Author, as appears in the article.: Sánchez-Resino, E; Marquès, M; Gutiérrez-Martín, D; Restrepo-Montes, E; Martínez, MA; Salas-Huetos, A; Babio, N; Salas-Salvadó, J; Gil-Solsona, R; Gago-Ferrero, P
Department: Bioquímica i Biotecnologia Ciències Mèdiques Bàsiques
URV's Author/s: Babio Sánchez, Nancy Elvira / Marquès Bueno, Montserrat / Martínez Rodríguez, María Ángeles / Salas Huetos, Albert / Salas Salvadó, Jorge / Sánchez Resino, Elena
Keywords: Seminal plasma Semen quality Organophosphate flame retardants Male fertility Led-fertyl study Human exposure High-resolution mass spectrometry Emerging pollutants urine seminal plasma semen quality phthalate metabolites male fertility liquid-chromatography led-fertyl study insect repellent human exposure environmental contaminants emerging pollutants chlorinated pesticides bisphenol-a
Abstract: Understanding the potential impact of organic contaminants on male fertility is crucial, yet limited studies have examined these chemicals in semen, with most focusing on urine and blood. To address this gap, we developed and validated a robust LC-HRMS methodology for semen analysis, with a focus on polar and semipolar chemicals. Our methodology enables the quantitative (or semiquantitative) analysis of >2000 chemicals being compatible with suspect and nontarget strategies and providing unprecedented insights into the occurrence and potential bioaccumulation of diverse contaminants in this matrix. We comprehensively analyzed exogenous organic chemicals and associated metabolites in ten semen samples from Spanish participants collected in an area with a large presence of the chemical industry included in the LED-FERTYL Spanish study cohort. This investigation revealed the presence of various contaminants in semen, including plastic additives, PFAS, flame retardants, surfactants, and insecticides. Notably, prevalent plastic additives such as phthalic acid esters and bisphenols were identified, indicating potential health risks. Additionally, we uncovered previously understudied chemicals like the tire additive 2-mercaptobenzothiazole and specific organophosphate flame retardants. This study showcases the potential of our methodology as a valuable tool for large-scale cohort studies, providing insights into the association between contaminant exposure and the risk of male fertility impairments.
Thematic Areas: Zootecnia / recursos pesqueiros Saúde coletiva Química Medicine (miscellaneous) Medicina ii Medicina i Materiais Interdisciplinar Geociências General medicine General chemistry Farmacia Environmental sciences Environmental chemistry Engineering, environmental Engenharias iv Engenharias iii Engenharias ii Engenharias i Economia Ciências biológicas iii Ciências biológicas ii Ciências biológicas i Ciências ambientais Ciências agrárias i Ciência de alimentos Chemistry (miscellaneous) Chemistry (all) Biotecnología Biodiversidade Astronomia / física
licence for use: https://creativecommons.org/licenses/by/3.0/es/
Author's mail: elena.sanchez@urv.cat albert.salas@urv.cat mangeles.martinez@urv.cat montserrat.marques@urv.cat nancy.babio@urv.cat jordi.salas@urv.cat elena.sanchez@urv.cat
Author identifier: 0000-0001-5914-6862 0000-0001-8595-3772 0000-0001-6302-8578 0000-0003-3527-5277 0000-0003-2700-7459
Record's date: 2024-01-13
Papper version: info:eu-repo/semantics/publishedVersion
Link to the original source: https://pubs.acs.org/doi/10.1021/acs.est.3c04347#
Licence document URL: http://repositori.urv.cat/ca/proteccio-de-dades/
Papper original source: Environmental Science & Technology. 57 (48): 19236-19252
APA: Sánchez-Resino, E; Marquès, M; Gutiérrez-Martín, D; Restrepo-Montes, E; Martínez, MA; Salas-Huetos, A; Babio, N; Salas-Salvadó, J; Gil-Solsona, R; Gag (2023). Exploring the Occurrence of Organic Contaminants in Human Semen through an Innovative LC-HRMS-Based Methodology Suitable for Target and Nontarget Analysis. Environmental Science & Technology, 57(48), 19236-19252. DOI: 10.1021/acs.est.3c04347
Article's DOI: 10.1021/acs.est.3c04347
Entity: Universitat Rovira i Virgili
Journal publication year: 2023
Publication Type: Journal Publications
Repositori URV