Author, as appears in the article.: Moreno, I; Stojanovic-Pérez, A; Bulduk, B; Sánchez-Gistau, V; Algora, MJ; Ortega, L; Muntané, G; Vilella, E; Labad, J; Martorell, L
Department: Medicina i Cirurgia Infermeria
URV's Author/s: Bulduk, Bengisu Kevser / Martorell Bonet, Lourdes / Moreno Fernández, Irene / Muntané Medina, Gerard / Ortega Sanz, Laura / Sánchez Gistau, Vanessa / STOJANOVIC PÉREZ, ALEXANDER / Vilella Cuadrada, Elisabet
Keywords: Rs6265 Mrna expression Inflammation Il6 First-episode psychosis At-risk mental states
Abstract: The brain-derived neurotrophic factor (BDNF) single nucleotide polymorphism (SNP) rs6265C > T, Val66Met, affects BDNF secretion and has been related to inflammatory processes. Both the rs6265 and BDNF protein levels have been widely investigated in neuropsychiatric disorders with conflicting results. In the present study we examined BDNF mRNA expression in blood considering the SNP rs6265 and its relationship with inflammatory markers in the early stages of psychosis. The rs6265 genotype and blood BDNF mRNA levels were measured in 34 at-risk mental states (ARMS) individuals, 37 patients with first-episode psychosis (FEP) and 42 healthy controls (HCs) by quantitative PCR and reverse transcription (RT)-qPCR using validated TaqMan assays. We also obtained measures of interleukin-6 (IL6) mRNA levels, fibrinogen, neutrophil-to-lymphocyte ratio (NLR) and high-sensitivity C-reactive protein. We identified that BDNF mRNA levels were associated with the rs6265 genotype in an allele-dose-dependent manner, with low expression levels associated with the T allele (Met substitution). Thus, we controlled for the rs6265 genotype in all analyses. Blood BDNF mRNA levels differed between diagnostic groups: patients with FEP exhibited higher blood BDNF mRNA levels than ARMS individuals, and the lowest levels were observed in HC. In addition, we observed significant correlations between BDNF mRNA levels and inflammatory markers (IL6 mRNA levels and NLR), controlled by the rs6265 genotype, in ARMS and FEP groups. This exploratory study suggests that the rs6265 genotype is associated with differential blood mRNA expression of BDNF that increases with illness progression and correlated with inflammation in the early stages of psychosis.
Thematic Areas: Saúde coletiva Química Psychology Psychiatry and mental health Psychiatry Psicología Nutrição Medicina iii Medicina ii Medicina i Materiais Matemática / probabilidade e estatística Interdisciplinar Farmacia Engenharias iv Educação física Ciencias sociales Ciências biológicas iii Ciências biológicas ii Ciências biológicas i Biotecnología Biological psychiatry Arts and humanities (miscellaneous) Antropologia / arqueologia
licence for use: https://creativecommons.org/licenses/by/3.0/es/
Author's mail: gerard.muntane@urv.cat vanessa.sanchezg@urv.cat lourdes.martorell@urv.cat elisabet.vilella@urv.cat laura.ortega@urv.cat bengisukevser.bulduk@estudiants.urv.cat irene.moreno@estudiants.urv.cat
Author identifier: 0000-0003-4999-2197 0000-0002-1887-5919 0000-0003-2476-7700
Record's date: 2024-08-10
Papper version: info:eu-repo/semantics/acceptedVersion
Link to the original source: https://www.sciencedirect.com/science/article/abs/pii/S0022395623003424?via%3Dihub
Licence document URL: https://repositori.urv.cat/ca/proteccio-de-dades/
Papper original source: Journal Of Psychiatric Research. 164 440-446
APA: Moreno, I; Stojanovic-Pérez, A; Bulduk, B; Sánchez-Gistau, V; Algora, MJ; Ortega, L; Muntané, G; Vilella, E; Labad, J; Martorell, L (2023). High blood levels of brain-derived neurotrophic factor (BDNF) mRNA in early psychosis are associated with inflammatory markers. Journal Of Psychiatric Research, 164(), 440-446. DOI: 10.1016/j.jpsychires.2023.07.003
Article's DOI: 10.1016/j.jpsychires.2023.07.003
Entity: Universitat Rovira i Virgili
Journal publication year: 2023
Publication Type: Journal Publications
Repositori URV