Author, as appears in the article.: Sánchez, A; García-Pardo, G; Gómez-Bertomeu, F; López-Dupla, M; Foguet-Romero, E; Buzón, MJ; Almirante, B; Olona, M; Fernández-Veledo, S; Vidal, F; Chafino, S; Rull, A
Department: Ciències Mèdiques Bàsiques Medicina i Cirurgia
URV's Author/s: Fernandez Veledo, Sonia / Garcia Pardo, Graciano / Gomez Bertomeu, Frederic-Francesc / López Dupla, Jesús Miguel / Olona Cabases, Maria Montserrat / Peraire Forner, José Joaquin / RULL AIXA, ANNA / Sánchez Marín, Antonio / Vidal Marsal, Francisco
Keywords: Human metabolism Biological sciences
Abstract: The metabolic alterations caused by SARS-CoV-2 infection reflect disease progression. To analyze molecules involved in these metabolic changes, a multiomics study was performed using plasma from 103 patients with different degrees of COVID-19 severity during the evolution of the infection. With the increased severity of COVID-19, changes in circulating proteomic, metabolomic, and lipidomic profiles increased. Notably, the group of severe and critical patients with high HRG and ChoE (20:3) and low alpha-ketoglutaric acid levels had a high chance of unfavorable disease evolution (AUC = 0.925). Consequently, patients with the worst prognosis presented alterations in the TCA cycle (mitochondrial dysfunction), lipid metabolism, amino acid biosynthesis, and coagulation. Our findings increase knowledge regarding how SARS-CoV-2 infection affects different metabolic pathways and help in understanding the future consequences of COVID-19 to identify potential therapeutic targets.
Thematic Areas: Multidisciplinary sciences Multidisciplinary
licence for use: https://creativecommons.org/licenses/by/3.0/es/
Author's mail: graciano.garcia@urv.cat sonia.fernandez@urv.cat mariamontserrat.olona@urv.cat antonio.sanchez@urv.cat frederic-francesc.gomez@urv.cat joaquim.peraire@urv.cat jesusmiguel.lopez@urv.cat francesc.vidal@urv.cat
Author identifier: 0000-0003-2906-3788 0009-0003-7711-3281 0000-0002-8039-2889 0000-0001-7808-5479 0000-0002-9141-2523 0000-0002-6692-6186
Record's date: 2024-03-09
Papper version: info:eu-repo/semantics/publishedVersion
Link to the original source: https://www.cell.com/iscience/fulltext/S2589-0042(23)02025-4?_returnURL=https%3A%2F%2Flinkinghub.elsevier.com%2Fretrieve%2Fpii%2FS2589004223020254%3Fshowall%3Dtrue#%20
Licence document URL: http://repositori.urv.cat/ca/proteccio-de-dades/
Papper original source: Iscience. 26 (10): 107948-
APA: Sánchez, A; García-Pardo, G; Gómez-Bertomeu, F; López-Dupla, M; Foguet-Romero, E; Buzón, MJ; Almirante, B; Olona, M; Fernández-Veledo, S; Vidal, F; Ch (2023). Mitochondrial dysfunction, lipids metabolism, and amino acid biosynthesis are key pathways for COVID-19 recovery. Iscience, 26(10), 107948-. DOI: 10.1016/j.isci.2023.107948
Article's DOI: 10.1016/j.isci.2023.107948
Entity: Universitat Rovira i Virgili
Journal publication year: 2023
Publication Type: Journal Publications
Repositori URV