Author, as appears in the article.: Descamps-Solà M; Vilalta A; Jalsevac F; Blay MT; Rodríguez-Gallego E; Pinent M; Beltrán-Debón R; Terra X; Ardévol A
Department: Bioquímica i Biotecnologia
URV's Author/s: Ardévol Grau, Anna / Beltrán Debón, Raúl Alejandro / Blay Olivé, Maria Teresa / Pinent Armengol, Montserrat / Terra Barbadora, Ximena
Project code: Grant agreement No. 945413
Keywords: Taste sensing Orthology Nutrient sensors Gut Extraoral tas2r
Abstract: For decades bitter taste receptors (TAS2R) were thought to be located only in the mouth and to serve as sensors for nutrients and harmful substances. However, in recent years Tas2r have also been reported in extraoral tissues such as the skin, the lungs, and the intestine, where their function is still uncertain. To better understand the physiological role of these receptors, in this paper we focused on the intestine, an organ in which their activation may be similar to the receptors found in the mouth. We compare the relative presence of these receptors along the gastrointestinal tract in three main species of biomedical research (mice, rats and humans) using sequence homology. Current data from studies of rodents are scarce and while more data are available in humans, they are still deficient. Our results indicate, unexpectedly, that the reported expression profiles do not always coincide between species even if the receptors are orthologs. This may be due not only to evolutionary divergence of the species but also to their adaptation to different dietary patterns. Further studies are needed in order to develop an integrated vision of these receptors and their physiological functionality along the gastrointestinal tract.
Thematic Areas: Saúde coletiva Nutrition and dietetics Nutrition & dietetics Nutrição Medicina i Interdisciplinar Food science Endocrinology, diabetes and metabolism Educação física
licence for use: https://creativecommons.org/licenses/by/3.0/es/
Author's mail: raul.beltran@urv.cat montserrat.pinent@urv.cat mteresa.blay@urv.cat ximena.terra@urv.cat anna.ardevol@urv.cat
Author identifier: 0000-0001-9691-1906 0000-0003-3550-5378 0000-0002-6256-9847 0000-0003-1043-5844 0000-0003-0156-7538
Record's date: 2024-06-22
Papper version: info:eu-repo/semantics/publishedVersion
Link to the original source: https://www.frontiersin.org/articles/10.3389/fnut.2023.1215889/full
Funding program: Marie Sklodowska-Curie Actions – European Union’s Horizon 2020 research and innovation programme
Licence document URL: http://repositori.urv.cat/ca/proteccio-de-dades/
Papper original source: Front Nutr. 10
APA: Descamps-Solà M; Vilalta A; Jalsevac F; Blay MT; Rodríguez-Gallego E; Pinent M; Beltrán-Debón R; Terra X; Ardévol A (2023). Bitter taste receptors along the gastrointestinal tract: comparison between humans and rodents. Front Nutr, 10(), -. DOI: 10.3389/fnut.2023.1215889
Acronym: MFP-Plus
Article's DOI: 10.3389/fnut.2023.1215889
Entity: Universitat Rovira i Virgili
Journal publication year: 2023
Funding program action: Martí i Franquès COFUND Doctoral Programme
Publication Type: Journal Publications
Repositori URV