Author, as appears in the article.: Sanchez-Gimenez, Raul; Peiro, Oscar M; Bonet, Gil; Carrasquer, Anna; Fragkiadakis, George A; Bullo, Monica; Papandreou, Christopher; Bardaji, Alfredo
Department: Medicina i Cirurgia Bioquímica i Biotecnologia
URV's Author/s: Bardají Ruiz, Alfredo / Bonet Pineda, Gil / Bulló Bonet, Mònica / Carrasquer Cucarella, Ana Maria / Peiró Ibáñez, Óscar Manuel / Sánchez Giménez, Raúl
Keywords: Tricarboxylic acid cycle Mortality Metabolomics Mass spectrometry Major adverse cardiovascular events Acute coronary syndrome
Abstract: Aims: To examine relationships of tricarboxylic acid (TCA) cycle metabolites with risk of cardiovascular events and mortality after acute coronary syndrome (ACS), and evaluate the mediating role of renal function in these associations. Methods: This is a prospective study performed among 309 ACS patients who were followed for a mean of 6.7 years. During this period 131 patients developed major adverse cardiovascular events (MACE), defined as the composite of myocardial infarction, hospitalization for heart failure, and all-cause mortality, and 90 deaths were recorded. Plasma concentrations of citrate, aconitate, isocitrate, succinate, malate, fumarate, α-ketoglutarate and d/l-2-hydroxyglutarate were quantified using LC-tandem MS. Multivariable Cox regression models were used to estimate hazard ratios, and a counterfactual-based mediation analysis was performed to test the mediating role of estimated glomerular filtration rate (eGFR). Results: After adjustment for traditional cardiovascular risk factors and medications, positive associations were found between isocitrate and MACE (HR per 1 SD, 1.25; 95% CI: 1.03, 1.50), and between aconitate, isocitrate, d/l-2-hydroxyglutarate and all-cause mortality (HR per 1 SD, 1.41; 95% CI: 1.07, 1.84; 1.58; 95% CI: 1.23, 2.02; 1.38; 95% CI: 1.14, 1.68). However, these associations were no longer significant after additional adjustment for eGFR. Mediation analyses demonstrated that eGFR is a strong mediator of these associations. Conclusion: These findings underscore the importance of TCA metabolites and renal function as conjunctive targets in the prevention of ACS complications.
Thematic Areas: Cardiology and cardiovascular medicine Cardiac & cardiovascular systems
licence for use: https://creativecommons.org/licenses/by/3.0/es/
Author's mail: gil.bonet@urv.cat oscarmanuel.peiro@urv.cat anamaria.carrasquer@urv.cat raul.sanchez@estudiants.urv.cat oscarmanuel.peiro@urv.cat anamaria.carrasquer@urv.cat monica.bullo@urv.cat alfredo.bardaji@urv.cat
Author identifier: 0000-0002-0218-7046 0000-0003-1900-6974
Record's date: 2024-10-12
Papper version: info:eu-repo/semantics/publishedVersion
Link to the original source: https://www.frontiersin.org/articles/10.3389/fcvm.2023.1157325/full
Licence document URL: https://repositori.urv.cat/ca/proteccio-de-dades/
Papper original source: Front Cardiovasc Med. 10 1157325-
APA: Sanchez-Gimenez, Raul; Peiro, Oscar M; Bonet, Gil; Carrasquer, Anna; Fragkiadakis, George A; Bullo, Monica; Papandreou, Christopher; Bardaji, Alfredo (2023). TCA cycle metabolites associated with adverse outcomes after acute coronary syndrome: mediating effect of renal function. Front Cardiovasc Med, 10(), 1157325-. DOI: 10.3389/fcvm.2023.1157325
Article's DOI: 10.3389/fcvm.2023.1157325
Entity: Universitat Rovira i Virgili
Journal publication year: 2023
Publication Type: Journal Publications