04.009
Entity: Universitat Rovira i Virgili
Journal publication year: 2023
Publication Type: Journal Publications
Repositori URV