Author, as appears in the article.: Bosque, M; Margalef, R; Llaveria, A; Santafe, MM
Department: Ciències Mèdiques Bàsiques
URV's Author/s: Bosque Alberich, Marc / Margalef Pérez, Joan Ramon / Santafé Martínez, Manuel
Keywords: Spontaneous release of acetylcholine Psychological stress Neuromuscular junction Myofascial trigger points Mice In-vivo ultrasonic vocalizations spontaneous release of acetylcholine restriction rat psychological stress noise neuromuscular-junction neuromuscular junction muscle models mice habituation
Abstract: An increase in spontaneous neurotransmission may be related to myofascial pain. Sympathetic neurons innervate most of the neuromuscular junction sand are involved in the modulation of synaptic transmission. Therefore, a direct action of stress on acetylcholine release is expected. For this reason, this study aims to evaluate the relationship between stress and spontaneous neurotransmission. Five acute stressors (immobilization, forced swimming, food and water deprivation, social isolation and ultrasound) were tested in 6 weeks adult Swiss male mice. Subsequently, these types of stress were combined to generate a model of chronic stress. The study of ACh release was evaluated before and after the application of stress by intracellular recording of spontaneous neurotransmission (mEPPs). In each one of the stressors, an increase in the frequency of mEPPs was obtained immediately after treatment, which remained elevated for 5 days and thereafter returned to control values after a week. With chronic stress, a much higher increase in the frequency of mEPPs was obtained and it was maintained for 15 days. In summary, stress, both in its acute and chronic forms, increased spontaneous neurotransmission significantly. There is a possibility that chronic stress is related with the genesis or maintenance of myofascial pain.Copyright © 2023 The Authors. Published by Elsevier B.V. All rights reserved.
Thematic Areas: Zootecnia / recursos pesqueiros Saúde coletiva Química Psychology Psicología Odontología Nutrição Neurosciences Medicina veterinaria Medicina iii Medicina ii Medicina i Materiais Matemática / probabilidade e estatística Interdisciplinar Filosofia/teologia:subcomissão filosofia Farmacia Ensino Engenharias iv Engenharias ii Enfermagem Educação física Ciencias sociales Ciências biológicas iii Ciências biológicas ii Ciências biológicas i Ciências ambientais Ciência de alimentos Biotecnología Biodiversidade Behavioral sciences Behavioral neuroscience Administração pública e de empresas, ciências contábeis e turismo
licence for use: https://creativecommons.org/licenses/by/3.0/es/
Author's mail: joanramon.margalef@urv.cat manuel.santafe@urv.cat joanramon.margalef@urv.cat
Author identifier: 0000-0002-5462-5108
Record's date: 2024-01-14
Papper version: info:eu-repo/semantics/publishedVersion
Link to the original source: https://www.sciencedirect.com/science/article/pii/S0166432823002905?via%3Dihub
Licence document URL: http://repositori.urv.cat/ca/proteccio-de-dades/
Papper original source: Behavioural Brain Research. 452 114572-114572
APA: Bosque, M; Margalef, R; Llaveria, A; Santafe, MM (2023). Stress increases the spontaneous release of ACh and may be involved in the generation and maintenance of myofascial trigger points in mouse. Behavioural Brain Research, 452(), 114572-114572. DOI: 10.1016/j.bbr.2023.114572
Article's DOI: 10.1016/j.bbr.2023.114572
Entity: Universitat Rovira i Virgili
Journal publication year: 2023
Publication Type: Journal Publications
Repositori URV