Articles producció científica> Ciències Mèdiques Bàsiques

Effects of an organic diet intervention on the levels of organophosphorus metabolites in an adult cohort

  • Identification data

    Identifier: imarina:9330537
    Authors:
    González, NPàmies, CMartinez, PMartí, LDomingo, JLNadal, MMarquès, M
    Abstract:
    Pesticides are a group of organic compounds used to control weeds or insect infestations in agriculture. Diet is the major route of human exposure to these compounds, which can cause serious health problems, even when the intake occurs at low concentrations. Hence, the consumption of organic food is an appropriate strategy to minimize the exposure to pesticides. A prospective, randomized study was conducted to assess the impact of an organic dietary intervention on the levels of urinary dialkyl phosphates (DAP). A screening of 204 pesticides was also carried out in order to confirm the absence of these compounds in organic food. The analytical results showed that only 20 of the 204 pesticides (9.8 %) had concentrations above the limit of quantification in one or more samples of the organic food consumed by the participants. It is substantially lower than the levels of pesticides found in other studies analysing conventional food, confirming the diet as suitable for the organic dietary intervention. A general reduction of most DAP metabolites in urine was found, being significant (p < 0.05) the decrease of dimethyl phosphate (DMP) (0.49 µg/g creatinine in Day 1 vs. 0.062 µg/g creatinine in Day 6), dimethyl thiophosphate (DMTP) (0.49 µg/g creatinine in Day 1 vs. 0.093 µg/g creatinine in Day 6) and diethyl phosphate (DEP) (0.28 µg/g creatinine in Day 1 vs. 0.12 µg/g creatinine in Day 6). In addition, the molar score for the total dimethyl DAP (ΣMP) and total dialkyl phosphate (ΣDAP) also showed significant differences after changing a conventional diet by an organic diet, being reduced from 0.008 µmol/g to 0.002 µmol/g for ΣMP and from 0.012 µmol/g to 0.003 µmol/g for ΣDAP. To the best of our knowledge, this is the first study that evaluates both the impact of an organic d
  • Others:

    Author, as appears in the article.: González, N; Pàmies, C; Martinez, P; Martí, L; Domingo, JL; Nadal, M; Marquès, M
    Department: Ciències Mèdiques Bàsiques
    URV's Author/s: Domingo Roig, José Luis / Gonzalez Paradell, Nieves / Marquès Bueno, Montserrat / Martínez Cánovas, Paula / Nadal Lomas, Martí
    Keywords: Urine analysis Pesticides Organic food products Dietary exposure Dialkyl phosphates Dialkyl phosphate metabolites Biomonitoring urine analysis urinary concentrations risk residues reduction pesticides pesticide metabolites parameters organic food products exposure dietary exposure dialkyl phosphates
    Abstract: Pesticides are a group of organic compounds used to control weeds or insect infestations in agriculture. Diet is the major route of human exposure to these compounds, which can cause serious health problems, even when the intake occurs at low concentrations. Hence, the consumption of organic food is an appropriate strategy to minimize the exposure to pesticides. A prospective, randomized study was conducted to assess the impact of an organic dietary intervention on the levels of urinary dialkyl phosphates (DAP). A screening of 204 pesticides was also carried out in order to confirm the absence of these compounds in organic food. The analytical results showed that only 20 of the 204 pesticides (9.8 %) had concentrations above the limit of quantification in one or more samples of the organic food consumed by the participants. It is substantially lower than the levels of pesticides found in other studies analysing conventional food, confirming the diet as suitable for the organic dietary intervention. A general reduction of most DAP metabolites in urine was found, being significant (p < 0.05) the decrease of dimethyl phosphate (DMP) (0.49 µg/g creatinine in Day 1 vs. 0.062 µg/g creatinine in Day 6), dimethyl thiophosphate (DMTP) (0.49 µg/g creatinine in Day 1 vs. 0.093 µg/g creatinine in Day 6) and diethyl phosphate (DEP) (0.28 µg/g creatinine in Day 1 vs. 0.12 µg/g creatinine in Day 6). In addition, the molar score for the total dimethyl DAP (ΣMP) and total dialkyl phosphate (ΣDAP) also showed significant differences after changing a conventional diet by an organic diet, being reduced from 0.008 µmol/g to 0.002 µmol/g for ΣMP and from 0.012 µmol/g to 0.003 µmol/g for ΣDAP. To the best of our knowledge, this is the first study that evaluates both the impact of an organic diet in the exposure to DAP and the levels of 204 pesticides in the organic food provided to the participants. In summary, the consumption of organic products decreases the dietary intake of pesticides, thus reducing also the potential adverse effects on human health.Copyright © 2023 The Author(s). Published by Elsevier Ltd.. All rights reserved.
    Thematic Areas: Zootecnia / recursos pesqueiros Saúde coletiva Química Odontología Nutrição Medicina veterinaria Medicina ii Medicina i Materiais Matemática / probabilidade e estatística Interdisciplinar Food science & technology Food science Farmacia Ensino Engenharias iv Engenharias iii Engenharias ii Engenharias i Educação Ciências biológicas iii Ciências biológicas ii Ciências biológicas i Ciências ambientais Ciências agrárias i Ciência de alimentos Ciência da computação Biotecnología Biodiversidade Astronomia / física Administração pública e de empresas, ciências contábeis e turismo
    licence for use: https://creativecommons.org/licenses/by/3.0/es/
    Author's mail: marti.nadal@urv.cat paula.martinez@urv.cat nieves.gonzalez@urv.cat montserrat.marques@urv.cat paula.martinez@urv.cat joseluis.domingo@urv.cat marti.nadal@urv.cat
    Author identifier: 0000-0002-0217-4827 0000-0003-4134-016X 0000-0001-6302-8578 0000-0001-6647-9470 0000-0002-0217-4827
    Record's date: 2024-08-03
    Papper version: info:eu-repo/semantics/publishedVersion
    Licence document URL: https://repositori.urv.cat/ca/proteccio-de-dades/
    Papper original source: Food Research International. 173 (Pt 1): 113354-113354
    APA: González, N; Pàmies, C; Martinez, P; Martí, L; Domingo, JL; Nadal, M; Marquès, M (2023). Effects of an organic diet intervention on the levels of organophosphorus metabolites in an adult cohort. Food Research International, 173(Pt 1), 113354-113354. DOI: 10.1016/j.foodres.2023.113354
    Entity: Universitat Rovira i Virgili
    Journal publication year: 2023
    Publication Type: Journal Publications
  • Keywords:

    Food Science,Food Science & Technology
    Urine analysis
    Pesticides
    Organic food products
    Dietary exposure
    Dialkyl phosphates
    Dialkyl phosphate metabolites
    Biomonitoring
    urine analysis
    urinary concentrations
    risk
    residues
    reduction
    pesticides
    pesticide metabolites
    parameters
    organic food products
    exposure
    dietary exposure
    dialkyl phosphates
    Zootecnia / recursos pesqueiros
    Saúde coletiva
    Química
    Odontología
    Nutrição
    Medicina veterinaria
    Medicina ii
    Medicina i
    Materiais
    Matemática / probabilidade e estatística
    Interdisciplinar
    Food science & technology
    Food science
    Farmacia
    Ensino
    Engenharias iv
    Engenharias iii
    Engenharias ii
    Engenharias i
    Educação
    Ciências biológicas iii
    Ciências biológicas ii
    Ciências biológicas i
    Ciências ambientais
    Ciências agrárias i
    Ciência de alimentos
    Ciência da computação
    Biotecnología
    Biodiversidade
    Astronomia / física
    Administração pública e de empresas, ciências contábeis e turismo
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