Author, as appears in the article.: Soliz-Rueda, JR; López-Fernández-Sobrino, R; Schellekens, H; Torres-Fuentes, C; Arola, L; Bravo, FI; Muguerza, B
Department: Bioquímica i Biotecnologia
URV's Author/s: Arola Ferrer, Luis Maria / Bravo Vázquez, Francisca Isabel / Muguerza Marquínez, Maria Begoña / Soliz Rueda, Jorge Ricardo / Torres Fuentes, Cristina
Keywords: Zeitgebers Snacking Metabolism Energy balance Circadian-rhythms Circadian rhythm Chrononutrition zeitgebers time snacking pattern pathophysiology metabolism mechanisms glucocorticoid-receptor food-intake energy balance circadian rhythm
Abstract: Aim: Biological rhythms are endogenously generated natural cycles that act as pacemakers of different physiological mechanisms and homeostasis in the organism, and whose disruption increases metabolic risk. The circadian rhythm is not only reset by light but it is also regulated by behavioral cues such as timing of food intake. This study investigates whether the chronic consumption of a sweet treat before sleeping can disrupt diurnal rhythmicity and metabolism in healthy rats. Methods: For this, 32 Fischer rats were administered daily a low dose of sugar (160 mg/kg, equivalent to 2.5 g in humans) as a sweet treat at 8:00 a.m. or 8:00 p.m. (ZT0 and ZT12, respectively) for 4 weeks. To elucidate diurnal rhythmicity of clock gene expression and metabolic parameters, animals were sacrificed at different times, including 1, 7, 13, and 19 h after the last sugar dose (ZT1, ZT7, ZT13, and ZT19). Results: Increased body weight gain and higher cardiometabolic risk were observed when sweet treat was administered at the beginning of the resting period. Moreover, central clock and food intake signaling genes varied depending on snack time. Specifically, the hypothalamic expression of Nampt, Bmal1, Rev-erbα, and Cart showed prominent changes in their diurnal expression pattern, highlighting that sweet treat before bedtime disrupts hypothalamic control of energy homeostasis. Conclusions: These results show that central clock genes and metabolic effects following a low dose of sugar are strongly time-dependent, causing higher circadian metabolic disruption when it is consumed at the beginning of the resting period, that is, with the late-night snack.
Thematic Areas: Zootecnia / recursos pesqueiros Psicología Physiology Nutrição Medicina veterinaria Medicina ii Medicina i Interdisciplinar General medicine Farmacia Engenharias iv Enfermagem Educação física Ciências biológicas iii Ciências biológicas ii Ciências biológicas i Ciências ambientais Ciência de alimentos Biodiversidade
licence for use: https://creativecommons.org/licenses/by/3.0/es/
Author's mail: franciscaisabel.bravo@urv.cat cristina.torres@urv.cat begona.muguerza@urv.cat lluis.arola@urv.cat jorgericardo.soliz@urv.cat
Author identifier: 0000-0002-6468-3088 0000-0002-2917-6910 0000-0001-7384-8588 0000-0003-2767-1974
Record's date: 2024-01-27
Papper version: info:eu-repo/semantics/publishedVersion
Link to the original source: https://onlinelibrary.wiley.com/doi/full/10.1111/apha.14005
Licence document URL: http://repositori.urv.cat/ca/proteccio-de-dades/
Papper original source: Acta Physiologica. 239 (3):
APA: Soliz-Rueda, JR; López-Fernández-Sobrino, R; Schellekens, H; Torres-Fuentes, C; Arola, L; Bravo, FI; Muguerza, B (2023). Sweet treats before sleep disrupt the clock system and increase metabolic risk markers in healthy rats. Acta Physiologica, 239(3), -. DOI: 10.1111/apha.14005
Article's DOI: 10.1111/apha.14005
Entity: Universitat Rovira i Virgili
Journal publication year: 2023
Publication Type: Journal Publications
Repositori URV