Author, as appears in the article.: Mora, I; Pérez-Santamaria, A; Tortajada-Pérez, J; Vázquez-Manrique, RP; Arola, L; Puiggròs, F
Department: Bioquímica i Biotecnologia
URV's Author/s: Arola Ferrer, Luis Maria
Keywords: Structured lipids Pufa Polyunsaturated fatty-acids Physical decline Oxidative stress Omega-3 Nematode Healthspan Docosahexaenoic acid Daf-16/foxo Cognitive decline C. elegans Antioxidant Aging triglycerides structured lipids resistance pufa physical decline phospholipids oxidative stress omega-3 neurotransmission nematode modulation longevity life-span healthspan foxo elegans docosahexaenoic acid daf-16 cognitive decline caenorhabditis-elegans c antioxidant
Abstract: The human lifespan has increased over the past century; however, healthspans have not kept up with this trend, especially cognitive health. Among nutrients for brain function maintenance, long-chain omega-3 polyunsaturated fatty acids (ω-3 LCPUFA): DHA (docosahexaenoic acid) and EPA (eicosapentaenoic acid) must be highlighted, particularly structured forms of EPA and DHA which were developed to improve bioavailability and bioactivity in comparison with conventional ω-3 supplements. This study aims to elucidate the effect of a structured triglyceride form of DHA (DHA-TG) on the healthspan of aged C. elegans. Using a thrashing assay, the nematodes were monitored at 4, 8, and 12 days of adulthood, and DHA-TG improved its motility at every age without affecting lifespan. In addition, the treatment promoted antioxidant capacity by enhancing the activity and expression of SOD (superoxide dismutase) in the nematodes. Lastly, as the effect of DHA-TG was lost in the DAF-16 mutant strain, it might be hypothesized that the effects of DHA need DAF-16/FOXO as an intermediary. In brief, DHA-TG exerted a healthspan-promoting effect resulting in both enhanced physical fitness and increased antioxidant defense in aged C. elegans. For the first time, an improvement in locomotive function in aged wild-type nematodes is described following DHA-TG treatment.
Thematic Areas: Medicine (miscellaneous) Cell biology Biochemistry, genetics and molecular biology (miscellaneous) Biochemistry, genetics and molecular biology (all)
licence for use: https://creativecommons.org/licenses/by/3.0/es/
Author's mail: lluis.arola@urv.cat
Author identifier: 0000-0003-2767-1974
Record's date: 2024-08-03
Papper version: info:eu-repo/semantics/publishedVersion
Link to the original source: https://www.mdpi.com/2073-4409/12/15/1932
Licence document URL: https://repositori.urv.cat/ca/proteccio-de-dades/
Papper original source: Cells. 12 (15):
APA: Mora, I; Pérez-Santamaria, A; Tortajada-Pérez, J; Vázquez-Manrique, RP; Arola, L; Puiggròs, F (2023). Structured Docosahexaenoic Acid (DHA) Enhances Motility and Promotes the Antioxidant Capacity of Aged C. elegans. Cells, 12(15), -. DOI: 10.3390/cells12151932
Article's DOI: 10.3390/cells12151932
Entity: Universitat Rovira i Virgili
Journal publication year: 2023
Publication Type: Journal Publications
Repositori URV