Author, as appears in the article.: Parra, Sandra; Marsillach, Judit; Aragones, Gerard; Beltran, Raul; Montero, Manuel; Coll, Blai; Mackness, Bharti; Mackness, Michael; Alonso-Villaverde, Carlos; Joven, Jorge; Camps, Jordi;
Department: Bioquímica i Biotecnologia Medicina i Cirurgia
URV's Author/s: Aragonès Bargalló, Gerard / Beltrán Debón, Raúl Alejandro / Camps Andreu, Jorge / Joven Maried, Jorge / MARSILLACH LÓPEZ, JUDIT / Montero Jaime, Manuel Jesus / Parra Pérez, Sandra
Keywords: Serum Risk-factor Proteins Pon1 Polymorphisms Life-style High-density-lipoprotein Coronary-heart-disease
Abstract: Background. Oxidative stress is associated with human immunodeficiency virus (HIV) infection. Paraoxonase-1 (PON1) is an antioxidant enzyme that is bound to high-density lipoproteins (HDLs). We evaluated whether PON1 gene haplotypes influence the metabolic disturbances, presence of subclinical atherosclerosis, and virologic outcome associated with the infection.Methods. DNA from blood samples collected from 234 HIV-infected patients and 633 healthy control subjects had single-nucleotide polymorphisms of PON1(192), PON1(55), PON1(-162), PON1(-832), PON1(-909), PON1(-1076), and PON1(-1741) analyzed using the Iplex Gold MassArray method. Subsequently, the influence of these single-nucleotide polymorphisms on measured biochemical and clinical variables was assessed.Results. We observed significant differences in the haplotype distribution between the control subjects and the HIV-infected patients. Haplotype H10 (GTCCGTC) was more prevalent in the HIV-infected patients (6.41% vs 0.64%; P < .001), and haplotype H5 (GACCGTC) was less prevalent in HIV-infected patients (27.7% vs 42.9%; P = .001). In HIV-infected patients, haplotype H7 (AATTCCT) was associated with better CD4(+) cell count recovery, higher levels of HDL cholesterol (P = .048) and apolipoprotein A-I (P = .019), lower levels of triglycerides (P = .004), and lower rates of subclinical arteriosclerosis (P < .001).Conclusions. PON1 haplotypes segregate with HIV infection, HDL metabolism, the presence of subclinical atherosclerosis, and CD4(+) cell recovery after treatment.
Thematic Areas: Zootecnia / recursos pesqueiros Saúde coletiva Odontología Microbiology Medicine (all) Medicina veterinaria Medicina iii Medicina ii Medicina i Materiais Interdisciplinar Infectious diseases Immunology and allergy Immunology General medicine Farmacia Engenharias iv Enfermagem Educação física Ciências biológicas iii Ciências biológicas ii Ciências biológicas i Biotecnología Biodiversidade
licence for use: https://creativecommons.org/licenses/by/3.0/es/
Author's mail: manueljesus.montero@urv.cat jorge.camps@urv.cat sandra.parra@urv.cat jorge.joven@urv.cat gerard.aragones@urv.cat raul.beltran@urv.cat
Author identifier: 0000-0002-3165-3640 0000-0001-9363-6574 0000-0003-2749-4541 0000-0001-9691-1906
Record's date: 2024-09-07
Papper version: info:eu-repo/semantics/submittedVersion
Licence document URL: https://repositori.urv.cat/ca/proteccio-de-dades/
Papper original source: Journal Of Infectious Diseases. 201 (4): 627-634
APA: Parra, Sandra; Marsillach, Judit; Aragones, Gerard; Beltran, Raul; Montero, Manuel; Coll, Blai; Mackness, Bharti; Mackness, Michael; Alonso-Villaverde (2010). Paraoxonase-1 Gene Haplotypes Are Associated with Metabolic Disturbances, Atherosclerosis, and Immunologic Outcome in HIV-Infected Patients. Journal Of Infectious Diseases, 201(4), 627-634. DOI: 10.1086/650312
Entity: Universitat Rovira i Virgili
Journal publication year: 2010
Publication Type: Journal Publications
Repositori URV