Author, as appears in the article.: Rios, S; García-Gavilán, JF; Babio, N; Paz-Graniel, I; Ruiz-Canela, M; Liang, LM; Clish, CB; Toledo, E; Corella, D; Estruch, R; Ros, E; Fitó, M; Arós, F; Fiol, M; Guasch-Ferré, M; Santos-Lozano, JM; Li, J; Razquin, C; Martínez-González, MA; Hu, FB; Salas-Salvadó, J
Department: Bioquímica i Biotecnologia
URV's Author/s: Babio Sánchez, Nancy Elvira / García Gavilán, Jesús Francisco / Paz Graniel, Indira del Socorro / Rios Azuara, Santiago / Salas Salvadó, Jorge
Keywords: Tandem mass spectrometry Predimed trial Neoplasms Middle aged Metabolomics Metabolite profile Life style Humans Healthy lifestyle Diabetes mellitus, type 2 Cross-sectional studies Chromatography, liquid Cardiovascular diseases Aged, 80 and over Aged
Abstract: A healthy lifestyle (HL) has been inversely related to type 2 diabetes (T2D) and cardiovascular disease (CVD). However, few studies have identified a metabolite profile associated with HL. The present study aims to identify a metabolite profile of a HL score and assess its association with the incidence of T2D and CVD in individuals at high cardiovascular risk.In a subset of 1833 participants (age 55-80y) of the PREDIMED study, we estimated adherence to a HL using a composite score based on the 2018 Word Cancer Research Fund/American Institute for Cancer Research recommendations. Plasma metabolites were analyzed using LC-MS/MS methods at baseline (discovery sample) and 1-year of follow-up (validation sample). Cross-sectional associations between 385 known metabolites and the HL score were assessed using elastic net regression. A 10-cross-validation procedure was used, and correlation coefficients or AUC were assessed between the identified metabolite profiles and the self-reported HL score. We estimated the associations between the identified metabolite profiles and T2D and CVD using multivariable Cox regression models.The metabolite profiles that identified HL as a dichotomous or continuous variable included 24 and 58 metabolites, respectively. These are amino acids or derivatives, lipids, and energy intermediates or xenobiotic compounds. After adjustment for potential confounders, baseline metabolite profiles were associated with a lower risk of T2D (hazard ratio [HR] and 95% confidence interval (CI): 0.54, 0.38-0.77 for dichotomous HL, and 0.22, 0.11-0.43 for continuous HL). Similar results were observed with CVD (HR, 95% CI: 0.59, 0.42-0.83 for dichotomous HF and HR, 95%CI: 0.58, 0.31-1.07 for continuous HL). The reduction in the risk of T2D and CVD was maintained or attenuated, respectively, for the 1-year metabolomic profile.In an elderly population at high risk of CVD, a set of metabolites was selected as potential metabolites associated with the HL pattern predicting the risk of T2D and, to a lesser extent, CVD. These results support previous findings that some of these metabolites are inversely associated with the risk of T2D and CVD.The PREDIMED trial was registered at ISRCTN ( http://www.isrctn.com/ , ISRCTN35739639).© 2023. BioMed Central Ltd., part of Springer Nature.
Thematic Areas: Saúde coletiva Medicina ii Medicina i Internal medicine Interdisciplinar Farmacia Endocrinology, diabetes and metabolism Endocrinology & metabolism Educação física Ciências biológicas ii Ciências biológicas i Cardiology and cardiovascular medicine Cardiac & cardiovascular systems Biotecnología
licence for use: https://creativecommons.org/licenses/by/3.0/es/
Author's mail: jesusfrancisco.garcia@urv.cat indiradelsocorro.paz@urv.cat jesusfrancisco.garcia@urv.cat indiradelsocorro.paz@urv.cat jordi.salas@urv.cat nancy.babio@urv.cat
Author identifier: 0000-0002-3204-6877 0000-0002-3204-6877 0000-0003-2700-7459 0000-0003-3527-5277
Record's date: 2024-08-03
Papper version: info:eu-repo/semantics/publishedVersion
Licence document URL: https://repositori.urv.cat/ca/proteccio-de-dades/
Papper original source: Cardiovascular Diabetology. 22 (1): 252-252
APA: Rios, S; García-Gavilán, JF; Babio, N; Paz-Graniel, I; Ruiz-Canela, M; Liang, LM; Clish, CB; Toledo, E; Corella, D; Estruch, R; Ros, E; Fitó, M; Arós, (2023). Plasma metabolite profiles associated with the World Cancer Research Fund/American Institute for Cancer Research lifestyle score and future risk of cardiovascular disease and type 2 diabetes. Cardiovascular Diabetology, 22(1), 252-252. DOI: 10.1186/s12933-023-01912-6
Entity: Universitat Rovira i Virgili
Journal publication year: 2023
Publication Type: Journal Publications
Repositori URV