Articles producció científica> Medicina i Cirurgia

Clinical and Biomarker Profile Responses to Rehabilitation Treatment in Patients with Long COVID Characterized by Chronic Fatigue

  • Identification data

    Identifier: imarina:9326331
    Authors:
    Binetti, JessicaReal, MonicaRenzulli, MarcelaBertran, LaiaRiesco, DavidPerpinan, CarlesMohedano, AlbaSegundo, Rosa SanOrtiz, MartaPorras, Jose AntonioPineda, Daniela RosannaAuguet, Teresa
    Abstract:
    Long COVID (LC) syndrome is a complex multiorgan symptom that persists beyond >12 weeks after SARS-CoV-2 infection. The most frequently associated symptom is fatigue. Physical activity and exercise are recommended, although specific studies are lacking. The objectives of the present work are to analyze the impact of a supervised exercise program on the clinical evolution of LC with fatigue patients and to identify whether certain circulating biomarkers could predict the response to rehabilitation. The rehabilitation treatment response was analyzed in 14 women diagnosed with LC and fatigue, based on the changes in the 6 min walk test and Borg/Fatigue Impact scales. Patients who showed improvement in the meters walked were considered responders to the therapy. A total of 65% of patients responded to the exercise program, with an improvement in the meters walked and in oxygen saturation, with stability in the percentage of meters walked. Participants with obesity and those double-vaccinated against SARS-CoV-2 presented a lower degree of fatigue. LC patients presented a favorable response to a supervised exercise program. Differences in creatinine and protein levels were observed between rehabilitation therapy responders and nonresponders. A good state of protein nutrition was related to a better rehabilitation response. The results are promising regarding possible predictive biomarkers of rehabilitation response, such as creatinine.
  • Others:

    Author, as appears in the article.: Binetti, Jessica; Real, Monica; Renzulli, Marcela; Bertran, Laia; Riesco, David; Perpinan, Carles; Mohedano, Alba; Segundo, Rosa San; Ortiz, Marta; Porras, Jose Antonio; Pineda, Daniela Rosanna; Auguet, Teresa
    Department: Medicina i Cirurgia
    URV's Author/s: Auguet Quintillà, Maria Teresa / Bertran Ramos, Laia / Binetti, Jessica Angela / Perpiñan Auguet, Carles / Porras Ledantes, Jose Antonio / Real Álvarez, Monica Maria / Riesco Acevedo, David Gerardo / San Segundo Mozo, Rosa María
    Keywords: Sars-cov-2 Post-acute covid-19 syndrome Physical rehabilitation Long covid Humans Female Fatigue syndrome, chronic Creatinine Covid-19 Chronic fatigue Biomarkers sars-cov-2 physical rehabilitation chronic fatigue biomarkers
    Abstract: Long COVID (LC) syndrome is a complex multiorgan symptom that persists beyond >12 weeks after SARS-CoV-2 infection. The most frequently associated symptom is fatigue. Physical activity and exercise are recommended, although specific studies are lacking. The objectives of the present work are to analyze the impact of a supervised exercise program on the clinical evolution of LC with fatigue patients and to identify whether certain circulating biomarkers could predict the response to rehabilitation. The rehabilitation treatment response was analyzed in 14 women diagnosed with LC and fatigue, based on the changes in the 6 min walk test and Borg/Fatigue Impact scales. Patients who showed improvement in the meters walked were considered responders to the therapy. A total of 65% of patients responded to the exercise program, with an improvement in the meters walked and in oxygen saturation, with stability in the percentage of meters walked. Participants with obesity and those double-vaccinated against SARS-CoV-2 presented a lower degree of fatigue. LC patients presented a favorable response to a supervised exercise program. Differences in creatinine and protein levels were observed between rehabilitation therapy responders and nonresponders. A good state of protein nutrition was related to a better rehabilitation response. The results are promising regarding possible predictive biomarkers of rehabilitation response, such as creatinine.
    Thematic Areas: Zootecnia / recursos pesqueiros Virology Saúde coletiva Química Medicina veterinaria Medicina ii Medicina i Interdisciplinar Infectious diseases Ciências biológicas iii Ciências biológicas ii Ciências biológicas i Ciências ambientais Ciências agrárias i Biotecnología Biodiversidade
    licence for use: https://creativecommons.org/licenses/by/3.0/es/
    Author's mail: davidgerardo.riesco@urv.cat monicamaria.real@urv.cat jessicaangela.binetti@urv.cat carles.perpinan@urv.cat joseantonio.porras@urv.cat rosamaria.sansegundo@urv.cat jessicaangela.binetti@urv.cat carles.perpinan@urv.cat laia.bertranr@estudiants.urv.cat laia.bertranr@estudiants.urv.cat mariateresa.auguet@urv.cat
    Author identifier: 0000-0001-6418-1822 0000-0001-7420-2914 0000-0001-9052-1368 0000-0001-9052-1368 0000-0003-0396-6428
    Record's date: 2024-09-21
    Papper version: info:eu-repo/semantics/publishedVersion
    Link to the original source: https://www.mdpi.com/1999-4915/15/7/1452
    Licence document URL: https://repositori.urv.cat/ca/proteccio-de-dades/
    Papper original source: Viruses-Basel. 15 (7): 1452-
    APA: Binetti, Jessica; Real, Monica; Renzulli, Marcela; Bertran, Laia; Riesco, David; Perpinan, Carles; Mohedano, Alba; Segundo, Rosa San; Ortiz, Marta; Po (2023). Clinical and Biomarker Profile Responses to Rehabilitation Treatment in Patients with Long COVID Characterized by Chronic Fatigue. Viruses-Basel, 15(7), 1452-. DOI: 10.3390/v15071452
    Article's DOI: 10.3390/v15071452
    Entity: Universitat Rovira i Virgili
    Journal publication year: 2023
    Publication Type: Journal Publications
  • Keywords:

    Infectious Diseases,Virology
    Sars-cov-2
    Post-acute covid-19 syndrome
    Physical rehabilitation
    Long covid
    Humans
    Female
    Fatigue syndrome, chronic
    Creatinine
    Covid-19
    Chronic fatigue
    Biomarkers
    sars-cov-2
    physical rehabilitation
    chronic fatigue
    biomarkers
    Zootecnia / recursos pesqueiros
    Virology
    Saúde coletiva
    Química
    Medicina veterinaria
    Medicina ii
    Medicina i
    Interdisciplinar
    Infectious diseases
    Ciências biológicas iii
    Ciências biológicas ii
    Ciências biológicas i
    Ciências ambientais
    Ciências agrárias i
    Biotecnología
    Biodiversidade
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