Articles producció científica> Medicina i Cirurgia

Gender determines the actions of adiponectin multimers on fetal growth and adiposity

  • Identification data

    Identifier: imarina:9298516
    Authors:
    Simon-Muela, InmaculadaNaf, SilviaBallesteros, MonicaVendrell, JoanCeperuelo-Mallafre, Victoriade la Flor, MiriamMegia, Ana
    Abstract:
    OBJECTIVE: We sought to analyze the role of cord blood adiponectin and its multimeric forms in neonatal adiposity and fetal growth velocity (FGV) during the third trimester of pregnancy according to fetal gender.STUDY DESIGN: This was a prospective analytical observational study conducted at the Diabetes and Pregnancy Unit, University Hospital Joan XXIII, Tarragona, Spain. In all, 96 healthy pregnant women were included in the early third trimester and were followed up until delivery. Maternal blood was obtained upon recruitment, and cord blood was obtained at delivery. Serial fetal ultrasounds were performed during the third trimester to assess FGV. Skinfolds were measured after birth to assess neonatal adiposity. Adiponectin multimers were determined in maternal and cord blood.RESULTS: In female neonates, adiposity and FGV in the late third trimester were correlated positively with cord blood insulin (r = 0.343, P = .015 and r = 0.430, P = .002, respectively) and maternal pregravid body mass index (r = 597, P < .001 and r = 0.428, P = .002, respectively), and negatively with maternal high-molecular-weight (HMW)/total adiponectin ratio (r = -0.269, P = .035 and r = -0.387, P = .005, respectively), but in the stepwise multiple regression model, the main determinants were cord blood insulin, pregravid body mass index, and cord blood HMW adiponectin. Otherwise, in male neonates, adiposity and fetal growth were correlated with cord blood low-molecular-weight adiponectin (r = 0.486, P = .003 and r = 0.394, P = .020, respectively), and it was this multimeric form that emerged as an independent determinant in the stepwise regression model.CONCLUSION: Adiponectin seems to determine fetal growth and adipose tissue accretion, and low molecular weight is more specifically implica
  • Others:

    Author, as appears in the article.: Simon-Muela, Inmaculada; Naf, Silvia; Ballesteros, Monica; Vendrell, Joan; Ceperuelo-Mallafre, Victoria; de la Flor, Miriam; Megia, Ana;
    Department: Medicina i Cirurgia
    URV's Author/s: Ballesteros Pérez, Monica / Ceperuelo Mallafré, Maria Victoria / De la Flor López, Miriam José / Megía Colet, Ana / Naf Cortés, Silvia Daniela / Simón Muela, María Inmaculada / Vendrell Ortega, Juan José
    Keywords: Pregnancies Neonatal adiposity Maternal serum adiponectin Leptin Intrauterine growth Glucose Fetal growth Diabetes-mellitus Cord blood Body-fat Birth-weight Age Adiponectin
    Abstract: OBJECTIVE: We sought to analyze the role of cord blood adiponectin and its multimeric forms in neonatal adiposity and fetal growth velocity (FGV) during the third trimester of pregnancy according to fetal gender.STUDY DESIGN: This was a prospective analytical observational study conducted at the Diabetes and Pregnancy Unit, University Hospital Joan XXIII, Tarragona, Spain. In all, 96 healthy pregnant women were included in the early third trimester and were followed up until delivery. Maternal blood was obtained upon recruitment, and cord blood was obtained at delivery. Serial fetal ultrasounds were performed during the third trimester to assess FGV. Skinfolds were measured after birth to assess neonatal adiposity. Adiponectin multimers were determined in maternal and cord blood.RESULTS: In female neonates, adiposity and FGV in the late third trimester were correlated positively with cord blood insulin (r = 0.343, P = .015 and r = 0.430, P = .002, respectively) and maternal pregravid body mass index (r = 597, P < .001 and r = 0.428, P = .002, respectively), and negatively with maternal high-molecular-weight (HMW)/total adiponectin ratio (r = -0.269, P = .035 and r = -0.387, P = .005, respectively), but in the stepwise multiple regression model, the main determinants were cord blood insulin, pregravid body mass index, and cord blood HMW adiponectin. Otherwise, in male neonates, adiposity and fetal growth were correlated with cord blood low-molecular-weight adiponectin (r = 0.486, P = .003 and r = 0.394, P = .020, respectively), and it was this multimeric form that emerged as an independent determinant in the stepwise regression model.CONCLUSION: Adiponectin seems to determine fetal growth and adipose tissue accretion, and low molecular weight is more specifically implicated in males, whereas the HMW isoform may be more important in females.
    Thematic Areas: Saúde coletiva Odontología Obstetrics and gynecology Obstetrics & gynecology Medicina iii Medicina ii Medicina i Interdisciplinar General medicine Farmacia Engenharias iv Ciências biológicas ii Ciências biológicas i Biotecnología Biodiversidade
    licence for use: https://creativecommons.org/licenses/by/3.0/es/
    Author's mail: monica.ballesteros@urv.cat miriamjose.delaflor@urv.cat silviadaniela.naf@urv.cat victoria.ceperuelo@urv.cat juanjose.vendrell@urv.cat ana.megia@urv.cat
    Author identifier: 0000-0002-4460-9761 0000-0002-6994-6115 0000-0002-5101-9452
    Record's date: 2024-01-27
    Papper version: info:eu-repo/semantics/acceptedVersion
    Link to the original source: https://www.sciencedirect.com/science/article/abs/pii/S0002937813002408
    Papper original source: American Journal Of Obstetrics And Gynecology. 208 (6):
    APA: Simon-Muela, Inmaculada; Naf, Silvia; Ballesteros, Monica; Vendrell, Joan; Ceperuelo-Mallafre, Victoria; de la Flor, Miriam; Megia, Ana; (2013). Gender determines the actions of adiponectin multimers on fetal growth and adiposity. American Journal Of Obstetrics And Gynecology, 208(6), -. DOI: 10.1016/j.ajog.2013.02.045
    Licence document URL: https://repositori.urv.cat/ca/proteccio-de-dades/
    Article's DOI: 10.1016/j.ajog.2013.02.045
    Entity: Universitat Rovira i Virgili
    Journal publication year: 2013
    Publication Type: Journal Publications
  • Keywords:

    Obstetrics & Gynecology,Obstetrics and Gynecology
    Pregnancies
    Neonatal adiposity
    Maternal serum adiponectin
    Leptin
    Intrauterine growth
    Glucose
    Fetal growth
    Diabetes-mellitus
    Cord blood
    Body-fat
    Birth-weight
    Age
    Adiponectin
    Saúde coletiva
    Odontología
    Obstetrics and gynecology
    Obstetrics & gynecology
    Medicina iii
    Medicina ii
    Medicina i
    Interdisciplinar
    General medicine
    Farmacia
    Engenharias iv
    Ciências biológicas ii
    Ciências biológicas i
    Biotecnología
    Biodiversidade
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