Articles producció científica> Bioquímica i Biotecnologia

Sweet treats before sleep disrupt the clock system and increase metabolic risk markers in healthy rats

  • Identification data

    Identifier: imarina:9321814
  • Authors:

    Soliz-Rueda, JR
    López-Fernández-Sobrino, R
    Schellekens, H
    Torres-Fuentes, C
    Arola, L
    Bravo, FI
    Muguerza, B
  • Others:

    Author, as appears in the article.: Soliz-Rueda, JR; López-Fernández-Sobrino, R; Schellekens, H; Torres-Fuentes, C; Arola, L; Bravo, FI; Muguerza, B
    Department: Bioquímica i Biotecnologia
    URV's Author/s: Arola Ferrer, Luis Maria / Bravo Vázquez, Francisca Isabel / Muguerza Marquínez, Maria Begoña / Soliz Rueda, Jorge Ricardo / Torres Fuentes, Cristina
    Keywords: Zeitgebers Snacking Metabolism Energy balance Circadian-rhythms Circadian rhythm Chrononutrition zeitgebers time snacking pattern pathophysiology metabolism mechanisms glucocorticoid-receptor food-intake energy balance circadian rhythm
    Abstract: Aim: Biological rhythms are endogenously generated natural cycles that act as pacemakers of different physiological mechanisms and homeostasis in the organism, and whose disruption increases metabolic risk. The circadian rhythm is not only reset by light but it is also regulated by behavioral cues such as timing of food intake. This study investigates whether the chronic consumption of a sweet treat before sleeping can disrupt diurnal rhythmicity and metabolism in healthy rats. Methods: For this, 32 Fischer rats were administered daily a low dose of sugar (160 mg/kg, equivalent to 2.5 g in humans) as a sweet treat at 8:00 a.m. or 8:00 p.m. (ZT0 and ZT12, respectively) for 4 weeks. To elucidate diurnal rhythmicity of clock gene expression and metabolic parameters, animals were sacrificed at different times, including 1, 7, 13, and 19 h after the last sugar dose (ZT1, ZT7, ZT13, and ZT19). Results: Increased body weight gain and higher cardiometabolic risk were observed when sweet treat was administered at the beginning of the resting period. Moreover, central clock and food intake signaling genes varied depending on snack time. Specifically, the hypothalamic expression of Nampt, Bmal1, Rev-erbα, and Cart showed prominent changes in their diurnal expression pattern, highlighting that sweet treat before bedtime disrupts hypothalamic control of energy homeostasis. Conclusions: These results show that central clock genes and metabolic effects following a low dose of sugar are strongly time-dependent, causing higher circadian metabolic disruption when it is consumed at the beginning of the resting period, that is, with the late-night snack.
    Thematic Areas: Zootecnia / recursos pesqueiros Psicología Physiology Nutrição Medicina veterinaria Medicina ii Medicina i Interdisciplinar General medicine Farmacia Engenharias iv Enfermagem Educação física Ciências biológicas iii Ciências biológicas ii Ciências biológicas i Ciências ambientais Ciência de alimentos Biodiversidade
    licence for use: https://creativecommons.org/licenses/by/3.0/es/
    Author's mail: franciscaisabel.bravo@urv.cat jorgericardo.soliz@urv.cat lluis.arola@urv.cat begona.muguerza@urv.cat cristina.torres@urv.cat
    Author identifier: 0000-0002-6468-3088 0000-0003-2767-1974 0000-0001-7384-8588 0000-0002-2917-6910
    Record's date: 2024-07-20
    Papper version: info:eu-repo/semantics/publishedVersion
    Link to the original source: https://onlinelibrary.wiley.com/doi/full/10.1111/apha.14005
    Licence document URL: http://repositori.urv.cat/ca/proteccio-de-dades/
    Papper original source: Acta Physiologica. 239 (3):
    APA: Soliz-Rueda, JR; López-Fernández-Sobrino, R; Schellekens, H; Torres-Fuentes, C; Arola, L; Bravo, FI; Muguerza, B (2023). Sweet treats before sleep disrupt the clock system and increase metabolic risk markers in healthy rats. Acta Physiologica, 239(3), -. DOI: 10.1111/apha.14005
    Article's DOI: 10.1111/apha.14005
    Entity: Universitat Rovira i Virgili
    Journal publication year: 2023
    Publication Type: Journal Publications
  • Keywords:

    Physiology
    Zeitgebers
    Snacking
    Metabolism
    Energy balance
    Circadian-rhythms
    Circadian rhythm
    Chrononutrition
    zeitgebers
    time
    snacking
    pattern
    pathophysiology
    metabolism
    mechanisms
    glucocorticoid-receptor
    food-intake
    energy balance
    circadian rhythm
    Zootecnia / recursos pesqueiros
    Psicología
    Physiology
    Nutrição
    Medicina veterinaria
    Medicina ii
    Medicina i
    Interdisciplinar
    General medicine
    Farmacia
    Engenharias iv
    Enfermagem
    Educação física
    Ciências biológicas iii
    Ciências biológicas ii
    Ciências biológicas i
    Ciências ambientais
    Ciência de alimentos
    Biodiversidade
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