Repositori URV

Author, as appears in the article.: Valle-Hita, C; Díaz-López, A; Becerra-Tomás, N; Toledo, E; Cornejo-Pareja, I; Abete, I; Sureda, A; Bes-Rastrollo, M; Martínez, JA; Tinahones, FJ; Tur, JA; Garcidueñas-Fimbres, TE; París-Pallejá, F; Goday, A; Goñi-Ruiz, N; Salas-Salvadó, J; Babio, N

Department: Bioquímica i Biotecnologia

URV's Author/s: Babio Sánchez, Nancy Elvira / Becerra Tomás, Nerea / Díaz López, Andres / GARCIDUEÑAS FIMBRES, TANY ELIZABETH / Salas Salvadó, Jorge / Valle Hita, Cristina

Keywords: Ultra-processed food Ultra -processed food Kidney function decline Glomerular filtration rate Dietary fiber Cystatin c sugar risk kidney function decline glomerular filtration rate gfr disease cystatin-c cystatin c creatinine

Abstract: Background & aims: Ultra-processed food (UPF) consumption has increased dramatically over the last decades worldwide. Although it has been linked to some cardiometabolic comorbidities, there is limited evidence regarding kidney function. This study aimed to cross-sectionally and longitudinally assess the association between UPF consumption and estimated-glomerular filtration rate (eGFR) based on Cystatin C (CysC). Methods: Older adults (mean age 65 ± 5.0 years, 46% women) with overweight/obesity and metabolic syndrome (MetS) who had available data of CysC at baseline (n = 1909), at one-year and at 3-years of follow-up (n = 1700) were analyzed. Food consumption was assessed using a validated 143-item semi-quantitative food frequency questionnaire and UPF consumption (% of g/d) at baseline and changes after one-year of follow-up were estimated according to NOVA classification system. Multivariable-adjusted linear and logistic regression models were performed to evaluate the cross-sectional associations between UPF consumption with eGFR levels and decreased kidney function (eGFR <60 ml/min/1.73 m2) at baseline. Multivariable-adjusted mixed-effects linear regression models were fitted to investigate the associations between one-year changes in UPF and eGFR over 3-years of follow-up. Results: Individuals with the highest baseline UPF consumption showed lower eGFR (β: −3.39 ml/min/1.73 m2; 95% CI: −5.59 to −1.20) and higher odds of decreased kidney function (OR: 1.64; 95% CI: 1.21 to 2.22) at baseline, compared to individuals in the lowest tertile. Participants in the highest tertile of one-year changes in UPF consumption presented a significant decrease in eGFR after one-year of follow-up (β: −1.45 ml/min/1.73 m2; 95% CI: −2.90 to −0.01) as well as after 3-years of follow-up (β: −2.18 ml/min/1.73 m2; 95% CI: −3.71 to −0.65) compared to those in the reference category. Conclusions: In a Mediterranean population of older adults with overweight/obesity and MetS, higher UPF consumption at baseline and one-year changes towards higher consumption of UPF were associated with worse kidney function at baseline and over 3-years of follow-up, respectively. Clinical Trial Registry number: ISRCTN89898870.

Thematic Areas: Saúde coletiva Química Odontología Nutrition and dietetics Nutrition & dietetics Nutrição Medicina iii Medicina ii Medicina i Interdisciplinar General medicine Farmacia Engenharias iv Enfermagem Educação física Critical care and intensive care medicine Ciências biológicas iii Ciências biológicas ii Ciências biológicas i Ciência de alimentos Biotecnología

licence for use: https://creativecommons.org/licenses/by/3.0/es/

Author's mail: tanyelizabeth.garciduenas@urv.cat andres.diaz@urv.cat nerea.becerra@urv.cat tanyelizabeth.garciduenas@urv.cat tanyelizabeth.garciduenas@urv.cat cristina.valle@urv.cat jordi.salas@urv.cat nancy.babio@urv.cat

Author identifier: 0000-0002-7500-5629 0000-0002-4429-6507 0000-0003-2700-7459 0000-0003-3527-5277

Record's date: 2024-08-03

Papper version: info:eu-repo/semantics/publishedVersion

Link to the original source: https://www.clinicalnutritionjournal.com/article/S0261-5614(23)00317-5/fulltext#%20

Licence document URL: https://repositori.urv.cat/ca/proteccio-de-dades/

Papper original source: Clinical Nutrition. 42 (12): 2302-2310

APA: Valle-Hita, C; Díaz-López, A; Becerra-Tomás, N; Toledo, E; Cornejo-Pareja, I; Abete, I; Sureda, A; Bes-Rastrollo, M; Martínez, JA; Tinahones, FJ; Tur, (2023). Associations between ultra-processed food consumption and kidney function in an older adult population with metabolic syndrome. Findings from PREDIMED-Plus trial. Clinical Nutrition, 42(12), 2302-2310. DOI: 10.1016/j.clnu.2023.09.028

Article's DOI: 10.1016/j.clnu.2023.09.028

Entity: Universitat Rovira i Virgili

Journal publication year: 2023

Publication Type: Journal Publications