Articles producció científica> Medicina i Cirurgia

Predictive Factors of the Use of Rituximab and Belimumab in Spanish Lupus Patients

  • Identification data

    Identifier: imarina:9329820
    Authors:
    Capdevila, OMitjavila, FEspinosa, GCaminal-Montero, LMarín-Ballvè, ALeón, RGCastro, ACanora, JPinilla, BFonseca, ERuiz-Irastorza, GRELESAutoimmune Dis Study Grp GEASSpanish Soc Internal Med
    Abstract:
    Objectives: To analyze the characteristics and the predictive factors of the use of rituximab and belimumab in daily practice in patients from the inception cohort Registro Espanol de Lupus (RELES). Material and methods: The study included 518 patients. We considered patients treated with biologics who received at least one dose of rituximab or belimumab, and possible indications of those manifestations registered at the same time or in the previous 2 months of the start of the therapy. Results: In our cohort, 37 (7%) patients received at least one biological treatment. Rituximab was prescribed in 26 patients and belimumab in 11. Rituximab was mainly prescribed for hemolytic anemia or thrombocytopenia (11 patients, 42%), lupus nephritis and neuropsychiatric lupus (5 patients each, 19%). Belimumab was mostly used for arthritis (8 patients, 73%). In the univariate analysis, the predictive factors at diagnosis for the use of biologic therapy were younger age (p = 0.022), a higher SLEDAI (p = 0.001) and the presence of psychosis (p = 0.011), organic mental syndrome (SOCA) (p = 0.006), hemolytic anemia (p = 0.001), or thrombocytopenia (p = 0.01). In the multivariant model, only younger age, psychosis, and hemolytic anemia were independent predictors of the use of biologics. Conclusions: Rituximab is usually given to patients with hematological, neuropsychiatric and renal involvement and belimumab for arthritis. Psychosis, hemolytic anemia and age at the diagnosis of lupus were independent predictive factors of the use of biological agents. Their global effects are beneficial, with a significant reduction in SLE activity and a low rate of side effects.
  • Others:

    Author, as appears in the article.: Capdevila, O; Mitjavila, F; Espinosa, G; Caminal-Montero, L; Marín-Ballvè, A; León, RG; Castro, A; Canora, J; Pinilla, B; Fonseca, E; Ruiz-Irastorza, G; RELES; Autoimmune Dis Study Grp GEAS; Spanish Soc Internal Med
    Department: Medicina i Cirurgia
    URV's Author/s: Castro Salomó, Antoni
    Keywords: Systemic lupus erythematosus Safety Rituximab Nephritis Erythematosus Efficacy College Cohort Belimumab
    Abstract: Objectives: To analyze the characteristics and the predictive factors of the use of rituximab and belimumab in daily practice in patients from the inception cohort Registro Espanol de Lupus (RELES). Material and methods: The study included 518 patients. We considered patients treated with biologics who received at least one dose of rituximab or belimumab, and possible indications of those manifestations registered at the same time or in the previous 2 months of the start of the therapy. Results: In our cohort, 37 (7%) patients received at least one biological treatment. Rituximab was prescribed in 26 patients and belimumab in 11. Rituximab was mainly prescribed for hemolytic anemia or thrombocytopenia (11 patients, 42%), lupus nephritis and neuropsychiatric lupus (5 patients each, 19%). Belimumab was mostly used for arthritis (8 patients, 73%). In the univariate analysis, the predictive factors at diagnosis for the use of biologic therapy were younger age (p = 0.022), a higher SLEDAI (p = 0.001) and the presence of psychosis (p = 0.011), organic mental syndrome (SOCA) (p = 0.006), hemolytic anemia (p = 0.001), or thrombocytopenia (p = 0.01). In the multivariant model, only younger age, psychosis, and hemolytic anemia were independent predictors of the use of biologics. Conclusions: Rituximab is usually given to patients with hematological, neuropsychiatric and renal involvement and belimumab for arthritis. Psychosis, hemolytic anemia and age at the diagnosis of lupus were independent predictive factors of the use of biological agents. Their global effects are beneficial, with a significant reduction in SLE activity and a low rate of side effects.
    Thematic Areas: Medicine, general & internal Medicine (miscellaneous) Medicine (all) Medicina ii General medicine Educação física
    licence for use: https://creativecommons.org/licenses/by/3.0/es/
    Author's mail: antoni.castro@urv.cat
    Author identifier: 0000-0001-5441-6333
    Record's date: 2024-08-03
    Papper version: info:eu-repo/semantics/publishedVersion
    Link to the original source: https://www.mdpi.com/1648-9144/59/8/1362
    Licence document URL: https://repositori.urv.cat/ca/proteccio-de-dades/
    Papper original source: Medicina-Lithuania. 59 (8):
    APA: Capdevila, O; Mitjavila, F; Espinosa, G; Caminal-Montero, L; Marín-Ballvè, A; León, RG; Castro, A; Canora, J; Pinilla, B; Fonseca, E; Ruiz-Irastorza, (2023). Predictive Factors of the Use of Rituximab and Belimumab in Spanish Lupus Patients. Medicina-Lithuania, 59(8), -. DOI: 10.3390/medicina59081362
    Article's DOI: 10.3390/medicina59081362
    Entity: Universitat Rovira i Virgili
    Journal publication year: 2023
    Publication Type: Journal Publications
  • Keywords:

    Medicine (Miscellaneous),Medicine, General & Internal
    Systemic lupus erythematosus
    Safety
    Rituximab
    Nephritis
    Erythematosus
    Efficacy
    College
    Cohort
    Belimumab
    Medicine, general & internal
    Medicine (miscellaneous)
    Medicine (all)
    Medicina ii
    General medicine
    Educação física
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