Articles producció científica> Ciències Mèdiques Bàsiques

Exploring the Occurrence of Organic Contaminants in Human Semen through an Innovative LC-HRMS-Based Methodology Suitable for Target and Nontarget Analysis

  • Identification data

    Identifier: imarina:9331788
    Authors:
    Sánchez-Resino, EMarquès, MGutiérrez-Martín, DRestrepo-Montes, EMartínez, MASalas-Huetos, ABabio, NSalas-Salvadó, JGil-Solsona, RGago-Ferrero, P
    Abstract:
    Understanding the potential impact of organic contaminants on male fertility is crucial, yet limited studies have examined these chemicals in semen, with most focusing on urine and blood. To address this gap, we developed and validated a robust LC-HRMS methodology for semen analysis, with a focus on polar and semipolar chemicals. Our methodology enables the quantitative (or semiquantitative) analysis of >2000 chemicals being compatible with suspect and nontarget strategies and providing unprecedented insights into the occurrence and potential bioaccumulation of diverse contaminants in this matrix. We comprehensively analyzed exogenous organic chemicals and associated metabolites in ten semen samples from Spanish participants collected in an area with a large presence of the chemical industry included in the LED-FERTYL Spanish study cohort. This investigation revealed the presence of various contaminants in semen, including plastic additives, PFAS, flame retardants, surfactants, and insecticides. Notably, prevalent plastic additives such as phthalic acid esters and bisphenols were identified, indicating potential health risks. Additionally, we uncovered previously understudied chemicals like the tire additive 2-mercaptobenzothiazole and specific organophosphate flame retardants. This study showcases the potential of our methodology as a valuable tool for large-scale cohort studies, providing insights into the association between contaminant exposure and the risk of male fertility impairments.
  • Others:

    Author, as appears in the article.: Sánchez-Resino, E; Marquès, M; Gutiérrez-Martín, D; Restrepo-Montes, E; Martínez, MA; Salas-Huetos, A; Babio, N; Salas-Salvadó, J; Gil-Solsona, R; Gago-Ferrero, P
    Department: Bioquímica i Biotecnologia Ciències Mèdiques Bàsiques
    URV's Author/s: Babio Sánchez, Nancy Elvira / Marquès Bueno, Montserrat / Martínez Rodríguez, María Ángeles / Salas Huetos, Albert / Salas Salvadó, Jorge / Sánchez Resino, Elena
    Keywords: Seminal plasma Semen quality Organophosphate flame retardants Male fertility Led-fertyl study Human exposure High-resolution mass spectrometry Emerging pollutants urine seminal plasma semen quality phthalate metabolites male fertility liquid-chromatography led-fertyl study insect repellent human exposure environmental contaminants emerging pollutants chlorinated pesticides bisphenol-a
    Abstract: Understanding the potential impact of organic contaminants on male fertility is crucial, yet limited studies have examined these chemicals in semen, with most focusing on urine and blood. To address this gap, we developed and validated a robust LC-HRMS methodology for semen analysis, with a focus on polar and semipolar chemicals. Our methodology enables the quantitative (or semiquantitative) analysis of >2000 chemicals being compatible with suspect and nontarget strategies and providing unprecedented insights into the occurrence and potential bioaccumulation of diverse contaminants in this matrix. We comprehensively analyzed exogenous organic chemicals and associated metabolites in ten semen samples from Spanish participants collected in an area with a large presence of the chemical industry included in the LED-FERTYL Spanish study cohort. This investigation revealed the presence of various contaminants in semen, including plastic additives, PFAS, flame retardants, surfactants, and insecticides. Notably, prevalent plastic additives such as phthalic acid esters and bisphenols were identified, indicating potential health risks. Additionally, we uncovered previously understudied chemicals like the tire additive 2-mercaptobenzothiazole and specific organophosphate flame retardants. This study showcases the potential of our methodology as a valuable tool for large-scale cohort studies, providing insights into the association between contaminant exposure and the risk of male fertility impairments.
    Thematic Areas: Zootecnia / recursos pesqueiros Saúde coletiva Química Medicine (miscellaneous) Medicina ii Medicina i Materiais Interdisciplinar Geociências General medicine General chemistry Farmacia Environmental sciences Environmental chemistry Engineering, environmental Engenharias iv Engenharias iii Engenharias ii Engenharias i Economia Ciências biológicas iii Ciências biológicas ii Ciências biológicas i Ciências ambientais Ciências agrárias i Ciência de alimentos Chemistry (miscellaneous) Chemistry (all) Biotecnología Biodiversidade Astronomia / física
    licence for use: https://creativecommons.org/licenses/by/3.0/es/
    Author's mail: montserrat.marques@urv.cat albert.salas@urv.cat mangeles.martinez@urv.cat elena.sanchez@urv.cat jordi.salas@urv.cat nancy.babio@urv.cat
    Author identifier: 0000-0001-6302-8578 0000-0001-5914-6862 0000-0001-8595-3772 0000-0003-2700-7459 0000-0003-3527-5277
    Record's date: 2024-08-03
    Papper version: info:eu-repo/semantics/publishedVersion
    Link to the original source: https://pubs.acs.org/doi/10.1021/acs.est.3c04347#
    Licence document URL: https://repositori.urv.cat/ca/proteccio-de-dades/
    Papper original source: Environmental Science & Technology. 57 (48): 19236-19252
    APA: Sánchez-Resino, E; Marquès, M; Gutiérrez-Martín, D; Restrepo-Montes, E; Martínez, MA; Salas-Huetos, A; Babio, N; Salas-Salvadó, J; Gil-Solsona, R; Gag (2023). Exploring the Occurrence of Organic Contaminants in Human Semen through an Innovative LC-HRMS-Based Methodology Suitable for Target and Nontarget Analysis. Environmental Science & Technology, 57(48), 19236-19252. DOI: 10.1021/acs.est.3c04347
    Article's DOI: 10.1021/acs.est.3c04347
    Entity: Universitat Rovira i Virgili
    Journal publication year: 2023
    Publication Type: Journal Publications
  • Keywords:

    Chemistry (Miscellaneous),Engineering, Environmental,Environmental Chemistry,Environmental Sciences,Medicine (Miscellaneous)
    Seminal plasma
    Semen quality
    Organophosphate flame retardants
    Male fertility
    Led-fertyl study
    Human exposure
    High-resolution mass spectrometry
    Emerging pollutants
    urine
    seminal plasma
    semen quality
    phthalate metabolites
    male fertility
    liquid-chromatography
    led-fertyl study
    insect repellent
    human exposure
    environmental contaminants
    emerging pollutants
    chlorinated pesticides
    bisphenol-a
    Zootecnia / recursos pesqueiros
    Saúde coletiva
    Química
    Medicine (miscellaneous)
    Medicina ii
    Medicina i
    Materiais
    Interdisciplinar
    Geociências
    General medicine
    General chemistry
    Farmacia
    Environmental sciences
    Environmental chemistry
    Engineering, environmental
    Engenharias iv
    Engenharias iii
    Engenharias ii
    Engenharias i
    Economia
    Ciências biológicas iii
    Ciências biológicas ii
    Ciências biológicas i
    Ciências ambientais
    Ciências agrárias i
    Ciência de alimentos
    Chemistry (miscellaneous)
    Chemistry (all)
    Biotecnología
    Biodiversidade
    Astronomia / física
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