Author, as appears in the article.: Donat-Vargas, C; Mico, V; San-Cristobal, R; Martínez-González, MA; Salas-Salvadó, J; Corella, D; Fitó, M; Alonso-Gómez, AM; Wärnberg, J; Vioque, J; Romaguera, D; López-Miranda, J; Estruch, R; Damas-Fuentes, M; Lapetra, J; Serra-Majem, L; Bueno-Cavanillas, A; Tur, JA; Cinza-Sanjurjo, S; Pintó, X; Delgado-Rodríguez, M; Matía-Martín, P; Vidal, J; Causso, C; Ros, E; Toledo, E; Manzanares, JM; Ortega-Azorín, C; Castañer, O; Peña-Orihuela, PJ; Zazo, JM; Muñoz Bravo, C; Martinez-Urbistondo, D; Chaplin, A; Casas, R; Cano Ibáñez, N; Tojal-Sierra, L; Gómez-Perez, AM; Pascual Roquet-Jalmar, E; Mestre, C; Barragán, R; Schröder, H; Garcia-Rios, A; Candela García, I; Ruiz-Canela, M; Babio, N; Malcampo, M; Daimiel, L; Martinez, A
Department: Medicina i Cirurgia Bioquímica i Biotecnologia
URV's Author/s: Babio Sánchez, Nancy Elvira / Manzanares Errazu, José María / Salas Salvadó, Jorge
Keywords: Quality of life Older adults Mini-mental state Iron Epidemiology Diabetes Cognition Anemia womens-health validity quality of life performance older adults mortality mediterranean diet iron impairment hemoglobin executive function epidemiology diabetes anemia alzheimers-disease
Abstract: Anemia causes hypo-oxygenation in the brain, which could lead to cognitive disorders. We examined dietary iron intake as well as anemia markers (i.e., hemoglobin, hematocrit, mean corpuscular volume) and diabetes coexistence in relation to neuropsychological function and quality of life. In this study, 6117 community-dwelling adults aged 55-75 years (men) and 60-75 years (women) with overweight/obesity and metabolic syndrome were involved. We performed the Mini-Mental State Examination (MMSE), the Trail Making Test parts A and B (TMT-A/B), Semantic Verbal Fluency of animals (VFT-a), Phonological Verbal Fluency of letter P (VFT-p), Digit Span Test (DST), the Clock Drawing Test (CDT), and the Short Form-36 Health Survey (SF36-HRQL test). Dietary iron intake did not influence neuropsychological function or quality of life. However, anemia and lower levels of anemia markers were associated with worse scores in all neurophysiological and SF36-HRQL tests overall, but were especially clear in the MMSE, TMT-B (cognitive flexibility), and the physical component of the SF36-HRQL test. The relationships between anemia and diminished performance in the TMT-A/B and VFT tasks were notably pronounced and statistically significant solely among participants with diabetes. In brief, anemia and reduced levels of anemia markers were linked to inferior cognitive function, worse scores in different domains of executive function, as well as a poorer physical, but not mental, component of quality of life. It was also suggested that the coexistence of diabetes in anemic patients may exacerbate this negative impact on cognition. Nevertheless, dietary iron intake showed no correlation with any of the outcomes. To make conclusive recommendations for clinical practice, our findings need to be thoroughly tested through methodologically rigorous studies that minimize the risk of reverse causality.
Thematic Areas: Zootecnia / recursos pesqueiros Saúde coletiva Química Psicología Planejamento urbano e regional / demografia Nutrition and dietetics Nutrition & dietetics Nutrição Medicina veterinaria Medicina iii Medicina ii Medicina i Interdisciplinar Food science Farmacia Engenharias iv Engenharias ii Enfermagem Educação física Economia Ciências biológicas iii Ciências biológicas ii Ciências biológicas i Ciências agrárias i Ciência de alimentos Biotecnología
licence for use: https://creativecommons.org/licenses/by/3.0/es/
Author's mail: josemaria.manzanares@urv.cat jordi.salas@urv.cat josemaria.manzanares@urv.cat nancy.babio@urv.cat
Author identifier: 0000-0003-2700-7459 0000-0003-3527-5277
Record's date: 2024-08-03
Papper version: info:eu-repo/semantics/publishedVersion
Link to the original source: https://www.mdpi.com/2072-6643/15/20/4440
Licence document URL: https://repositori.urv.cat/ca/proteccio-de-dades/
Papper original source: Nutrients. 15 (20):
APA: Donat-Vargas, C; Mico, V; San-Cristobal, R; Martínez-González, MA; Salas-Salvadó, J; Corella, D; Fitó, M; Alonso-Gómez, AM; Wärnberg, J; Vioque, J; Ro (2023). Dietary Iron, Anemia Markers, Cognition, and Quality of Life in Older Community-Dwelling Subjects at High Cardiovascular Risk. Nutrients, 15(20), -. DOI: 10.3390/nu15204440
Article's DOI: 10.3390/nu15204440
Entity: Universitat Rovira i Virgili
Journal publication year: 2023
Publication Type: Journal Publications
Repositori URV