Articles producció científica> Medicina i Cirurgia

Analysis of DNA methylation at birth and in childhood reveals changes associated with season of birth and latitude

  • Identification data

    Identifier: imarina:9329943
  • Authors:

    Kadalayil, L
    Alam, MZ
    White, CH
    Ghantous, A
    Walton, E
    Gruzieva, O
    Merid, SK
    Kumar, A
    Roy, RP
    Solomon, O
    Huen, K
    Eskenazi, B
    Rzehak, P
    Grote, V
    Langhendries, JP
    Verduci, E
    Ferre, N
    Gruszfeld, D
    Gao, L
    Guan, WH
    Zeng, XH
    Schisterman, EF
    Dou, JF
    Bakulski, KM
    Feinberg, JI
    Soomro, MH
    Pesce, G
    Baiz, N
    Isaevska, E
    Plusquin, M
    Vafeiadi, M
    Roumeliotaki, T
    Langie, SAS
    Standaert, A
    Allard, C
    Perron, P
    Bouchard, L
    van Meel, ER
    Felix, JF
    Jaddoe, VWV
    Yousefi, PD
    Ramlau-Hansen, CH
    Relton, CL
    Tobi, EW
    Starling, AP
    Yang, IV
    Llambrich, M
    Santorelli, G
    Lepeule, J
    Salas, LA
    Bustamante, M
    Ewart, SL
    Zhang, HM
    Karmaus, W
    Röder, S
    Zenclussen, AC
    Jin, JP
    Nystad, W
    Page, CM
    Magnus, M
    Jima, DD
    Hoyo, C
    Maguire, RL
    Kvist, T
    Czamara, D
    Räikkönen, K
    Gong, T
    Ullemar, V
    Rifas-Shiman, SL
    Oken, E
    Almqvist, C
    Karlsson, R
    Lahti, J
    Murphy, SK
    Håberg, SE
    London, S
    Herberth, G
    Arshad, H
    Sunyer, J
    Grazuleviciene, R
    Dabelea, D
    Steegers-Theunissen, RPM
    Nohr, EA
    Sorensen, TIA
    Duijts, L
    Hivert, MF
    Nelen, V
    Popovic, M
    Kogevinas, M
    Nawrot, TS
    Herceg, Z
    Annesi-Maesano, I
    Fallin, MD
    Yeung, EDA
    Breton, CV
    Koletzko, B
    Holland, N
    Wiemels, JL
    Melén, E
    Sharp, GC
    Silver, MJ
    Rezwan, F
    Holloway, JW
  • Others:

    Author, as appears in the article.: Kadalayil, L; Alam, MZ; White, CH; Ghantous, A; Walton, E; Gruzieva, O; Merid, SK; Kumar, A; Roy, RP; Solomon, O; Huen, K; Eskenazi, B; Rzehak, P; Grote, V; Langhendries, JP; Verduci, E; Ferre, N; Gruszfeld, D; Gao, L; Guan, WH; Zeng, XH; Schisterman, EF; Dou, JF; Bakulski, KM; Feinberg, JI; Soomro, MH; Pesce, G; Baiz, N; Isaevska, E; Plusquin, M; Vafeiadi, M; Roumeliotaki, T; Langie, SAS; Standaert, A; Allard, C; Perron, P; Bouchard, L; van Meel, ER; Felix, JF; Jaddoe, VWV; Yousefi, PD; Ramlau-Hansen, CH; Relton, CL; Tobi, EW; Starling, AP; Yang, IV; Llambrich, M; Santorelli, G; Lepeule, J; Salas, LA; Bustamante, M; Ewart, SL; Zhang, HM; Karmaus, W; Röder, S; Zenclussen, AC; Jin, JP; Nystad, W; Page, CM; Magnus, M; Jima, DD; Hoyo, C; Maguire, RL; Kvist, T; Czamara, D; Räikkönen, K; Gong, T; Ullemar, V; Rifas-Shiman, SL; Oken, E; Almqvist, C; Karlsson, R; Lahti, J; Murphy, SK; Håberg, SE; London, S; Herberth, G; Arshad, H; Sunyer, J; Grazuleviciene, R; Dabelea, D; Steegers-Theunissen, RPM; Nohr, EA; Sorensen, TIA; Duijts, L; Hivert, MF; Nelen, V; Popovic, M; Kogevinas, M; Nawrot, TS; Herceg, Z; Annesi-Maesano, I; Fallin, MD; Yeung, EDA; Breton, CV; Koletzko, B; Holland, N; Wiemels, JL; Melén, E; Sharp, GC; Silver, MJ; Rezwan, F; Holloway, JW
    Department: Medicina i Cirurgia
    URV's Author/s: Ferre Pallas, Natalia / Llambrich Rodriguez, Maria
    Keywords: Seasons Risk Pace Meta-analysis Latitude Inflammation Infant, newborn Infant Humans Dna methylation Differentially methylated regions (dmr) Child, preschool Child Carcinogenesis Birth season Asthma schizophrenia prevalence pregnancy metaanalysis meta-analysis latitude gender dna methylation disease discovery differentially methylated regions (dmr) depends children birth season
    Abstract: Seasonal variations in environmental exposures at birth or during gestation are associated with numerous adult traits and health outcomes later in life. Whether DNA methylation (DNAm) plays a role in the molecular mechanisms underlying the associations between birth season and lifelong phenotypes remains unclear.We carried out epigenome-wide meta-analyses within the Pregnancy And Childhood Epigenetic Consortium to identify associations of DNAm with birth season, both at differentially methylated probes (DMPs) and regions (DMRs). Associations were examined at two time points: at birth (21 cohorts, N = 9358) and in children aged 1-11 years (12 cohorts, N = 3610). We conducted meta-analyses to assess the impact of latitude on birth season-specific associations at both time points.We identified associations between birth season and DNAm (False Discovery Rate-adjusted p values < 0.05) at two CpGs at birth (winter-born) and four in the childhood (summer-born) analyses when compared to children born in autumn. Furthermore, we identified twenty-six differentially methylated regions (DMR) at birth (winter-born: 8, spring-born: 15, summer-born: 3) and thirty-two in childhood (winter-born: 12, spring and summer: 10 each) meta-analyses with few overlapping DMRs between the birth seasons or the two time points. The DMRs were associated with genes of known functions in tumorigenesis, psychiatric/neurological disorders, inflammation, or immunity, amongst others. Latitude-stratified meta-analyses [higher (≥ 50°N), lower (< 50°N, northern hemisphere only)] revealed differences in associations between birth season and DNAm by birth latitude. DMR analysis implicated genes with previously reported links to schizophrenia (LAX1), skin disorders (PSORS1C, LTB4R), and airway inflammation including asthma (LTB4R), present only at birth in the higher latitudes (≥ 50°N).In this large epigenome-wide meta-analysis study, we provide evidence for (i) associations between DNAm and season of birth that are unique for the seasons of the year (temporal effect) and (ii) latitude-dependent variations in the seasonal associations (spatial effect). DNAm could play a role in the molecular mechanisms underlying the effect of birth season on adult health outcomes.© 2023. BioMed Central Ltd., part of Springer Nature.
    Thematic Areas: Oncology Odontología Molecular biology Medicina i Genetics (clinical) Genetics & heredity Genetics General medicine Developmental biology Ciências biológicas ii Ciências biológicas i Biotecnología
    licence for use: https://creativecommons.org/licenses/by/3.0/es/
    Author's mail: maria.llambrich@urv.cat maria.llambrich@urv.cat natalia.ferre@urv.cat
    Author identifier: 0000-0001-8418-0982 0000-0001-8418-0982 0000-0002-2838-1525
    Record's date: 2024-07-20
    Papper version: info:eu-repo/semantics/publishedVersion
    Link to the original source: https://clinicalepigeneticsjournal.biomedcentral.com/articles/10.1186/s13148-023-01542-5
    Licence document URL: http://repositori.urv.cat/ca/proteccio-de-dades/
    Papper original source: Clinical Epigenetics. 15 (1): 148-148
    APA: Kadalayil, L; Alam, MZ; White, CH; Ghantous, A; Walton, E; Gruzieva, O; Merid, SK; Kumar, A; Roy, RP; Solomon, O; Huen, K; Eskenazi, B; Rzehak, P; Gro (2023). Analysis of DNA methylation at birth and in childhood reveals changes associated with season of birth and latitude. Clinical Epigenetics, 15(1), 148-148. DOI: 10.1186/s13148-023-01542-5
    Article's DOI: 10.1186/s13148-023-01542-5
    Entity: Universitat Rovira i Virgili
    Journal publication year: 2023
    Publication Type: Journal Publications
  • Keywords:

    Developmental Biology,Genetics,Genetics & Heredity,Genetics (Clinical),Molecular Biology,Oncology
    Seasons
    Risk
    Pace
    Meta-analysis
    Latitude
    Inflammation
    Infant, newborn
    Infant
    Humans
    Dna methylation
    Differentially methylated regions (dmr)
    Child, preschool
    Child
    Carcinogenesis
    Birth season
    Asthma
    schizophrenia
    prevalence
    pregnancy
    metaanalysis
    meta-analysis
    latitude
    gender
    dna methylation
    disease
    discovery
    differentially methylated regions (dmr)
    depends
    children
    birth season
    Oncology
    Odontología
    Molecular biology
    Medicina i
    Genetics (clinical)
    Genetics & heredity
    Genetics
    General medicine
    Developmental biology
    Ciências biológicas ii
    Ciências biológicas i
    Biotecnología
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