Articles producció científica> Psicologia

Influence of gut microbiota on the development of most prevalent neurodegenerative dementias and the potential effect of probiotics in elderly: A scoping review

  • Identification data

    Identifier: imarina:9331073
  • Authors:

    Mateo, D
    Marquès, M
    Domingo, JL
    Torrente, M
    American Journal Of Medical Genetics Part B-Neuropsychiatric Genetics
    10.1002/ajmg.b.32959
    American Journal Of Medical Genetics Part B-Neuropsychiatric Genetics. 195 (2): e32959-e32959
  • Others:

    Author, as appears in the article.: Mateo, D; Marquès, M; Domingo, JL; Torrente, M
    Department: Psicologia Ciències Mèdiques Bàsiques
    URV's Author/s: Domingo Roig, José Luis / Marquès Bueno, Montserrat / Mateo García, David / Torrente Torné, Margarita
    Keywords: Probiotics Parkinson disease dementia Gut microbiota Dementia Chain fatty-acids Alzheimer disease probiotics parkinsons-disease parkinson disease dementia gut microbiota dementia brain
    Abstract: Dementia is one of today's greatest public health challenges. Its high socio-economic impact and difficulties in diagnosis and treatment are of increasing concern to an aging world population. In recent years, the study of the relationship between gut microbiota and different neurocognitive disorders has gained a considerable interest. Several studies have reported associations between gut microbiota dysbiosis and some types of dementia. Probiotics have been suggested to restore dysbiosis and to improve neurocognitive symptomatology in these dementias. Based on these previous findings, the available scientific evidence on the gut microbiota in humans affected by the most prevalent dementias, as well as the probiotic trials conducted in these patients in recent years, have been here reviewed. Decreased concentrations of short-chain fatty acids (SCFA) and other bacterial metabolites appear to play a major role in the onset of neurocognitive symptoms in Alzheimer disease (AD) and Parkinson disease dementia (PDD). Increased abundance of proinflammatory taxa could be closely related to the more severe clinical symptoms in both, as well as in Lewy Bodies dementia. Important lack of information was noted in Frontotemporal dementia behavioral variant. Moreover, geographical differences in the composition of the gut microbiota have been reported in AD. Some potential beneficial effects of probiotics in AD and PDD have been reported. However, due to the controversial results further investigations are clearly necessary.© 2023 The Authors. American Journal of Medical Genetics Part B: Neuropsychiatric Genetics published by Wiley Periodicals LLC.
    Thematic Areas: Saúde coletiva Psychiatry and mental health Psychiatry Psicología Medicina ii Medicina i Genetics (clinical) Genetics & heredity General medicine Ensino Ciências biológicas ii Ciências biológicas i Cellular and molecular neuroscience Biotecnología Biodiversidade
    licence for use: https://creativecommons.org/licenses/by/3.0/es/
    Author's mail: montserrat.marques@urv.cat david.mateo@urv.cat joseluis.domingo@urv.cat margarita.torrente@urv.cat
    Author identifier: 0000-0001-6302-8578 0000-0001-6647-9470 0000-0002-8901-6345
    Record's date: 2024-07-20
    Papper version: info:eu-repo/semantics/publishedVersion
    Link to the original source: https://onlinelibrary.wiley.com/doi/10.1002/ajmg.b.32959
    Licence document URL: http://repositori.urv.cat/ca/proteccio-de-dades/
    Papper original source: American Journal Of Medical Genetics Part B-Neuropsychiatric Genetics. 195 (2): e32959-e32959
    APA: Mateo, D; Marquès, M; Domingo, JL; Torrente, M (2024). Influence of gut microbiota on the development of most prevalent neurodegenerative dementias and the potential effect of probiotics in elderly: A scoping review. American Journal Of Medical Genetics Part B-Neuropsychiatric Genetics, 195(2), e32959-e32959. DOI: 10.1002/ajmg.b.32959
    Article's DOI: 10.1002/ajmg.b.32959
    Entity: Universitat Rovira i Virgili
    Journal publication year: 2024
    Publication Type: Journal Publications
  • Keywords:

    Cellular and Molecular Neuroscience,Genetics & Heredity,Genetics (Clinical),Psychiatry,Psychiatry and Mental Health
    Probiotics
    Parkinson disease dementia
    Gut microbiota
    Dementia
    Chain fatty-acids
    Alzheimer disease
    probiotics
    parkinsons-disease
    parkinson disease dementia
    gut microbiota
    dementia
    brain
    Saúde coletiva
    Psychiatry and mental health
    Psychiatry
    Psicología
    Medicina ii
    Medicina i
    Genetics (clinical)
    Genetics & heredity
    General medicine
    Ensino
    Ciências biológicas ii
    Ciências biológicas i
    Cellular and molecular neuroscience
    Biotecnología
    Biodiversidade
  • Documents:

  • Cerca a google

    Search to google scholar