Articles producció científica> Bioquímica i Biotecnologia

Administration time effect of dietary proanthocyanidins on the metabolome of Fischer 344 rats is sex- and diet-dependent

  • Identification data

    Identifier: imarina:9325573
    Authors:
    Arreaza-Gil, VeronicaPalacios-Jordan, HectorRomero, Maria del MarTorres-Fuentes, CristinaRodriguez, Miguel A ARemesar, XavierFernandez-Lopez, Jose-AntonioArola-Arnal, Anna
    Abstract:
    Proanthocyanidins (PAs) are one of the most commonly ingested polyphenols in the human diet, with a wide range of beneficial health effects. Remarkably, PAs have been reported to influence core and peripheral clock genes expression, and their effects may change in a time-of-day dependent manner. Therefore, the aim of this study was to investigate whether the capacity of PAs to modulate the metabolome is conditioned by the time-of-day in which these compounds are consumed in a diet- and sex-dependent manner. To do this, a grape seed proanthocyanidin extract (GSPE) was administered to female and male Fischer 344 rats at ZT0 (in the morning) and ZT12 (at night) and the GSPE administration time effect was evaluated on clock genes expression, melatonin hormone and serum metabolite levels in a healthy and obesogenic context. The results showed an administration time effect of GSPE on the metabolome in a sex and diet-dependent manner. Specifically, there was an effect on amino acid, lipid and cholate metabolite levels that correlated with the central clock genes expression. Therefore, this study shows a strong influence of sex and diet on the PAs effects on the metabolome, modulated in turn by the time-of-day.
  • Others:

    Author, as appears in the article.: Arreaza-Gil, Veronica; Palacios-Jordan, Hector; Romero, Maria del Mar; Torres-Fuentes, Cristina; Rodriguez, Miguel A A; Remesar, Xavier; Fernandez-Lopez, Jose-Antonio; Arola-Arnal, Anna
    Department: Bioquímica i Biotecnologia
    URV's Author/s: Arola Arnal, Anna / Arreaza Gil, Verónica / Rodríguez Merayo, María Araceli / Torres Fuentes, Cristina
    Keywords: Rats, wistar Rats, inbred f344 Rats Proanthocyanidins Metabolome Male Humans Grape seed extract Female Diet Circadian-rhythms Animals tryptophan-metabolism polyphenols plasma mechanisms healthy gut microbiota gender-differences expression clock
    Abstract: Proanthocyanidins (PAs) are one of the most commonly ingested polyphenols in the human diet, with a wide range of beneficial health effects. Remarkably, PAs have been reported to influence core and peripheral clock genes expression, and their effects may change in a time-of-day dependent manner. Therefore, the aim of this study was to investigate whether the capacity of PAs to modulate the metabolome is conditioned by the time-of-day in which these compounds are consumed in a diet- and sex-dependent manner. To do this, a grape seed proanthocyanidin extract (GSPE) was administered to female and male Fischer 344 rats at ZT0 (in the morning) and ZT12 (at night) and the GSPE administration time effect was evaluated on clock genes expression, melatonin hormone and serum metabolite levels in a healthy and obesogenic context. The results showed an administration time effect of GSPE on the metabolome in a sex and diet-dependent manner. Specifically, there was an effect on amino acid, lipid and cholate metabolite levels that correlated with the central clock genes expression. Therefore, this study shows a strong influence of sex and diet on the PAs effects on the metabolome, modulated in turn by the time-of-day.
    Thematic Areas: Zootecnia / recursos pesqueiros Saúde coletiva Química Odontología Nutrição Medicine (miscellaneous) Medicina veterinaria Medicina iii Medicina ii Medicina i Materiais Interdisciplinar Food science & technology Food science Farmacia Educação física Ciências biológicas ii Ciências biológicas i Ciências ambientais Ciências agrárias i Ciência de alimentos Biotecnología Biochemistry & molecular biology
    licence for use: https://creativecommons.org/licenses/by/3.0/es/
    Author's mail: veronica.arreaza@urv.cat veronica.arreaza@urv.cat veronica.arreaza@urv.cat anna.arola@urv.cat araceli.rodriguez@urv.cat araceli.rodriguez@urv.cat cristina.torres@urv.cat
    Author identifier: 0000-0002-8301-2095 0000-0002-8301-2095 0000-0002-8301-2095 0000-0001-6529-1345 0000-0002-9456-6528 0000-0002-9456-6528 0000-0002-2917-6910
    Record's date: 2024-10-12
    Papper version: info:eu-repo/semantics/publishedVersion
    Link to the original source: https://pubs.rsc.org/en/content/articlelanding/2023/fo/d3fo01551c
    Licence document URL: https://repositori.urv.cat/ca/proteccio-de-dades/
    Papper original source: Food & Function. 14 (15): 6941-6956
    APA: Arreaza-Gil, Veronica; Palacios-Jordan, Hector; Romero, Maria del Mar; Torres-Fuentes, Cristina; Rodriguez, Miguel A A; Remesar, Xavier; Fernandez-Lop (2023). Administration time effect of dietary proanthocyanidins on the metabolome of Fischer 344 rats is sex- and diet-dependent. Food & Function, 14(15), 6941-6956. DOI: 10.1039/d3fo01551c
    Article's DOI: 10.1039/d3fo01551c
    Entity: Universitat Rovira i Virgili
    Journal publication year: 2023
    Publication Type: Journal Publications
  • Keywords:

    Biochemistry & Molecular Biology,Food Science,Food Science & Technology,Medicine (Miscellaneous)
    Rats, wistar
    Rats, inbred f344
    Rats
    Proanthocyanidins
    Metabolome
    Male
    Humans
    Grape seed extract
    Female
    Diet
    Circadian-rhythms
    Animals
    tryptophan-metabolism
    polyphenols
    plasma
    mechanisms
    healthy
    gut microbiota
    gender-differences
    expression
    clock
    Zootecnia / recursos pesqueiros
    Saúde coletiva
    Química
    Odontología
    Nutrição
    Medicine (miscellaneous)
    Medicina veterinaria
    Medicina iii
    Medicina ii
    Medicina i
    Materiais
    Interdisciplinar
    Food science & technology
    Food science
    Farmacia
    Educação física
    Ciências biológicas ii
    Ciências biológicas i
    Ciências ambientais
    Ciências agrárias i
    Ciência de alimentos
    Biotecnología
    Biochemistry & molecular biology
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