Author, as appears in the article.: Cortés-Espinar, AJ; Ibarz-Blanch, N; Soliz-Rueda, JR; Bonafos, B; Feillet-Coudray, C; Casas, F; Bravo, FI; Calvo, E; Avila-Román, J; Mulero, M
Department: Bioquímica i Biotecnologia
URV's Author/s: Ávila Román, Francisco Javier / Bravo Vázquez, Francisca Isabel / Calvo Manso, Enrique / Cortés Espinar, Antonio Jesús / Ibarz Blanch, Néstor / Mulero Abellán, Miguel / Soliz Rueda, Jorge Ricardo
Keywords: Zeitgeber Proanthocyanidins Phenolic compounds Oxidative stress Liver Gspe Diurnal rhythms Circadian rhythms Chronotherapy Cafeteria diet zeitgeber translation proanthocyanidins phenolic compounds obesity modulate metabolic syndrome liver inflammation gspe glutathione gene-expression diurnal rhythms circadian-clock circadian rhythms chronotherapy cafeteria diet antioxidant
Abstract: Polyphenols play a key role in the modulation of circadian rhythms, while the cafeteria diet (CAF) is able to perturb the hepatic biological rhythm and induce important ROS production. Consequently, we aimed to elucidate whether grape seed proanthocyanidin extract (GSPE) administration recovers the CAF-induced hepatic antioxidant (AOX) misalignment and characterize the chronotherapeutic properties of GSPE. For this purpose, Fischer 344 rats were fed a standard diet (STD) or a CAF and concomitantly treated with GSPE at two time-points (ZT0 vs. ZT12). Animals were euthanized every 6 h and the diurnal rhythms of hepatic ROS-related biomarkers, hepatic metabolites, and AOX gene expression were examined. Interestingly, GSPE treatment was able to recover the diurnal rhythm lost due to the CAF. Moreover, GSPE treatment also increased the acrophase of Sod1, as well as bringing the peak closer to that of the STD group. GSPE also corrected some hepatic metabolites altered by the CAF. Importantly, the differences observed at ZT0 vs. ZT12 due to the time of GSPE administration highlight a chronotherapeutic profile on the proanthocyanin effect. Finally, GSPE could also reduce diet-induced hepatic oxidative stress not only by its ROS-scavenging properties but also by retraining the circadian rhythm of AOX enzymes.
Thematic Areas: Química Physiology Molecular biology Medicina ii Medicina i Interdisciplinar Food science & technology Food science Farmacia Engenharias ii Clinical biochemistry Ciências biológicas ii Ciências biológicas i Ciências ambientais Ciências agrárias i Ciência de alimentos Chemistry, medicinal Cell biology Biotecnología Biodiversidade Biochemistry & molecular biology Biochemistry
licence for use: https://creativecommons.org/licenses/by/3.0/es/
Author's mail: nestor.ibarz@urv.cat franciscojavier.avila@urv.cat franciscaisabel.bravo@urv.cat enrique.calvo@urv.cat miquel.mulero@urv.cat antoniojesus.cortes@urv.cat antoniojesus.cortes@urv.cat jorgericardo.soliz@urv.cat nestor.ibarz@urv.cat
Author identifier: 0000-0001-9766-8178 0000-0002-6468-3088
Record's date: 2024-04-27
Papper version: info:eu-repo/semantics/publishedVersion
Link to the original source: https://www.mdpi.com/2076-3921/12/8/1606
Licence document URL: http://repositori.urv.cat/ca/proteccio-de-dades/
Papper original source: Antioxidants. 12 (8):
APA: Cortés-Espinar, AJ; Ibarz-Blanch, N; Soliz-Rueda, JR; Bonafos, B; Feillet-Coudray, C; Casas, F; Bravo, FI; Calvo, E; Avila-Román, J; Mulero, M (2023). Rhythm and ROS: Hepatic Chronotherapeutic Features of Grape Seed Proanthocyanidin Extract Treatment in Cafeteria Diet-Fed Rats. Antioxidants, 12(8), -. DOI: 10.3390/antiox12081606
Article's DOI: 10.3390/antiox12081606
Entity: Universitat Rovira i Virgili
Journal publication year: 2023
Publication Type: Journal Publications
Repositori URV