Articles producció científica> Bioquímica i Biotecnologia

Association of adiposity and its changes over time with COVID-19 risk in older adults with overweight/obesity and metabolic syndrome: a longitudinal evaluation in the PREDIMED-Plus cohort

  • Identification data

    Identifier: imarina:9330686
    Handle: https://hdl.handle.net/20.500.11797/imarina9330686
    Authors:
    Shyam, SGarcia-Gavilan, JFPaz-Graniel, IGaforio, JJMartinez-Gonzalez, MACorella, DMartinez, JAAlonso-Gomez, AMWaernberg, JVioque, JRomaguera, DLopez-Miranda, JEstruch, RTinahones, FJLapetra, JSerra-Majem, JLBueno-Cavanillas, ATur, JASanchez, VMPinto, XMatia-Martin, PVidal, JVazquez, CDaimiel, LRos, EFernandez-Aranda, FNishi, SKGarcia-Regata, OToledo, EAsensio, EMCastaner, OGarcia-Rios, ATorres-Collado, LGomez-Gracia, EZulet, MARuiz, NGCasas, RCano-Ibanez, NTojal-Sierra, LGomez-Perez, AMSorli, JVCinza-Sanjurjo, SMartin-Pelaez, SPena-Orihuela, PJOncina-Canovas, APerez-Araluce, RZomeno, MDChaplin, ADelgado-Rodriguez, MBabio, NFito, MSalas-Salvado, J
    Abstract:
    Cross-sectionally, older age and obesity are associated with increased coronavirus disease-2019 (COVID-19) risk. We assessed the longitudinal associations of baseline and changes in adiposity parameters with COVID-19 incidence in older adults at high cardiovascular risk.This analysis included 6874 men and women (aged 55-75 years) with overweight/obesity and metabolic syndrome in the PREDIMED-Plus lifestyle intervention trial for cardiovascular risk reduction. Body weight, body-mass-index (BMI), waist circumference, waist-to-height ratio (WHtR), and a body shape index (ABSI) were measured at baseline and annual follow-up visits. COVID-19 was ascertained by an independent Event Committee until 31 December 2021. Cox regression models were fitted to evaluate the risk of COVID-19 incidence based on baseline adiposity parameters measured 5-6 years before the pandemic and their changes at the visit prior to censoring.At the time of censoring, 653 incident COVID-19 cases occurred. Higher baseline body weight, BMI, waist circumference, and WHtR were associated with increased COVID-19 risk. During the follow-up, every unit increase in body weight (HRadj (95%CI): 1.01 (1.00, 1.03)) and BMI (HRadj: 1.04 (1.003, 1.08)) was associated with increased COVID-19 risk.In older adults with overweight/obesity, clinically significant weight loss may protect against COVID-19.This study is registered at the International Standard Randomized Controlled Trial (ISRCT; http://www.isrctn.com/ISRCTN89898870 ).© 2023. BioMed Central Ltd., part of Springer Nature.

  • Others:

    Author, as appears in the article.: Shyam, S; Garcia-Gavilan, JF; Paz-Graniel, I; Gaforio, JJ; Martinez-Gonzalez, MA; Corella, D; Martinez, JA; Alonso-Gomez, AM; Waernberg, J; Vioque, J; Romaguera, D; Lopez-Miranda, J; Estruch, R; Tinahones, FJ; Lapetra, J; Serra-Majem, JL; Bueno-Cavanillas, A; Tur, JA; Sanchez, VM; Pinto, X; Matia-Martin, P; Vidal, J; Vazquez, C; Daimiel, L; Ros, E; Fernandez-Aranda, F; Nishi, SK; Garcia-Regata, O; Toledo, E; Asensio, EM; Castaner, O; Garcia-Rios, A; Torres-Collado, L; Gomez-Gracia, E; Zulet, MA; Ruiz, NG; Casas, R; Cano-Ibanez, N; Tojal-Sierra, L; Gomez-Perez, AM; Sorli, JV; Cinza-Sanjurjo, S; Martin-Pelaez, S; Pena-Orihuela, PJ; Oncina-Canovas, A; Perez-Araluce, R; Zomeno, MD; Chaplin, A; Delgado-Rodriguez, M; Babio, N; Fito, M; Salas-Salvado, J
    Department: Bioquímica i Biotecnologia
    URV's Author/s: Babio Sánchez, Nancy Elvira / García Gavilán, Jesús Francisco / Nishi, Stephanie Kimiko / Paz Graniel, Indira del Socorro / Salas Salvadó, Jorge / Shyam, Sangeetha
    Keywords: Weight loss Waist circumference Risk factors Overweight Older adults Obesity Middle aged Metabolic syndrome Mediterranean diet adherence Male Humans Female Covid-19 Central obesity Body weight Body mass index Aged Adiposity weight loss older adults mortality covid-19 central obesity
    Abstract: Cross-sectionally, older age and obesity are associated with increased coronavirus disease-2019 (COVID-19) risk. We assessed the longitudinal associations of baseline and changes in adiposity parameters with COVID-19 incidence in older adults at high cardiovascular risk.This analysis included 6874 men and women (aged 55-75 years) with overweight/obesity and metabolic syndrome in the PREDIMED-Plus lifestyle intervention trial for cardiovascular risk reduction. Body weight, body-mass-index (BMI), waist circumference, waist-to-height ratio (WHtR), and a body shape index (ABSI) were measured at baseline and annual follow-up visits. COVID-19 was ascertained by an independent Event Committee until 31 December 2021. Cox regression models were fitted to evaluate the risk of COVID-19 incidence based on baseline adiposity parameters measured 5-6 years before the pandemic and their changes at the visit prior to censoring.At the time of censoring, 653 incident COVID-19 cases occurred. Higher baseline body weight, BMI, waist circumference, and WHtR were associated with increased COVID-19 risk. During the follow-up, every unit increase in body weight (HRadj (95%CI): 1.01 (1.00, 1.03)) and BMI (HRadj: 1.04 (1.003, 1.08)) was associated with increased COVID-19 risk.In older adults with overweight/obesity, clinically significant weight loss may protect against COVID-19.This study is registered at the International Standard Randomized Controlled Trial (ISRCT; http://www.isrctn.com/ISRCTN89898870 ).© 2023. BioMed Central Ltd., part of Springer Nature.
    Thematic Areas: Saúde coletiva Medicine, general & internal Medicine (miscellaneous) Medicine (all) Medicina veterinaria Medicina ii Medicina i General medicine Ciências biológicas iii Ciências biológicas ii Ciências biológicas i
    licence for use: https://creativecommons.org/licenses/by/3.0/es/
    Author's mail: sangeetha.shyam@urv.cat jesusfrancisco.garcia@urv.cat stephanie.nishi@urv.cat indiradelsocorro.paz@urv.cat jesusfrancisco.garcia@urv.cat indiradelsocorro.paz@urv.cat jordi.salas@urv.cat nancy.babio@urv.cat
    Author identifier: 0000-0002-3204-6877 0000-0002-3204-6877 0000-0003-2700-7459 0000-0003-3527-5277
    Record's date: 2024-08-03
    Papper version: info:eu-repo/semantics/publishedVersion
    Link to the original source: https://bmcmedicine.biomedcentral.com/articles/10.1186/s12916-023-03079-z
    Licence document URL: https://repositori.urv.cat/ca/proteccio-de-dades/
    Papper original source: Bmc Medicine. 21 (1): 390-390
    APA: Shyam, S; Garcia-Gavilan, JF; Paz-Graniel, I; Gaforio, JJ; Martinez-Gonzalez, MA; Corella, D; Martinez, JA; Alonso-Gomez, AM; Waernberg, J; Vioque, J; (2023). Association of adiposity and its changes over time with COVID-19 risk in older adults with overweight/obesity and metabolic syndrome: a longitudinal evaluation in the PREDIMED-Plus cohort. Bmc Medicine, 21(1), 390-390. DOI: 10.1186/s12916-023-03079-z
    Article's DOI: 10.1186/s12916-023-03079-z
    Entity: Universitat Rovira i Virgili
    Journal publication year: 2023
    Publication Type: Journal Publications

  • Keywords:

    Medicine (Miscellaneous),Medicine, General & Internal
    Weight loss
    Waist circumference
    Risk factors
    Overweight
    Older adults
    Obesity
    Middle aged
    Metabolic syndrome
    Mediterranean diet adherence
    Male
    Humans
    Female
    Covid-19
    Central obesity
    Body weight
    Body mass index
    Aged
    Adiposity
    weight loss
    older adults
    mortality
    covid-19
    central obesity
    Saúde coletiva
    Medicine, general & internal
    Medicine (miscellaneous)
    Medicine (all)
    Medicina veterinaria
    Medicina ii
    Medicina i
    General medicine
    Ciências biológicas iii
    Ciências biológicas ii
    Ciências biológicas i

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