Author, as appears in the article.: Espineira, S; Flores-Piñas, M; Chafino, S; Viladés, C; Negredo, E; Fernández-Arroyo, S; Mallolas, J; Villar, B; Moreno, S; Vidal, F; Rull, A; Peraire, J
Department: Medicina i Cirurgia
URV's Author/s: Espineira Vazquez, Sonia / FERNANDEZ ARROYO, SALVADOR / Peraire Forner, José Joaquin / RULL AIXA, ANNA / Vidal Marsal, Francisco / Vilades Laborda, Consuelo Gloria / Villar Navas, Beatriz
Keywords: Transcriptomics T-cell-activation Proteomics Plhiv Metabolomics Immunological non-response Genomics transcriptomics risk recovery proteomics plhiv metabolomics infected patients individuals immunological non-response haplogroups cart antiretroviral therapy aids
Abstract: Antiretroviral therapy (ART) induces persistent suppression of HIV-1 replication and gradual recovery of T-cell counts, and consequently, morbidity and mortality from HIV-related illnesses have been significantly reduced. However, in approximately 30% of people living with HIV (PLHIV) on ART, CD4+ T-cell counts fail to normalize despite ART and complete suppression of HIV viral load, resulting in severe immune dysfunction, which may represent an increased risk of clinical progression to AIDS and non-AIDS events as well as increased mortality. These patients are referred to as “immune inadequate responders”, “immunodiscordant responders” or “immune nonresponders (INR)”. The molecular mechanisms underlying poor CD4+ T-cell recovery are still unclear. In this sense, the use of omics sciences has shed light on possible factors involved in the activity and metabolic dysregulation of immune cells during the failure of CD4+ T-cell recovery in INR. Moreover, identification of key molecules by omics approaches allows for the proposal of potential biomarkers or therapeutic targets to improve CD4+ T-cell recovery and the quality of life of these patients. Hence, this review aimed to summarize the information obtained through different omics concerning the molecular factors and pathways associated with the INR phenotype to better understand the complexity of this immunological status in HIV infection.
Thematic Areas: Zootecnia / recursos pesqueiros Saúde coletiva Química Odontología Nutrição Medicina veterinaria Medicina iii Medicina ii Medicina i Interdisciplinar Immunology and allergy Immunology Farmacia Engenharias iii Engenharias ii Ciências biológicas iii Ciências biológicas ii Ciências biológicas i Ciência de alimentos Biotecnología Biodiversidade
licence for use: https://creativecommons.org/licenses/by/3.0/es/
Author's mail: beatriz.villar@urv.cat joaquim.peraire@urv.cat consuelo.vilades@urv.cat sonia.espineira@estudiants.urv.cat beatriz.villar@urv.cat francesc.vidal@urv.cat
Author identifier: 0000-0001-7808-5479 0000-0002-2991-9593 0000-0002-6692-6186
Record's date: 2024-08-03
Papper version: info:eu-repo/semantics/publishedVersion
Link to the original source: https://www.frontiersin.org/articles/10.3389/fimmu.2023.1228795/full
Licence document URL: https://repositori.urv.cat/ca/proteccio-de-dades/
Papper original source: Frontiers In Immunology. 14
APA: Espineira, S; Flores-Piñas, M; Chafino, S; Viladés, C; Negredo, E; Fernández-Arroyo, S; Mallolas, J; Villar, B; Moreno, S; Vidal, F; Rull, A; Peraire, (2023). Multi-omics in HIV: searching insights to understand immunological non-response in PLHIV. Frontiers In Immunology, 14(), -. DOI: 10.3389/fimmu.2023.1228795
Article's DOI: 10.3389/fimmu.2023.1228795
Entity: Universitat Rovira i Virgili
Journal publication year: 2023
Publication Type: Journal Publications