Articles producció científica> Bioquímica i Biotecnologia

Lipoprotein Particle Profiles Associated with Telomere Length and Telomerase Complex Components

  • Identification data

    Identifier: imarina:9321807
    Authors:
    Novau-Ferre, NilRojas, MelinaGutierrez-Tordera, LaiaArcelin, PierreFolch, JaumePapandreou, ChristopherBullo, Monica
    Abstract:
    Telomere length (TL) is a well-known marker of age-related diseases. Oxidative stress and inflammation increase the rate of telomere shortening, triggering cellular senescence. Although lipoproteins could have anti-inflammatory and proinflammatory functional properties, the relationship between lipoprotein particles with TL and telomerase activity-related genes has not been investigated much. In this study, we assessed the associations of lipoprotein subfractions with telomere length, TERT, and WRAP53 expression in a total of 54 pre-diabetic subjects from the EPIRDEM study. We regressed TL, TERT, and WRAP53 on 12 lipoprotein subclasses, employing a Gaussian linear regression method with Lasso penalty to determine a lipoprotein profile associated with telomere-related parameters. The covariates included age, sex, body mass index (BMI), dyslipidemia, statin consumption, and physical activity leisure time. We identified a lipoprotein profile composed of four lipoprotein subfractions associated with TL (Pearson r = 0.347, p-value = 0.010), two lipoprotein subfractions associated with TERT expression (Pearson r = 0.316, p-value = 0.020), and five lipoprotein subfractions associated with WRAP53 expression (Pearson r = 0.379, p-value =0.005). After adjusting for known confounding factors, most lipoprotein profiles maintained the association with TL, TERT, and WRAP53. Overall, medium and small-sized HDL particles were associated with shorter telomeres and lower expression of TERT and WRAP53. Large HDL particles were associated with longer telomere and lower expression of WRAP53, but not with TERT. Our results suggest that the lipoprotein profiles are associated with telomere length, TERT, and WRAP53 expression and should be considered when assessing the risk of chronic diseases
  • Others:

    Author, as appears in the article.: Novau-Ferre, Nil; Rojas, Melina; Gutierrez-Tordera, Laia; Arcelin, Pierre; Folch, Jaume; Papandreou, Christopher; Bullo, Monica
    Department: Bioquímica i Biotecnologia
    URV's Author/s: Bulló Bonet, Mònica / Folch Lopez, Jaume / GUTIERREZ TORDERA, LAIA / Novau Ferré, Nil / Rojas Criollo, Melina Isabella
    Keywords: Wrap53 Tert Telomere shortening Telomere length Telomere Telomerase complex components Telomerase Oxidative stress Lipoprotein subclasses Humans Hdl-cholesterol Cellular senescence wrap53 tert telomere length telomerase complex components risk population men hypertension disease
    Abstract: Telomere length (TL) is a well-known marker of age-related diseases. Oxidative stress and inflammation increase the rate of telomere shortening, triggering cellular senescence. Although lipoproteins could have anti-inflammatory and proinflammatory functional properties, the relationship between lipoprotein particles with TL and telomerase activity-related genes has not been investigated much. In this study, we assessed the associations of lipoprotein subfractions with telomere length, TERT, and WRAP53 expression in a total of 54 pre-diabetic subjects from the EPIRDEM study. We regressed TL, TERT, and WRAP53 on 12 lipoprotein subclasses, employing a Gaussian linear regression method with Lasso penalty to determine a lipoprotein profile associated with telomere-related parameters. The covariates included age, sex, body mass index (BMI), dyslipidemia, statin consumption, and physical activity leisure time. We identified a lipoprotein profile composed of four lipoprotein subfractions associated with TL (Pearson r = 0.347, p-value = 0.010), two lipoprotein subfractions associated with TERT expression (Pearson r = 0.316, p-value = 0.020), and five lipoprotein subfractions associated with WRAP53 expression (Pearson r = 0.379, p-value =0.005). After adjusting for known confounding factors, most lipoprotein profiles maintained the association with TL, TERT, and WRAP53. Overall, medium and small-sized HDL particles were associated with shorter telomeres and lower expression of TERT and WRAP53. Large HDL particles were associated with longer telomere and lower expression of WRAP53, but not with TERT. Our results suggest that the lipoprotein profiles are associated with telomere length, TERT, and WRAP53 expression and should be considered when assessing the risk of chronic diseases.
    Thematic Areas: Zootecnia / recursos pesqueiros Saúde coletiva Química Psicología Planejamento urbano e regional / demografia Nutrition and dietetics Nutrition & dietetics Nutrição Medicina veterinaria Medicina iii Medicina ii Medicina i Interdisciplinar Food science Farmacia Engenharias iv Engenharias ii Enfermagem Educação física Economia Ciências biológicas iii Ciências biológicas ii Ciências biológicas i Ciências agrárias i Ciência de alimentos Biotecnología
    licence for use: https://creativecommons.org/licenses/by/3.0/es/
    Author's mail: nil.novau@urv.cat melina.rojas@estudiants.urv.cat laia.gutierrez@urv.cat monica.bullo@urv.cat jaume.folch@urv.cat
    Author identifier: 0000-0002-0218-7046 0000-0002-5051-8858
    Record's date: 2024-10-12
    Papper version: info:eu-repo/semantics/publishedVersion
    Link to the original source: https://www.mdpi.com/2072-6643/15/11/2624
    Licence document URL: https://repositori.urv.cat/ca/proteccio-de-dades/
    Papper original source: Nutrients. 15 (11): 2624-
    APA: Novau-Ferre, Nil; Rojas, Melina; Gutierrez-Tordera, Laia; Arcelin, Pierre; Folch, Jaume; Papandreou, Christopher; Bullo, Monica (2023). Lipoprotein Particle Profiles Associated with Telomere Length and Telomerase Complex Components. Nutrients, 15(11), 2624-. DOI: 10.3390/nu15112624
    Article's DOI: 10.3390/nu15112624
    Entity: Universitat Rovira i Virgili
    Journal publication year: 2023
    Publication Type: Journal Publications
  • Keywords:

    Food Science,Nutrition & Dietetics,Nutrition and Dietetics
    Wrap53
    Tert
    Telomere shortening
    Telomere length
    Telomere
    Telomerase complex components
    Telomerase
    Oxidative stress
    Lipoprotein subclasses
    Humans
    Hdl-cholesterol
    Cellular senescence
    wrap53
    tert
    telomere length
    telomerase complex components
    risk
    population
    men
    hypertension
    disease
    Zootecnia / recursos pesqueiros
    Saúde coletiva
    Química
    Psicología
    Planejamento urbano e regional / demografia
    Nutrition and dietetics
    Nutrition & dietetics
    Nutrição
    Medicina veterinaria
    Medicina iii
    Medicina ii
    Medicina i
    Interdisciplinar
    Food science
    Farmacia
    Engenharias iv
    Engenharias ii
    Enfermagem
    Educação física
    Economia
    Ciências biológicas iii
    Ciências biológicas ii
    Ciências biológicas i
    Ciências agrárias i
    Ciência de alimentos
    Biotecnología
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