Author, as appears in the article.: Mateo, D; Marquès, M; Domingo, JL; Torrente, M
Department: Psicologia Ciències Mèdiques Bàsiques
URV's Author/s: Domingo Roig, José Luis / Marquès Bueno, Montserrat / Mateo García, David / Torrente Torné, Margarita
Keywords: Probiotics Parkinson disease dementia Gut microbiota Dementia Chain fatty-acids Alzheimer disease probiotics parkinsons-disease parkinson disease dementia gut microbiota dementia brain
Abstract: Dementia is one of today's greatest public health challenges. Its high socio-economic impact and difficulties in diagnosis and treatment are of increasing concern to an aging world population. In recent years, the study of the relationship between gut microbiota and different neurocognitive disorders has gained a considerable interest. Several studies have reported associations between gut microbiota dysbiosis and some types of dementia. Probiotics have been suggested to restore dysbiosis and to improve neurocognitive symptomatology in these dementias. Based on these previous findings, the available scientific evidence on the gut microbiota in humans affected by the most prevalent dementias, as well as the probiotic trials conducted in these patients in recent years, have been here reviewed. Decreased concentrations of short-chain fatty acids (SCFA) and other bacterial metabolites appear to play a major role in the onset of neurocognitive symptoms in Alzheimer disease (AD) and Parkinson disease dementia (PDD). Increased abundance of proinflammatory taxa could be closely related to the more severe clinical symptoms in both, as well as in Lewy Bodies dementia. Important lack of information was noted in Frontotemporal dementia behavioral variant. Moreover, geographical differences in the composition of the gut microbiota have been reported in AD. Some potential beneficial effects of probiotics in AD and PDD have been reported. However, due to the controversial results further investigations are clearly necessary.© 2023 The Authors. American Journal of Medical Genetics Part B: Neuropsychiatric Genetics published by Wiley Periodicals LLC.
Thematic Areas: Saúde coletiva Psychiatry and mental health Psychiatry Psicología Medicina ii Medicina i Genetics (clinical) Genetics & heredity General medicine Ensino Ciências biológicas ii Ciências biológicas i Cellular and molecular neuroscience Biotecnología Biodiversidade
licence for use: https://creativecommons.org/licenses/by/3.0/es/
Author's mail: david.mateo@urv.cat montserrat.marques@urv.cat margarita.torrente@urv.cat joseluis.domingo@urv.cat david.mateo@urv.cat
Author identifier: 0000-0001-6302-8578 0000-0002-8901-6345 0000-0001-6647-9470
Record's date: 2024-02-18
Papper version: info:eu-repo/semantics/publishedVersion
Link to the original source: https://onlinelibrary.wiley.com/doi/10.1002/ajmg.b.32959
Licence document URL: http://repositori.urv.cat/ca/proteccio-de-dades/
Papper original source: American Journal Of Medical Genetics Part B-Neuropsychiatric Genetics. 195 (2): e32959-e32959
APA: Mateo, D; Marquès, M; Domingo, JL; Torrente, M (2024). Influence of gut microbiota on the development of most prevalent neurodegenerative dementias and the potential effect of probiotics in elderly: A scoping review. American Journal Of Medical Genetics Part B-Neuropsychiatric Genetics, 195(2), e32959-e32959. DOI: 10.1002/ajmg.b.32959
Article's DOI: 10.1002/ajmg.b.32959
Entity: Universitat Rovira i Virgili
Journal publication year: 2024
Publication Type: Journal Publications
Repositori URV