Articles producció científica> Enginyeria Electrònica, Elèctrica i Automàtica

Tuning foreign body response with tailor-engineered nanoscale surface modifications: fundamentals to clinical applications

  • Identification data

    Identifier: imarina:9326346
    Authors:
    Yadav, TCBachhuka, A
    Abstract:
    Biomaterials are omnipresent in today's healthcare services and are employed in various applications, including implants, sensors, healthcare accessories, and drug delivery systems. Unfavorable host immunological responses frequently jeopardize the efficacy of biomaterials. As a result, surface modification has received much attention in controlling inflammatory responses since it helps camouflage the biomaterial from the host immune system, influencing the foreign body response (FBR) from protein adsorption to fibrous capsule formation. Surfaces with controlled nanotopography and chemistry, among other surface modification methodologies, have effectively altered the immune response to biomaterials. However, the field is still in its early stages, with only a few studies showing a synergistic effect of surface chemistry and nanotopography on inflammatory and wound healing pathways. Therefore, this review will concentrate on the individual and synergistic effects of surface chemistry and nanotopography on FBR modulation and the molecular processes known to modulate these responses. This review will also provide insights into crucial research gaps and advancements in various tactics for modulating FBR, opening new paths for future research. This will further aid in improving our understanding of the immune response to biomaterials, developing advanced surface modification techniques, designing immunomodulatory biomaterials, and translating discoveries into clinical applications.
  • Others:

    Author, as appears in the article.: Yadav, TC; Bachhuka, A
    Department: Enginyeria Electrònica, Elèctrica i Automàtica
    URV's Author/s: Bachhuka, Akash / Yadav, Tara Chand
    Keywords: Gold nanoparticles tio2 nanotubes resistant bacteria protein-adsorption nlrp3 inflammasome in-vitro giant-cells electrospun fibers biological responses adsorbed proteins
    Abstract: Biomaterials are omnipresent in today's healthcare services and are employed in various applications, including implants, sensors, healthcare accessories, and drug delivery systems. Unfavorable host immunological responses frequently jeopardize the efficacy of biomaterials. As a result, surface modification has received much attention in controlling inflammatory responses since it helps camouflage the biomaterial from the host immune system, influencing the foreign body response (FBR) from protein adsorption to fibrous capsule formation. Surfaces with controlled nanotopography and chemistry, among other surface modification methodologies, have effectively altered the immune response to biomaterials. However, the field is still in its early stages, with only a few studies showing a synergistic effect of surface chemistry and nanotopography on inflammatory and wound healing pathways. Therefore, this review will concentrate on the individual and synergistic effects of surface chemistry and nanotopography on FBR modulation and the molecular processes known to modulate these responses. This review will also provide insights into crucial research gaps and advancements in various tactics for modulating FBR, opening new paths for future research. This will further aid in improving our understanding of the immune response to biomaterials, developing advanced surface modification techniques, designing immunomodulatory biomaterials, and translating discoveries into clinical applications.
    Thematic Areas: Química Odontología Medicine (miscellaneous) Medicina ii Materials science, biomaterials Materials science (miscellaneous) Materials science (all) Materiais Interdisciplinar General medicine General materials science General chemistry Farmacia Engenharias iv Engenharias ii Ciências biológicas iii Ciências biológicas ii Ciências biológicas i Chemistry (miscellaneous) Chemistry (all) Biotecnología Biomedical engineering Astronomia / física
    licence for use: https://creativecommons.org/licenses/by/3.0/es/
    Author's mail: akash.bachhuka@urv.cat
    Author identifier: 0000-0003-1253-8126
    Record's date: 2024-08-03
    Papper version: info:eu-repo/semantics/publishedVersion
    Link to the original source: https://pubs.rsc.org/en/content/articlelanding/2023/tb/d3tb01040f
    Licence document URL: https://repositori.urv.cat/ca/proteccio-de-dades/
    Papper original source: Journal Of Materials Chemistry b. 11 (33): 7834-
    APA: Yadav, TC; Bachhuka, A (2023). Tuning foreign body response with tailor-engineered nanoscale surface modifications: fundamentals to clinical applications. Journal Of Materials Chemistry b, 11(33), 7834-. DOI: 10.1039/d3tb01040f
    Article's DOI: 10.1039/d3tb01040f
    Entity: Universitat Rovira i Virgili
    Journal publication year: 2023
    Publication Type: Journal Publications
  • Keywords:

    Biomedical Engineering,Chemistry (Miscellaneous),Materials Science (Miscellaneous),Materials Science, Biomaterials,Medicine (Miscellaneous)
    Gold nanoparticles
    tio2 nanotubes
    resistant bacteria
    protein-adsorption
    nlrp3 inflammasome
    in-vitro
    giant-cells
    electrospun fibers
    biological responses
    adsorbed proteins
    Química
    Odontología
    Medicine (miscellaneous)
    Medicina ii
    Materials science, biomaterials
    Materials science (miscellaneous)
    Materials science (all)
    Materiais
    Interdisciplinar
    General medicine
    General materials science
    General chemistry
    Farmacia
    Engenharias iv
    Engenharias ii
    Ciências biológicas iii
    Ciências biológicas ii
    Ciências biológicas i
    Chemistry (miscellaneous)
    Chemistry (all)
    Biotecnología
    Biomedical engineering
    Astronomia / física
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