Author, as appears in the article.: Rodulfo-Cárdenas, R; Ruiz-Sobremazas, D; Biosca-Brull, J; Cabré, M; Blanco, J; López-Granero, C; Sánchez-Santed, F; Colomina, MT
Department: Bioquímica i Biotecnologia Psicologia Ciències Mèdiques Bàsiques
URV's Author/s: Blanco Pérez, Jordi / Cabré Bargalló, Maria / Colomina Fosch, Maria Teresa
Keywords: Vulnerability Synaptic plasticity Postnatal exposure Persistent Particulate matter Oxytocin Neurodevelopmental disorders Mice Humans Developmental exposure Cognitive impairment Behavioral deficits Air-pollution
Abstract: Particulate matter (PM) is a major component of ambient air pollution (AAP), being widely associated with adverse health effects. Epidemiological and experimental studies point towards a clear implication of AAP on the development of central nervous system (CNS) diseases. In this sense, the period of most CNS susceptibility is early life, when the CNS is maturing. In humans the last trimester of gestation is crucial for brain maturation while in rodents, due to the shorter gestational period, the brain is still immature at birth, and early postnatal development plays a significant role. The present systematic review provides an updated overview and discusses the existing literature on the relationship between early exposure to PM and neurodevelopmental outcomes in experimental studies. We included 11 studies with postnatal exposure and 9 studies with both prenatal and postnatal exposure. Consistent results between studies suggest that PM exposure could alter normal develop-ment, triggering impairments in short-term memory, sociability, and impulsive-like behavior. This is also associated with alterations in synaptic plasticity and in the immune system. Interestingly, differences have been observed between sexes, although not all studies included females. Furthermore, the developmental window of exposure seems to be crucial for effects to be observed in the future. In summary, air pollution exposure during development affects subjects in a time-and sex-dependent manner, the postnatal period being more important and being males apparently more sensitive to exposure than females. Nevertheless, additional experimental investigations should prioritize the examination of learning, impulsivity, and biochemical parameters, with particular attention provided to disparities between sexes.
Thematic Areas: Zootecnia / recursos pesqueiros Saúde coletiva Química Public, environmental & occupational health Public health, environmental and occupational health Psicología Planejamento urbano e regional / demografia Odontología Medicina iii Medicina ii Medicina i Materiais Interdisciplinar Geociências General medicine General environmental science Farmacia Environmental sciences Environmental science (miscellaneous) Environmental science (all) Ensino Engenharias iii Engenharias ii Engenharias i Enfermagem Educação física Direito Ciências biológicas iii Ciências biológicas ii Ciências biológicas i Ciências ambientais Ciências agrárias i Ciência de alimentos Biotecnología Biodiversidade Biochemistry Astronomia / física
licence for use: https://creativecommons.org/licenses/by/3.0/es/
Author's mail: jordi.blanco@urv.cat maria.cabre@urv.cat mariateresa.colomina@urv.cat
Author identifier: 0000-0001-8016-0984 0000-0003-4124-8603 0000-0002-5619-4874
Record's date: 2024-08-03
Papper version: info:eu-repo/semantics/publishedVersion
Link to the original source: https://www.sciencedirect.com/science/article/pii/S0013935123015967
Licence document URL: https://repositori.urv.cat/ca/proteccio-de-dades/
Papper original source: Environmental Research. 236 (Pt 1): 116792-
APA: Rodulfo-Cárdenas, R; Ruiz-Sobremazas, D; Biosca-Brull, J; Cabré, M; Blanco, J; López-Granero, C; Sánchez-Santed, F; Colomina, MT (2023). The influence of environmental particulate matter exposure during late gestation and early life on the risk of neurodevelopmental disorders: A systematic review of experimental evidences. Environmental Research, 236(Pt 1), 116792-. DOI: 10.1016/j.envres.2023.116792
Article's DOI: 10.1016/j.envres.2023.116792
Entity: Universitat Rovira i Virgili
Journal publication year: 2023
Publication Type: Journal Publications