Author, as appears in the article.: Canales-Rodríguez EJ; Verdolini N; Alonso-Lana S; Torres ML; Panicalli F; Argila-Plaza I; Rodriguez-Cano E; Montoro I; Garcia-Ruiz B; Jimenez E; Varo C; Lluch A; del Mar Bonnin C; Maluf S; Pujol M; Guarner NJ; Sarró S; Vieta E; Vilella E; Salvador R; Pomarol-Clotet E
Department: Medicina i Cirurgia
URV's Author/s: Garcia Ruiz, Beatriz / MONTORO SALVATIERRA, IRENE / Vilella Cuadrada, Elisabet
Keywords: White-matter Tissue microstructure Spherical mean technique Diffusion tensor imaging Brain Bipolar disorder tissue microstructure spherical mean technique lithium i disorder diffusion tensor imaging brain
Abstract: Despite diffusion tensor imaging (DTI) evidence for widespread fractional anisotropy (FA) reductions in the brain white matter of patients with bipolar disorder, questions remain regarding the specificity and sensitivity of FA abnormalities as opposed to other diffusion metrics in the disorder. We conducted a whole-brain voxel-based multicompartment diffusion MRI study on 316 participants (i.e., 158 patients and 158 matched healthy controls) employing four diffusion metrics: the mean diffusivity (MD) and FA estimated from DTI, and the intra-axonal signal fraction (IASF) and microscopic axonal parallel diffusivity (Dpar) derived from the spherical mean technique. Our findings provide novel evidence about widespread abnormalities in other diffusion metrics in BD. An extensive overlap between the FA and IASF results suggests that the lower FA in patients may be caused by a reduced intra-axonal volume fraction or a higher macromolecular content in the intra-axonal water. We also found a diffuse alteration in MD involving white and grey matter tissue and more localised changes in Dpar. A Machine Learning analysis revealed that FA, followed by IASF, were the most helpful metric for the automatic diagnosis of BD patients, reaching an accuracy of 72%. Number of mood episodes, age of onset/duration of illness, psychotic symptoms, and current treatment with lithium, antipsychotics, antidepressants, and antiepileptics were all significantly associated with microstructure abnormalities. Lithium treatment was associated with less microstructure abnormality.© 2023 The Authors. Human Brain Mapping published by Wiley Periodicals LLC.
Thematic Areas: Radiology, nuclear medicine and imaging Radiology, nuclear medicine & medical imaging Radiological and ultrasound technology Psychology Psicología Neurosciences Neurology (clinical) Neurology Neuroimaging Medicina ii Medicina i Matemática / probabilidade e estatística Interdisciplinar Farmacia Engenharias iv Educação física Ciencias sociales Ciências biológicas ii Ciências biológicas i Ciências agrárias i Astronomia / física Anatomy
licence for use: https://creativecommons.org/licenses/by/3.0/es/
Author's mail: elisabet.vilella@urv.cat beatriz.garciar@estudiants.urv.cat
Author identifier: 0000-0002-1887-5919
Record's date: 2024-08-03
Papper version: info:eu-repo/semantics/publishedVersion
Link to the original source: https://onlinelibrary.wiley.com/doi/10.1002/hbm.26405
Licence document URL: https://repositori.urv.cat/ca/proteccio-de-dades/
Papper original source: Human Brain Mapping. 44 (12): 4605-4622
APA: Canales-Rodríguez EJ; Verdolini N; Alonso-Lana S; Torres ML; Panicalli F; Argila-Plaza I; Rodriguez-Cano E; Montoro I; Garcia-Ruiz B; Jimenez E; Varo (2023). Widespread intra-axonal signal fraction abnormalities in bipolar disorder from multicompartment diffusion MRI: Sensitivity to diagnosis, association with clinical features and pharmacologic treatment. Human Brain Mapping, 44(12), 4605-4622. DOI: 10.1002/hbm.26405
Article's DOI: 10.1002/hbm.26405
Entity: Universitat Rovira i Virgili
Journal publication year: 2023
Publication Type: Journal Publications