Author, as appears in the article.: Shyam, S; Garcia-Gavilan, JF; Paz-Graniel, I; Gaforio, JJ; Martinez-Gonzalez, MA; Corella, D; Martinez, JA; Alonso-Gomez, AM; Waernberg, J; Vioque, J; Romaguera, D; Lopez-Miranda, J; Estruch, R; Tinahones, FJ; Lapetra, J; Serra-Majem, JL; Bueno-Cavanillas, A; Tur, JA; Sanchez, VM; Pinto, X; Matia-Martin, P; Vidal, J; Vazquez, C; Daimiel, L; Ros, E; Fernandez-Aranda, F; Nishi, SK; Garcia-Regata, O; Toledo, E; Asensio, EM; Castaner, O; Garcia-Rios, A; Torres-Collado, L; Gomez-Gracia, E; Zulet, MA; Ruiz, NG; Casas, R; Cano-Ibanez, N; Tojal-Sierra, L; Gomez-Perez, AM; Sorli, JV; Cinza-Sanjurjo, S; Martin-Pelaez, S; Pena-Orihuela, PJ; Oncina-Canovas, A; Perez-Araluce, R; Zomeno, MD; Chaplin, A; Delgado-Rodriguez, M; Babio, N; Fito, M; Salas-Salvado, J
Department: Bioquímica i Biotecnologia
URV's Author/s: Babio Sánchez, Nancy Elvira / García Gavilán, Jesús Francisco / Nishi, Stephanie Kimiko / Paz Graniel, Indira del Socorro / Salas Salvadó, Jorge / Shyam, Sangeetha
Keywords: Weight loss Waist circumference Risk factors Overweight Older adults Obesity Middle aged Metabolic syndrome Mediterranean diet adherence Male Humans Female Covid-19 Central obesity Body weight Body mass index Aged Adiposity weight loss older adults mortality covid-19 central obesity
Abstract: Cross-sectionally, older age and obesity are associated with increased coronavirus disease-2019 (COVID-19) risk. We assessed the longitudinal associations of baseline and changes in adiposity parameters with COVID-19 incidence in older adults at high cardiovascular risk.This analysis included 6874 men and women (aged 55-75 years) with overweight/obesity and metabolic syndrome in the PREDIMED-Plus lifestyle intervention trial for cardiovascular risk reduction. Body weight, body-mass-index (BMI), waist circumference, waist-to-height ratio (WHtR), and a body shape index (ABSI) were measured at baseline and annual follow-up visits. COVID-19 was ascertained by an independent Event Committee until 31 December 2021. Cox regression models were fitted to evaluate the risk of COVID-19 incidence based on baseline adiposity parameters measured 5-6 years before the pandemic and their changes at the visit prior to censoring.At the time of censoring, 653 incident COVID-19 cases occurred. Higher baseline body weight, BMI, waist circumference, and WHtR were associated with increased COVID-19 risk. During the follow-up, every unit increase in body weight (HRadj (95%CI): 1.01 (1.00, 1.03)) and BMI (HRadj: 1.04 (1.003, 1.08)) was associated with increased COVID-19 risk.In older adults with overweight/obesity, clinically significant weight loss may protect against COVID-19.This study is registered at the International Standard Randomized Controlled Trial (ISRCT; http://www.isrctn.com/ISRCTN89898870 ).© 2023. BioMed Central Ltd., part of Springer Nature.
Thematic Areas: Saúde coletiva Medicine, general & internal Medicine (miscellaneous) Medicine (all) Medicina veterinaria Medicina ii Medicina i General medicine Ciências biológicas iii Ciências biológicas ii Ciências biológicas i
licence for use: https://creativecommons.org/licenses/by/3.0/es/
Author's mail: sangeetha.shyam@urv.cat stephanie.nishi@urv.cat jesusfrancisco.garcia@urv.cat indiradelsocorro.paz@urv.cat nancy.babio@urv.cat jordi.salas@urv.cat indiradelsocorro.paz@urv.cat jesusfrancisco.garcia@urv.cat
Author identifier: 0000-0002-3204-6877 0000-0003-3527-5277 0000-0003-2700-7459 0000-0002-3204-6877
Record's date: 2024-06-28
Papper version: info:eu-repo/semantics/publishedVersion
Link to the original source: https://bmcmedicine.biomedcentral.com/articles/10.1186/s12916-023-03079-z
Licence document URL: http://repositori.urv.cat/ca/proteccio-de-dades/
Papper original source: Bmc Medicine. 21 (1): 390-390
APA: Shyam, S; Garcia-Gavilan, JF; Paz-Graniel, I; Gaforio, JJ; Martinez-Gonzalez, MA; Corella, D; Martinez, JA; Alonso-Gomez, AM; Waernberg, J; Vioque, J; (2023). Association of adiposity and its changes over time with COVID-19 risk in older adults with overweight/obesity and metabolic syndrome: a longitudinal evaluation in the PREDIMED-Plus cohort. Bmc Medicine, 21(1), 390-390. DOI: 10.1186/s12916-023-03079-z
Article's DOI: 10.1186/s12916-023-03079-z
Entity: Universitat Rovira i Virgili
Journal publication year: 2023
Publication Type: Journal Publications
Repositori URV