Articles producció científica> Psicologia

Metals linked with the most prevalent primary neurodegenerative dementias in the elderly: A narrative review

  • Identification data

    Identifier: imarina:9326310
  • Authors:

    Mateo, D
    Marques, M
    Torrente, M
  • Others:

    Author, as appears in the article.: Mateo, D; Marques, M; Torrente, M
    Department: Psicologia Ciències Mèdiques Bàsiques
    URV's Author/s: Marquès Bueno, Montserrat / Mateo García, David / Torrente Torné, Margarita
    Keywords: Mild cognitive impairment Metals Gut microbiota Dementia Cognition Ageing zinc selenium parkinsons-disease national-health metals iron deposition gut microbiota dementia copper cognition alzheimers-disease aluminum
    Abstract: The ageing population has been steadily increasing worldwide, leading to a higher risk of cognitive decline and dementia. Environmental toxicants, particularly metals, have been identified as modifiable risk factors for cognitive impairment. Continuous exposure to metals occurs mainly through dietary sources, with older adults being particularly vulnerable. However, imbalances in the gut microbiota, known as dysbiosis, have also been associated with dementia. A literature review was conducted to explore the potential role of metals in the development of cognitive decline and the most prevalent primary neurodegenerative dementias, as well as their interaction with the gut microbiota. High levels of iron (Fe) and copper (Cu) are associated with mild cognitive impairment (MCI) and Alzheimer's disease (AD), while low selenium (Se) levels are linked to poor cognitive status. Parkinson's disease dementia (PDD) is associated with elevated levels of iron (Fe), manganese (Mn), and zinc (Zn), but the role of copper (Cu) remains unclear. The relationship between metals and Lewy body dementia (LBD) requires further investigation. High aluminium (Al) exposure is associated with frontotemporal dementia (FTD), and elevated selenium (Se) levels may be linked to its onset. Challenges in comparing studies arise from the heterogeneity of metal analysis matrices and analytical techniques, as well as the limitations of small study cohorts. More research is needed to understand the influence of metals on cognition through the gut microbiota (GMB) and its potential relevance in the development of these diseases.
    Thematic Areas: Zootecnia / recursos pesqueiros Saúde coletiva Química Public, environmental & occupational health Public health, environmental and occupational health Psicología Planejamento urbano e regional / demografia Odontología Medicina iii Medicina ii Medicina i Materiais Interdisciplinar Geociências General medicine General environmental science Farmacia Environmental sciences Environmental science (miscellaneous) Environmental science (all) Ensino Engenharias iii Engenharias ii Engenharias i Enfermagem Educação física Direito Ciências biológicas iii Ciências biológicas ii Ciências biológicas i Ciências ambientais Ciências agrárias i Ciência de alimentos Biotecnología Biodiversidade Biochemistry Astronomia / física
    licence for use: https://creativecommons.org/licenses/by/3.0/es/
    Author's mail: montserrat.marques@urv.cat david.mateo@urv.cat margarita.torrente@urv.cat
    Author identifier: 0000-0001-6302-8578 0000-0002-8901-6345
    Record's date: 2024-07-20
    Papper version: info:eu-repo/semantics/publishedVersion
    Link to the original source: https://www.sciencedirect.com/science/article/pii/S0013935123015268?via%3Dihub
    Licence document URL: http://repositori.urv.cat/ca/proteccio-de-dades/
    Papper original source: Environmental Research. 236 (Pt 1): 116722-
    APA: Mateo, D; Marques, M; Torrente, M (2023). Metals linked with the most prevalent primary neurodegenerative dementias in the elderly: A narrative review. Environmental Research, 236(Pt 1), 116722-. DOI: 10.1016/j.envres.2023.116722
    Article's DOI: 10.1016/j.envres.2023.116722
    Entity: Universitat Rovira i Virgili
    Journal publication year: 2023
    Publication Type: Journal Publications
  • Keywords:

    Biochemistry,Environmental Science (Miscellaneous),Environmental Sciences,Public, Environmental & Occupational Health
    Mild cognitive impairment
    Metals
    Gut microbiota
    Dementia
    Cognition
    Ageing
    zinc
    selenium
    parkinsons-disease
    national-health
    metals
    iron deposition
    gut microbiota
    dementia
    copper
    cognition
    alzheimers-disease
    aluminum
    Zootecnia / recursos pesqueiros
    Saúde coletiva
    Química
    Public, environmental & occupational health
    Public health, environmental and occupational health
    Psicología
    Planejamento urbano e regional / demografia
    Odontología
    Medicina iii
    Medicina ii
    Medicina i
    Materiais
    Interdisciplinar
    Geociências
    General medicine
    General environmental science
    Farmacia
    Environmental sciences
    Environmental science (miscellaneous)
    Environmental science (all)
    Ensino
    Engenharias iii
    Engenharias ii
    Engenharias i
    Enfermagem
    Educação física
    Direito
    Ciências biológicas iii
    Ciências biológicas ii
    Ciências biológicas i
    Ciências ambientais
    Ciências agrárias i
    Ciência de alimentos
    Biotecnología
    Biodiversidade
    Biochemistry
    Astronomia / física
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