Articles producció científica> Ciències Mèdiques Bàsiques

Fish oil supplementation counteracts the effect of high-fat and high-sucrose diets on the carbonylated proteome in the rat cerebral cortex

  • Identification data

    Identifier: imarina:9331039
    Authors:
    Moreno, FMéndez, LRaner, AMiralles-Pérez, BRomeu, MRamos-Romero, STorres, JLMedina, I
    Abstract:
    High daily intake of saturated fats and refined carbohydrates, which often leads to obesity and overweight, has been associated with cognitive impairment, premature brain aging and the aggravation of neurodegenerative diseases. Although the molecular pathology of obesity-related brain damage is not fully understood, the increased levels of oxidative stress induced by the diet seem to be definitively involved. Being protein carbonylation determinant for protein activity and function and a main consequence of oxidative stress, this study aims to investigate the effect of the long-term high-fat and sucrose diet intake on carbonylated proteome of the cerebral cortex of Sprague-Dawley rats. To achieve this goal, the study identified and quantified the carbonylated proteins and lipid peroxidation products in the cortex, and correlated them with biometrical, biochemical and other redox status parameters. Results demonstrated that the obesogenic diet selectively increased oxidative damage of specific proteins that participate in fundamental pathways for brain function, i.e. energy production, glucose metabolism and neurotransmission. This study also evaluated the antioxidant properties of fish oil to counteract diet-induced brain oxidative damage. Fish oil supplementation demonstrated a stronger capacity to modulate carbonylated proteome in the brain cortex. Data indicated that fish oils did not just decrease carbonylation of proteins affected by the obesogenic diet, but also decreased the oxidative damage of other proteins participating in the same metabolic functions, reinforcing the beneficial effect of the supplement on those pathways. The results could help contribute to the development of successful nutritional-based interventions to prevent cognitive decline and promote
  • Others:

    Author, as appears in the article.: Moreno, F; Méndez, L; Raner, A; Miralles-Pérez, B; Romeu, M; Ramos-Romero, S; Torres, JL; Medina, I
    Department: Ciències Mèdiques Bàsiques
    URV's Author/s: Miralles Pérez, Bernat / Romeu Ferran, Marta
    Keywords: Protein carbonylation Prediabetes Oxidative stress Omega-3 fish oil High-fat and high-sucrose diet Cerebral cortex proteins protein carbonylation prediabetes polyphenols phospholipids parkinsons-disease oxidative stress model mice inflammation high-fat and high-sucrose diet docosahexaenoic acid cerebral cortex brain
    Abstract: High daily intake of saturated fats and refined carbohydrates, which often leads to obesity and overweight, has been associated with cognitive impairment, premature brain aging and the aggravation of neurodegenerative diseases. Although the molecular pathology of obesity-related brain damage is not fully understood, the increased levels of oxidative stress induced by the diet seem to be definitively involved. Being protein carbonylation determinant for protein activity and function and a main consequence of oxidative stress, this study aims to investigate the effect of the long-term high-fat and sucrose diet intake on carbonylated proteome of the cerebral cortex of Sprague-Dawley rats. To achieve this goal, the study identified and quantified the carbonylated proteins and lipid peroxidation products in the cortex, and correlated them with biometrical, biochemical and other redox status parameters. Results demonstrated that the obesogenic diet selectively increased oxidative damage of specific proteins that participate in fundamental pathways for brain function, i.e. energy production, glucose metabolism and neurotransmission. This study also evaluated the antioxidant properties of fish oil to counteract diet-induced brain oxidative damage. Fish oil supplementation demonstrated a stronger capacity to modulate carbonylated proteome in the brain cortex. Data indicated that fish oils did not just decrease carbonylation of proteins affected by the obesogenic diet, but also decreased the oxidative damage of other proteins participating in the same metabolic functions, reinforcing the beneficial effect of the supplement on those pathways. The results could help contribute to the development of successful nutritional-based interventions to prevent cognitive decline and promote brain health.
    Thematic Areas: Saúde coletiva Química Pharmacology & pharmacy Pharmacology Odontología Medicine, research & experimental Medicine (miscellaneous) Medicina veterinaria Medicina iii Medicina ii Medicina i Materiais Interdisciplinar Farmacia Engenharias iii Engenharias ii Enfermagem Educação física Ciências biológicas iii Ciências biológicas ii Ciências biológicas i Ciências agrárias i Ciência de alimentos Ciência da computação Biotecnología Biodiversidade Astronomia / física
    licence for use: https://creativecommons.org/licenses/by/3.0/es/
    Author's mail: bernat.miralles@urv.cat marta.romeu@urv.cat
    Author identifier: 0000-0003-1294-7069 0000-0002-2131-1858
    Record's date: 2024-08-03
    Papper version: info:eu-repo/semantics/publishedVersion
    Link to the original source: https://www.sciencedirect.com/science/article/pii/S0753332223015068?via%3Dihub
    Licence document URL: https://repositori.urv.cat/ca/proteccio-de-dades/
    Papper original source: Biomedicine & Pharmacotherapy. 168
    APA: Moreno, F; Méndez, L; Raner, A; Miralles-Pérez, B; Romeu, M; Ramos-Romero, S; Torres, JL; Medina, I (2023). Fish oil supplementation counteracts the effect of high-fat and high-sucrose diets on the carbonylated proteome in the rat cerebral cortex. Biomedicine & Pharmacotherapy, 168(), -. DOI: 10.1016/j.biopha.2023.115708
    Article's DOI: 10.1016/j.biopha.2023.115708
    Entity: Universitat Rovira i Virgili
    Journal publication year: 2023
    Publication Type: Journal Publications
  • Keywords:

    Medicine (Miscellaneous),Medicine, Research & Experimental,Pharmacology,Pharmacology & Pharmacy
    Protein carbonylation
    Prediabetes
    Oxidative stress
    Omega-3 fish oil
    High-fat and high-sucrose diet
    Cerebral cortex
    proteins
    protein carbonylation
    prediabetes
    polyphenols
    phospholipids
    parkinsons-disease
    oxidative stress
    model
    mice
    inflammation
    high-fat and high-sucrose diet
    docosahexaenoic acid
    cerebral cortex
    brain
    Saúde coletiva
    Química
    Pharmacology & pharmacy
    Pharmacology
    Odontología
    Medicine, research & experimental
    Medicine (miscellaneous)
    Medicina veterinaria
    Medicina iii
    Medicina ii
    Medicina i
    Materiais
    Interdisciplinar
    Farmacia
    Engenharias iii
    Engenharias ii
    Enfermagem
    Educação física
    Ciências biológicas iii
    Ciências biológicas ii
    Ciências biológicas i
    Ciências agrárias i
    Ciência de alimentos
    Ciência da computação
    Biotecnología
    Biodiversidade
    Astronomia / física
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