Author, as appears in the article.: Atzeni, A; Nishi, SK; Babio, N; Belzer, C; Konstanti, P; Vioque, J; Corella, D; Castañer, O; Vidal, J; Moreno-Indias, I; Torres-Collado, L; Asensio, EM; Fitó, M; Gomez-Perez, AM; Arias, A; Ruiz-Canela, M; Hu, FB; Tinahones, FJ; Salas-Salvadó, J
Department: Bioquímica i Biotecnologia
URV's Author/s: Atzeni, Alessandro / Babio Sánchez, Nancy Elvira / Nishi, Stephanie Kimiko / Salas Salvadó, Jorge
Keywords: Mediterranean diet Mediterranean cohort Fecal microbiota Cardiovascular disease Carbohydrate quality validity population obesity mediterranean diet fecal microbiota cardiovascular disease association
Abstract: The impact of carbohydrate quality, measured by the carbohydrate quality index (CQI), on gut microbiota and health has been scarcely investigated. The aim of this study was to cross-sectionally and longitudinally explore the relationships between CQI, fecal microbiota, and cardiometabolic risk factors in an elderly Mediterranean population at high cardiovascular risk. At baseline and 1-year, CQI was assessed from food frequency questionnaires data, cardiometabolic risk factors were measured, and fecal microbiota profiled from 16S sequencing. Multivariable-adjusted linear regression models were fitted to assess the associations between tertiles of baseline CQI, fecal microbiota, and cardiometabolic risk factors at baseline, and between tertiles of 1-year change in CQI, 1-year change in fecal microbiota and cardiometabolic risk factors. Cross-sectionally, higher CQI was positively associated with Shannon alpha diversity index, and abundance of genera Faecalibacterium and Christensenellaceae R7 group, and negatively associated with the abundance of Odoribacter, and uncultured Rhodospirillales genera. Some of these genera were associated with higher glycated hemoglobin and lower body mass index. In addition, we observed a positive association between CQI, and some pathways related with the metabolism of butyrate precursors and plants-origin molecules. Longitudinally, 1-year improvement in CQI was associated with a concurrent increase in the abundance of genera Butyrivibrio. Increased abundance of this genera was associated with 1-year improvement in insulin status. These observations suggest that a better quality of carbohydrate intake is associated with improved metabolic health, and this improvement could be modulated by greater alpha diversity and abundance of specific genera linked to beneficial metabolic outcomes.
Thematic Areas: Microbiology (medical) Microbiology Medicina veterinaria Medicina i Infectious diseases Gastroenterology & hepatology Gastroenterology Ciências biológicas iii Ciências biológicas i Ciência de alimentos Biotecnología
licence for use: https://creativecommons.org/licenses/by/3.0/es/
Author's mail: stephanie.nishi@urv.cat alessandro.atzeni@urv.cat alessandro.atzeni@urv.cat jordi.salas@urv.cat nancy.babio@urv.cat
Author identifier: 0000-0002-1804-8606 0000-0002-1804-8606 0000-0003-2700-7459 0000-0003-3527-5277
Record's date: 2024-08-03
Papper version: info:eu-repo/semantics/publishedVersion
Link to the original source: https://www.tandfonline.com/doi/full/10.1080/19490976.2023.2246185
Licence document URL: https://repositori.urv.cat/ca/proteccio-de-dades/
Papper original source: Gut Microbes. 15 (2): 2246185-2246185
APA: Atzeni, A; Nishi, SK; Babio, N; Belzer, C; Konstanti, P; Vioque, J; Corella, D; Castañer, O; Vidal, J; Moreno-Indias, I; Torres-Collado, L; Asensio, E (2023). Carbohydrate quality, fecal microbiota and cardiometabolic health in older adults: a cohort study. Gut Microbes, 15(2), 2246185-2246185. DOI: 10.1080/19490976.2023.2246185
Article's DOI: 10.1080/19490976.2023.2246185
Entity: Universitat Rovira i Virgili
Journal publication year: 2023
Publication Type: Journal Publications
Repositori URV